183results about How to "Excellent anticoagulant properties" patented technology

The invention relates to a medical apparatus, in particular to an anticoagulant stainless steel coronary support which is made from a high-nitrogen nickel-free austenitic stainless steel material with good blood compatibility. The support is of tubular structure with a mesh surface which is formed by orderly arranging a unit figure on the side surface of a tube along the circumference and axial direction, the primary supporting function is provided by U-shaped corrugated mesh wires extending along the axial direction, the corrugated mesh wires are connected into a whole body by soft mesh wires arranged at intervals, and the diameter of the mesh wire (width or thickness) is 40-100mum; and the surface of the support is passivated and coated with a medication. The anticoagulant stainless steel support has the advantages of good mechanical properties, good flexibility and good anticoagulant property, and can be used as a support for cardiovascular and cerebrovascular systems or a support for other cavity bodies.

A method of biolization to the surface of inorganic material includes the following steps: the surface is spattered to form a tantalum oxide or a titanium oxide thin film; and then the inorganic material is put in a plasma immersion ion implantation device; after vacuumization, hydrogen, water vapour or ammonia is fed in, with gas pressure 0.05 to 50 Pa; the radio frequency discharge power is 200 to 1200W; the range value of the loaded pulse high-voltage power is 1KV to 100KV, the frequency is 50 to 40000HZ, and the duty ratio is 3 percent to 80 percent; the heating temperature is 20 to 500 DEG C; the treatment time is 0.1 to 5 hours; finally, the inorganic material is put into 10 to 100mg / mL albumin or heparin solution to be soaked for 2 to 48 hours under 20 to 40 DEG C soaking temperature. The method does not damage the activity of the biomolecule and the protein; the prepared inorganic material with biolized surface has good anti-coagulability, is used for medical blood vessel scaffolds and artificial heart valves, and can greatly improve the product performance.

The invention discloses an anticoagulation high polymer biomaterial which comprises a substrate layer, an anticoagulation coating, and a plasma polymerization layer positioned between the substrate layer and the anticoagulation coating, wherein the substrate layer is made of a biomedical material; the plasma polymerization layer is an allylamine plasma polymerization membrane layer deposited on the substrate layer; the anticoagulation coating is an anticoagulant layer fixed on the plasma polymerization layer; and the anticoagulants comprise hirudin, heparin and the like. Anticoagulant molecules are fixedly grafted on the material surface by utilizing the pulsed plasma technology and surface heparin grafting method, and effective molecule orientation is remained by heparin molecules, so the anticoagulant performance is close to the performance of heparin molecules in the solution. Meanwhile, the heparin molecules are difficultly scoured off by blood, the persistence and stability of the anticoagulation effect are guaranteed, and the service life is long. The invention further discloses a preparation method and application of the anticoagulation high polymer biomaterial.

The invention relates to a fatty group polyester-polyamino acid copolymer with biology function and its synthesis method in the field of macromole biological medicine material technique. The block copolymer comprises: the two block copolymer (A) of fatty group polyester -polyamino acid with biology function and three block copolymer (B), and polyoxyethylene-fatty group polyester-polyamino acid three block copolymer (C). The synthesis method comprises: synthesizing the block copolymer of the carboxylic which is protected by benzyl, doing catalytic reduction to the palladium wood coal or hydrolyzing hydrogen bromide to generate the corresponding polymer with free carboxyl, then using NHS (N- hydroxyl succinimide-sauba) to active the flank carboxyl of the polyamino acid section, reacting it with short peptide, sugar or drug with RGD to obtain the fatty group polyester-polyamino acid copolymer with biology function.

The invention discloses a preparation method of an anticoagulant material with function of inducing and catalyzing release of endogenous NO. The method comprises the steps of: configuring an alkaline Tris-buffer buffer solution, and adding a compound with certain concentration and pyrogallol structure and a compound with disulfide bond or diselenium bond and containing amino or thiol at two ends; and placing the substrate materials in a reaction solution, controlling the reaction temperature, reacting for 1-24 h, removing the substrate, and cleaning and drying to obtain the objective material. The invention has the advantages of simple operation, mild reaction conditions and easy operation. The component unit of the compound with disulfide bond or diselenium bond and containing amino or thiol at two ends has controllable content; the modified coating prepared by the method has excellent adhesion, and catalyzes the blood NO donors to continuously release NO molecules through in situ catalysis, inhibits activation and aggregation of platelets, inhibits proliferation of smooth muscle cells, and protects vascular endothelium.

The invention relates to a preparation process of repairing materials for tissues and organs, in particular to a preparation process of repairing material for tissues and complex organs. It makes PHBHHx as main materials to prepare film type, single tube, multiple tubes and net tube materials. It uses PLLA, PLGA, PCL, PU, other degradable high molecular materials, drug, growth factor, cell and other components to prepare a material for repairing tissues and organs with favorable anticoagulant property, biological compatibility, comparative highly machinery intensity and toughness, and matching degradation rate with the growth rate of the complex organs.

The invention discloses a citric acid and chitosan modified biocompatible polyurethane and a preparation method thereof. A main chain of the polyurethane disclosed by the invention is a polyurethane long chain, the two ends of the long chain are respectively an anticoagulative citric acid structure covalently grafted with the long chain, and a chitosan structure is selectively grafted on the citric acid structure. The preparation method comprises the following steps: firstly, adding isocyanate, polyethylene glycol and a catalyst into a reactor, and carrying out stirring reaction for 2-5 h in the presence of nitrogen; then, adding a citric acid, and heating for reacting for 12-18 h, so that a citric acid modified polyurethane is obtained; and activating the citric acid modified polyurethane by using carbodiimide, and soaking the obtained object into a chitosan-acetic acid solution to carry out acid-amide condensation reaction, so that the modified biocompatible polyurethane is obtained. According to the citric acid and chitosan modified biocompatible polyurethane disclosed by the invention, the citric acid structures with biocompatibility and the chitosan structure are covalently bonded in the polyurethane long chain, so that the polyurethane has good chemical stability and biocompatibility, and can be used as a biomedical material; and the preparation method has the advantages of simple and easily-controlled process, low cost, and the like.

The invention provides a long-acting antibacterial multifunctional coating based on bionic dopamine as well as a preparation method and an application thereof. The preparation method comprises the following steps: carrying out ultrasonic cleaning on a base material by using acetone, absolute ethyl alcohol and ultrapure water in sequence; immersing the obtained base material into dopamine rapid deposition liquid for reaction to obtain a base material coated with a polydopamine coating; washing the obtained base material with deionized water, and drying; soaking the obtained base material in a multifunctional coating aqueous solution for reaction, and obtaining a functional coating on the surface of the base material; washing the obtained base material with ultrapure water and then drying; wherein Cu<2+> and H2O2 are dissolved in the dopamine rapid deposition liquid, and the multifunctional coating aqueous solution contains a hydrophilic polymer or a zwitterionic polymer. The preparation process is simple, conditions are mild, deposition preparation time is greatly shortened, and the method is suitable for large-scale industrial production.

The invention provides an anticoagulant fiber membrane and a preparation method and application thereof. The anticoagulant fiber membrane comprises a polyvinylidene fluoride membrane and a metal organic framework material with a carboxyl group, and the metal organic framework material with the carboxyl group is uniformly dispersed in the polyvinylidene fluoride membrane. The metal organic framework material in the anticoagulant fiber membrane can stably exist in a polyvinylidene fluoride membrane matrix. In addition, the anticoagulant fiber membrane has a good anticoagulant effect, and the result of the embodiment shows that the prothrombin time of the activated part of the anticoagulant fiber membrane is 42-60 seconds, and the anticoagulant effect is better. The anticoagulant fiber membrane has better hydrophilic properties, and the result of the embodiment shows that the contact angle between the anticoagulant fiber membrane and water is 50-80 degrees.

The invention discloses a composite vascular stent which comprises stent bodies and composite drug coatings, wherein the stent bodies are wrapped with the composite drug coatings, and are bare metal stents, degradable polymer stents, degradable magnesium alloy stents or degradable iron alloy stents; the bare metal stents are 316 L stainless-steel stents; each composite drug coating is a composite coating which comprises a dopamine polymer layer, 1-10 layers of anticoagulative drug and 1-10 layers of endothelial regeneration promoting cell factors in sequence from inside to outside; the anticoagulative drug is heparin; the composite drug coatings are wrapped with protein A layers and antibody drug layers; each antibody drug layer comprises antibodies CD34. The composite vascular stent has the benefits as follows: the drug coatings provided by the invention are uniform, resistant to washing and stable, have a high capability of capturing endothelial progenitor cells, can achieve the purposes of well inhibiting thrombosis and reducing restenosis and have an important clinical application value.

The invention discloses a preparation method of a hyperbranched polyimide anti-coagulant antibacterial material, and belongs to the field of chemical materials. The surface of amino-terminated hyperbranched polyimide is subjected to graft modification by 2-methacryloyloxyethyl phosphorylcholine to form a hyperbranched polyimide film, and the biocompatibility, anticoagulant property and antibacterial property of the prepared HBPI-MPC film are good.

The present invention relates to a super biphobic block polyether type polyurethane copolymer, its end group is fluorocarbon hydrophobic group and its middle is hydrophilic chain segment, and its general formula is [CF3(CF2)n(CH2)mO]x-Pu-[O(CH2)m(CF2)nCF3]x. Its preparation process includes the following steps: pre-heating hydrophilic polyether diol and one-ended hydroxy fluoroalcohol, placing them into reactor under the condition of argon gas protection, cooling and adding diisocyanate and adding long-chain chain-extending agent, stirring to make reaction. Said copolymer has good anti-coagulating property, can be used for preparing bio-medical material, and can be used for protecting surface of ship body and building.

The invention relates to the field of tissue engineering, in particular to a preparation method of a composite nanometer fiber small-diameter intravascular tissue engineering stent material. The technical scheme is achieved as follows: formic acid is used as a common solvent; RGD-recombinant spider silk protein, polycaprolactone and chitosan are mixed in a mass ratio of 1:8:1 according to the requirements of an intravascular stent to prepare a spinning solution with the concentration of 20-30 percent (w / v); electrospinning process parameters are as follows: the diameter of a cross section of acylindrical rotating shaft is 3-6 mm, the rotating speed is 1,500-3,000rpm, the curing distance is 15-30 cm, the voltage is 50-150kV, the extrusion speed is 3-7ml / h and the temperature is 45-50 DEG C. The small-diameter intravascular stent has favorable cell adhesion-promoting capability, anticoagulant property and mechanical property for resisting physiological environment and can be clinicallyapplied as a small-diameter intravascular tissue engineering stent.

The invention discloses a shape memory type high-elasticity activity nano-fiber stent and application thereof. The shape memory type high-elasticity activity nano-fiber stent is manufactured by introducing biological activity components (laminin, heparin, CD34+, VEGF and the like) into degradable linear elasticity polyester PCT with a shape memory effect through an electrostatic spinning technology; the molecular weight of the linear elasticity polyester PCT is 50000-400000, and the percentage composition of functionality caprolactone monomers, containing side cyclic ether substitutes, in a copolyester is 5-50%. The shape memory type high-elasticity activity nano-fiber stent is a high-activity nano-fiber stent with human body biomechanics elasticity, is a three-dimensional degradable tissue engineering stent which can provide an ideal biomechanics environment and an ideal biological activity microenvironment for cell growth, and is expected to be widely applied to regeneration and repair of elastic human body tissue such as blood vessels, cardiac muscles, nerves, skin, tendon, heart and the like.

The invention relates to a method for constructing a hemocompatible material surface with a bionic periodic structure. The method comprises the following steps of: deducing a theoretical prediction formula of surface appearance contact angle of the periodic micro-structure surface according to a micro-pillar surface model, and determining whether the designed micro-structure surface has ideal super-hydrophobicity according to the formula; etching to form a micro-pillar hard template with array structure according to the periodic micro-structure, casting PDMS (polydimethylsiloxane) on the hard template, allowing cross-linking and curing of the PDMS, and stripping off the cured film as an elastic template; and casting a prepolymer on the elastic template, and curing to form a micro-pattern on the polymer surface, which is complementary to the elastic template but similar to the original template. The bionic hemocompatible material constructed by the invention can effectively inhibit adhesion and deformation of platelets, prevent activation of coagulation pathway and increase duration of anticoagulation. Besides, the wetting property of the interface is improved by reasonable regulation of surface geometric dimension, so that the hemocompatibility of the material is improved.

The invention discloses an anticoagulation coating material and a preparation method thereof. The anticoagulation coating material comprises sodium hyaluronate and hirudin, wherein the sodium hyaluronate is formed into a gel network; the hirudin is in covalent binding with the sodium hyaluronate. The preparation method of the anticoagulation coating material comprises the following steps: (1) preparing an MES (Fatty Acid Methyl Ester Sulfonate) buffer solution; (2) preparing a sodium hyaluronate solution with the concentration of 1mg / ml to 20mg / ml; (3) preparing a hirudin solution with the concentration of 1mg / ml to 10mg / ml; (4) uniformly mixing up the two solutions so as to enable the mass ratio of the hirudin to the sodium hyaluronate to be 1:1 to 1:10; (5) adding a crosslinking agent into the mixture solution obtained in the step (4), uniformly mixing up so as to covalently crosslink the hirudin and the sodium hyaluronate. The anticoagulation coating material disclosed by the invention is high in anticoagulation activity, stable in effect, long in lasting time, good in biocompatibility, simple in preparation method, gentle in condition and applicable to large-scale industrial production.

The invention discloses a method for preparing an anticoagulant composite coating. The method for preparing the anticoagulant composite coating comprises the steps of first using a coupling agent to process the surface of a pre-processed biomedical base material to obtain a hydrophilic surface, using a specific anticoagulant composite coating to modify the biomedical base material, and obtaining a biomedical material having good anticoagulation property after drying. Studies have shown that the biomedical material modified by the anticoagulant composite coating is greatly improved in hydrophilicity and shows excellent biocompatibility. The modified material can not only maintain its original physical and mechanical properties, but also greatly extend activated partial thromboplastin time (APTT) in the coagulation test to show excellent anticoagulant properties.

The invention discloses a carrageenan-based self-anticoagulant heparitin microsphere, as well as a preparation method and application thereof. The carrageenan-based self-anticoagulant heparitin microsphere comprises a carrageenan microsphere of a network structure and a polyacrylic acid crosslinked network constructed by a crosslinking agent and interspersed with a carrageenan microsphere network.The microsphere is low in cytotoxicity and high in biocompatibility and anticoagulant property and has a structure and functional group similar to anticoagulant heparitin. The interspersed carrageenan network and polyacrylate crosslinked network form double networks and the double networks are restricted by each other, so that the mechanical strength of the microsphere is strengthened, the swelling rate is limited, breakage of the microsphere in a using process can be effectively avoided, the dimensional stability of the microsphere can be maintained in use and the microsphere is a novel adsorption material with application prospect for a hemoditoxifier.

The invention discloses a preparation method of a hyperbranched polyimide anticoagulant and antibacterial material, which belongs to the field of chemical materials. The present invention uses 2-methacryloyloxyethyl phosphorylcholine to graft and modify the surface of amino-terminated hyperbranched polyimide to form a hyperbranched polyimide film, and the prepared HBPI-MPC film biophase Capacitive, anticoagulant and antibacterial properties are better.

The invention discloses a modified polymer film as well as a preparation method and application thereof, and particularly relates to the field of modified polymer films. The preparation method comprises the following steps: dropwise adding a sulfanilic acid diazonium salt solution into Na<+> intercalated MXene, and after reaction, centrifuging, filtering, washing, ultrasonically treating and freeze-drying to obtain sulfonated MXene powder; immersing a polymer film in a GA / polyethyleneimine (PEI) mixed solution containing trihydroxymethyl aminomethane and metal salt, and reacting to obtain a GAcoating modified polymer film; and depositing the sulfonated MXene powder on the GA coating modified polymer film, and repeating the operations to obtain the single-layer or multi-layer GA / MXene modified polymer film. According to the invention, two methods, namely vacuum assisted suction filtration and layer-by-layer self-assembling, are combined, and the method has the characteristics of uniform film coating, controllable film thickness, better stability, low energy consumption and easiness in operation. In addition, the prepared modified polymer film has the functions of efficiently removing medium and small molecular toxins and having good oxidation resistance and protein adsorption resistance.

The present invention relates to a block hydrophobic and oleophobic polyether type polyurethane copolymer, its preparation method and application in preparation of biological medicinal material. The end group of the described copolymer is fluorocarbon group, and the described copolymer has the following general formula: PU-[O(CH2)m(CF2)nCF3]x, in which PU represents polyether type polyurethane, n value is 3-20, m value is 0-12, x=2-6. Said preparation method includes copolymerization reaction of diisocyanate and polyether glycol and chain extender in the presence of one-ended hydroxyfluoroalcohol, in which the mole ratio of diisocyanate: polyether glycol: chain extender is 1.0:0.2-0.5:0.5-1.0, and the one-ended hydroxyfluoroalcohol content is 1-20% of weight percentage content of the reaction system, and polymerization temp. is 50-120 deg.C.

The invention provides a multifunctional stent coating based on recombinant human collagen and a preparation method of the multifunctional stent coating. The preparation method comprises the followingsteps: (1) activating a substrate material; (2) placing the activated substrate material into a solution containing an amino compound to react to obtain an aminated substrate material; (3) placing the aminated substrate material into a poly-negative electrolyte solution to react and then washing the aminated substrate material with de-ionized water; (4) placing the product obtained in step (3) into a poly-positive electrolyte solution to react and then washing the product with de-ionized water; and (5) taking the product obtained in step (2) as a substrate at room temperature and repeating the step (3) to the step (4) for 3-15 times to prepare the multifunctional stent coating. The multifunctional stent coating prepared by the invention can be used for effectively improving anticoagulation and rapid endothelialization properties of biological materials including vascular stent materials and the like, and the problems of late thrombus and restenosis of a current stent material are potentially reduced.

The invention relates to a preparation method of developing polyurethane, which pertains to the technical field of high polymer material. The preparation method comprises the steps that: firstly, polymers, diatomic alcohol and diisocyanate are mixed; the mixture of the diatomic alcohol and the diisocyanate is stirred and reacts under the protection of nitrogen gas to obtain a prepolymer; after the temperature thereof is raised, the prepolymer is added with a chain extender and stirred for reaction; and the polymers are cured. As the chain extender contains developing atoms and developing groups are connected with the polyurethane by the effect of chemical bonds, the developing polyurethane prepared by the preparation method has long lasting development effect, good stability, biocompatibility and anticoagulant performance, arouses no inflammation in human bodies, is biological aging resistant and animalcule resistant, has good physical properties, can be sterilized by usual methods, is easy to be processed and takes advantages over non-developing polyurethane when being applied to heart valves, conduits and vascular stents. The preparation method is flexible, effective, simple and easy to be realized.

The invention provides a coating method for an activated carbon adsorbent for blood perfusion. Firstly, coating film is formed on the surface of activated carbon with chitosan, then crosslinking is executed with epichlorohydrin to increase the strength of the film, and finally heparin sodium having an anticoagulant effect is grafted to the surface of the film. The crosslinked chitosan film can improve the blood compatibility of the activated carbon and decrease particle falling of the activated carbon; the heparin sodium having an excellent anticoagulant property is grafted on the film so thatthe blood coagulation phenomenon occurring when blood is in contact with the surface of the activated carbon can be decreased, and the safety of a perfusion device is improved.

The invention relates to artificial organs that has taken surface modification process. The surface of artificial organs is coated titanium dioxide composite membrane that has been doped by light rare earth element lanthanum and / or cerium. The thickness of titanium dioxide composite membrane is 20-600nm, and the 60-300nm is optical selection. The mol content of lanthanum and / or cerium is 0.1-20%, and optical selection is 0.2-10%. The composite membrane could be deposited onto surface of base body of artificial organs by magnetron sputtering technology. The blood compatibility, and wear resistance would be entirely improved.

The invention discloses an organosilicon separating gel, its preparation method and application. The silicone separating gel is made of the following components in parts by weight: 54-82 parts of organopolysiloxane; 4-15 parts of hydroxyl silicone oil; 10- 25 parts; 1-6 parts of silane coupling agent. The preparation method of the organosilicon separating gel is to mix the components uniformly, heat up to 60-116°C, stir and keep warm for 5-12 hours, and then vacuumize at 120-180°C for 1-6 hours to obtain the organosilicon separating gel. glue. The application of the organosilicon separating gel is to prepare a rapid blood collection tube with serum separating gel. The organosilicon separating gel provided by the invention is hygienic, safe, non-toxic, strong in isolation, good in liquid sealing, and has superior thixotropic performance. The invention provides a method for preparing organic silicon separating gel, which has simple process, mild and controllable preparation conditions, and is easy to popularize.

A blood vessel scaffold is prepared from a mixture of polyurethane (PU) and polyhydroxy aliphatic ester (PHA), and is composed of multi-porous tunica intima, solid adventitia and reinforcing ribs. Its advantages are high biocompatibility, anticoagulation and cell adhesion, proper degradation speed, and improved mechanical strength and stitch strength.

The invention refers to a manmade materials for medicial anticoagulant and the manufacturing method. It solves the problem that anticoagulant problem of blood osculant materials. It is used to produce osculant blood pipe, medicinal appliance and manmade blood vessel. It comprises polyamine ester and metallic oxide nano materials. The method is that the polyamine ester is resolve in N,N-dimethylacetamide or N,N-dimethylformamide and forms the polyamine ester liquid, the metallic oxide nano materials are put into the liquid. Through high-speed mixing, shocking, and moulding, then the solvent is eliminated. The invention has good anticoagulant effect, high stretching intensity and rupture tensibility. The method and craft and the device is simple and the cost is low.

The invention discloses an anticoagulation medical device, and a preparation method thereof. The preparation method comprises following steps: a, a device main body of the anticoagulation medical device is prepared; and b, the surface of the device main body is coated with a positively charged polyelectrolyte and a negatively charged polyelectrolyte via alternate adsorption so as to form a coating layer and obtain the anticoagulation medical device. The preparation method also comprises a step of crosslinking of the positively charged polyelectrolyte with the negatively charged polyelectrolyte using a cross-linking agent. The preparation method is simple; preparation can be realized using a simple solution circulating device; a stable coating structure can be obtained via crosslinking; preparation can be carried out at mild aqueous environment; no toxic solvent is used; the preparation method is friendly to the environment; no special requirement on the shape structure of the anticoagulation medical device is required by the preparation method; and preparation can be realized on the surfaces of a plurality of medical devices with complex structures.

The invention relates to a nanofiber-based composite hemodialysis membrane and a preparation method thereof. The preparation method includes the steps that a high-molecular polymer solution is subjected to electrostatic spinning, a nanofiber non-woven fabricis obtained, and subjected to cold pressing, and then a nanofiber porous supporting layer is obtained; after silk is subjected to degumming, dissolving, dialyzing, vulcanizing and self-assembling, a vulcanized silk fibroin protein nanowire precursor is obtained; a prepared vulcanized silk fibroin protein nanowire and polyvinyl alcohol are added into water; and then glutaric dialdehyde is added to be crosslinked, the mixture is coated in the nanofiber porous supporting layer, and the nanofiber-based composite hemodialysis membrane can beobtained after sealing at the room temperature. According to the preparation method of the nanofiber-based composite hemodialysis membrane, silk materials with the characteristics of low cost and wide sources are used for preparing the vulcanized silk fibroin protein nanowire, the process is simple, and implementation is easy; and the obtained nanofiber-based composite hemodialysis membrane has good water permeability, the excellent dialysis efficiency and anticoagulant activity.