34results about How to "Good biological compatibility" patented technology

Embodiments of the present invention provide an osseointegrative implant and related tools, components and fabrication techniques for surgical bone fixation and dental restoration purposes. In one embodiment an all-ceramic single-stage threaded or press-fit implant is provided having finely detailed surface features formed by ceramic injection molding and/or spark plasma sintering of a powder compact or green body comprising finely powdered zirconia. In another embodiment a two-stage threaded implant is provided having an exterior shell or body formed substantially entirely of ceramic and/or CNT-reinforced ceramic composite material. The implant may include one or more frictionally anisotropic bone-engaging surfaces. In another embodiment a densely sintered ceramic implant is provided wherein, prior to sintering, the porous debound green body is exposed to ions and/or particles of silver, gold, titanium, zirconia, YSZ, α-tricalcium phosphate, hydroxyapatite, carbon, carbon nanotubes, and/or other particles which remain lodged in the implant surface after sintering. Optionally, at least the supragingival portions of an all-ceramic implant are configured to have high translucence in the visible light range. Optionally, at least the bone-engaging portions of an all-ceramic implant are coated with a fused layer of titanium oxide.

Disclosed are multi-functional markers for use on various products, particularly products which have one or more visually indistinguishable characteristics, for identifying and/or providing information about such products, and to processes and materials for making and using such markers.

The invention relates to a method for mediating proteins to synthesize and modify a cerium nano material. The method is characterized in that serum protein with certain concentration is mixed with cerous nitrate to prepare a precursor solution of the cerium nano material; the precursor solution has nucleation growth under a potassium hydroxide solution alkaline condition; a reaction temperature and reaction time are further controlled, so that a cerium nano cluster, cerium nano particles and a cerium nano chain material are obtained in a controlled manner, and the cerium nano cluster, the cerium nano particles and the cerium nano chain material have good uniformity, dispersion and stability. Corresponding characterization analysis is carried out on the nano material and the surface thereof, so that BSA or HAS for correspondingly modifying the surface of the cerium nano material has excellent biological compatibility, has a great number of modifying functional groups such as carboxyl and an amino group, and further can graft and modify other functional molecules, and therefore, a foundation is laid for further applying the method in a living body. According to the method, reaction is green and economical, a control way is flexible and easily controlled, and repeatability is strong.

The invention provides a preparation method of a composite carbon nano tube reinforced hydroxyapatite material and relates to a composition using phosphate as a basic material. A chemical vapor deposition method is used for preparing carbon nano tubes, functionalization treatment is conducted on the carbon nano tubes, a method integrating a magnetic liquid-phase stirring method and a hydrogel method is adopted to conduct in-site collagen layer coating on the surfaces of the carbon nano tubes subjected to the functionalization treatment, and thus the collagen coated composite carbon nano tube reinforced hydroxyapatite material is prepared through a dry-state press-forming method. The method overcomes the defects that the composite carbon nano tube reinforced hydroxyapatite material ubiquitous in the prior art is low in interface bonding strength and poor in carbon nano tube dispersity and accordingly the comprehensive mechanical property of the composite material is low; the composite material is poor in biocompatibility, or even has toxicity, and certain risk exists when the material serves as a biomedical material; the effect of repairing migration, growth and differentiation of bone cells is poor; the material is poor in usage effect when serving as the biomedical material.

The invention discloses a preparation method of an internal haemostatic dressing. The preparation method is characterized by taking human-like collagen as a raw material, adding injection water, stirring and dissolving, then freezing by setting a specific cooling rate for accurately cooling and pre-freezing, vacuum freezing and drying, then carrying out thermal crosslinking, irradiating Co60 and sterilizing to finally obtain an internal haemostatic dressing. The internal haemostatic dressing prepared by the method is high in safety, high in biocompatibility and obvious in haemostatic effect, can be applied to hemostasis of various wounds and post-operation hemostasis, and has good application prospects in relevant fields of biomedical materials and tissue engineering.

The invention relates to an antibacterial polyurethane foam material and a preparation method and application thereof, solves the technical problems of high cost and non-ideal effect of the existing nasal cavity hemostatic material, and provides the antibacterial polyurethane foam material. The antibacterial effective component in the antibacterial polyurethane foam material is long side chain quaternized chitosan with 12 carbons on the side chain. The invention also provides a preparation method and application thereof. The material can be used in the field of antibacterial materials.

The invention relates to a method for synthesizing modified cerium nanometer quantum dots under mediation of hyaluronic acid and a product and application thereof. The method comprises the following specific steps: dissolving hyaluronic acid by adding water, then adding trivalent cerium salt, reacting for 0.5-1h under a magnetic stirring condition to synthesize a precursor, then adding an alkalinesolution into a reaction system, performing a nucleating and curing reaction, and purifying to remove unreacted inorganic ions and the unreacted hyaluronic acid to obtain the hyaluronic acid-coated cerium nanometer quantum dots. By the method, the reaction is environmentally friendly and economical, the regulative way is flexible and easy to control, and the repeatability is strong; the obtainedquantum dots are uniform in shape and size and good in dispersibility and stability; the HA for modifying the surfaces of the cerium nanometer quantum dots has excellent biocompatibility and a large amount of carboxyl functional groups for modifying, so that the HA can further modify other functional molecules in a grafting manner, and a foundation is laid for further in-vivo application of the cerium nanometer quantum dots.

The invention relates to a preparation method for a novel separation medium. The preparation method comprises the following steps: adding a certain quantity of inorganic salt and multiple crosslinking agent beta-diimine zinc compound and 1,2,7,8-diepoxyoctane into macromolecular protein solution; regulating the pH (Potential of Hydrogen) of the solution to be 2-5.5; after even mixing, carrying out water bath heating to prepare saliferous hydrogel; carrying out 110-121 DEG C high-temperature treatment and distilled water dipping and washing on the prepared saliferous hydrogel to remove inorganic salt and monomer crosslinking agent residues; drying to obtain high-intensity porous hydrogel. The hydrogel has the advantages of good elasticity, high resistance to compression and good selective separation ability and is expected to serve as a novel separation medium in a separation purification field, the maximum compressive strain and the maximum compression stress respectively can be 70% and 5-6MPa, and porosity is controllable in 75-90%.