34results about How to "Good biological compatibility" patented technology

The invention discloses a dental partially-glass-infiltrated functionally-gradient zirconia ceramic material. The dental partially-glass-infiltrated functionally-gradient zirconia ceramic material is composed of three layers, i.e., (1) a glass layer with a thickness of 0.2 mm, (2) a glass-infiltrated zirconia functionally-gradient layer with a thickness of 0.3 mm and (3) a compact zirconia layer with a thickness of 0.5 mm, wherein glass comprises, by mass, 15% of La2O3, 5% of ZrO2, 5% of Y2O3, 20% of SiO2, 15% of B2O3, 15% of BaO, 15% of Al2O3, 4% of TiO2, 4% of CaO, 1% of CeO2 and 1% of Fe2O3. The bonding strength between the dental partially-glass-infiltrated functionally-gradient zirconia ceramic material and veneering porcelain is increased by 2.5 times compared with the bonding strength of a traditional zirconia material. The dental partially-glass-infiltrated functionally-gradient zirconia ceramic material has good biocompatibility and accords with standards prescribed in ISO-7405 and ISO-7406 Technical Reports--Biological Assessment of Dental Materials.

Disclosed are multi-functional markers for use on various products, particularly products which have one or more visually indistinguishable characteristics, for identifying and / or providing information about such products, and to processes and materials for making and using such markers.

The invention relates to a method for protein-mediated synthesis and modification of cerium nanomaterials. Firstly, a certain concentration of serum protein and cerium nitrate are mixed to form a precursor solution of cerium nanomaterials, which are nucleated and grown under alkaline conditions of potassium hydroxide solution. By further adjusting the reaction temperature and time, on the one hand, cerium nanoclusters, cerium nanoparticles and cerium nanochain materials are controllably obtained, and all have good uniformity, dispersion and stability. The nanomaterials and their surfaces were characterized and analyzed. On the other hand, the BSA or HSA modified on the surface of the corresponding cerium nanomaterials has excellent biocompatibility, and has a large number of functional groups available for modification, such as carboxyl, amino etc., and other functional molecules can be further grafted and modified, laying the foundation for its further application in vivo. The invention reflects green economy, flexible and easy-to-control regulation mode, and strong repeatability.

The invention relates to a preparation method for modified hydroxyapatite with grafted amino acid on the surface. The method comprises the following steps: firstly, preparing a mixed solution of ethyl alcohol and water, adjusting the pH value, then adding KH560, stirring and shaking the solution, then adding nanoscale hydroxyapatite, reacting for 0.5-1.5 h and obtaining modified hydroxyapatite; secondly, drying and grinding the modified hydroxyapatite, placing the modified hydroxyapatite in a buffered solution with the pH value controlled to be within 6-8 and amino acid of 3.0-20 mg / mL, shaking the solution for 20-30 h at 35-65 DEG C and grating amino acid to obtain the modified hydroxyapatite with grafted amino acid on the surface. According to the invention, the preparing method is simple, and the obtained modified hydroxyapatite with grafted amino acid on the surface has excellent biological compatibility, adsorbs a considerable amount of protein and enzyme, and is wide in application prospects.

This patent discloses a method for preparing a hemostatic dressing in the body. The preparation method uses human-like collagen as raw material, adds water for injection, stirs and dissolves, then freezes by setting a specific cooling rate to achieve precise cooling and pre-freezing, and vacuum freeze-drying. , and then after thermal cross-linking, Co60 irradiation sterilization, and finally an in-vivo hemostatic dressing was obtained. Preparation method of the present invention The in-vivo hemostatic dressing prepared by the present invention has high safety, good biocompatibility, and significant hemostatic effect. It can be used to stop bleeding on various wounds and after surgery, and has good application in related fields such as medical biomaterials and tissue engineering. application prospects.

The invention discloses a method capable of removing limescale and heavy metal ions in water and relates to the water treatment technology. The method capable of removing the limescale and the heavy metal ions in the water includes the steps of ultrasonically dispersing purified carbon nanotubes in anhydrous ethanol, mixing the dispersion liquid with dispersion liquid of oxidized graphene in the anhydrous ethanol, and subjecting the mixed liquid to ultrasonic treatment prior to suction filtration and vacuum drying so as to obtain oxidized graphene / carbon nanotube composite materials. The composite materials belonging to nanomaterials have excellent properties and comprise multiple kinds of active groups such as hydroxyl and carboxyl on the surfaces. The method capable of removing the limescale and the heavy metal ions in the water has the advantages that the method can remove pollutants through adsorptive effect of the surface groups and the heavy metal ions in sewage and is synergistic with the composite materials under the action of an applied magnetic field to remove the limescale; the method with secondary-pollution-free and adsorptive functions is simple in technological process and reliable in property so as to be applicable to such fields as targeted drug preparation, environment protection and pollutant monitoring; the method is simple in material preparation and low in cost and can be produced massively.

The invention relates to a preparation method of a novel separation medium. First, a certain amount of inorganic salt and composite crosslinking agent β-diimine zinc complex and 1,2,7,8-diepoxide are added to a macromolecular protein solution octane, adjust the pH of the solution to 2-5.5, stir well and then heat in a water bath to prepare a hydrogel. The prepared hydrogel is subjected to high temperature treatment at 110-121° C., soaked and washed in distilled water to remove the residual inorganic salt and monomer crosslinking agent, and then dried to obtain a high-strength porous hydrogel. The hydrogel has good elasticity and strong compression resistance, the maximum compressive strain and compressive stress can reach 70% and 5‑6MPa, respectively, the porosity can be controlled at 75‑90%, and it has good selective separation ability. Separation media are used in the field of separation and purification.

The invention relates to a method for preparing strontium-doped hydroxyapatite through supersound. The method comprises the following steps of (1) preparing Sr(NO3)2 solution, Ca(NO3)2 solution and (NH4)2HPO4 solution, and adjusting the pH value of the solutions to be between 10 and 11; (2) mixing the Sr(NO3)2 solution and the Ca(NO3)2 solution, adding PEG-4000 into the mixture, and stirring the mixture until the materials are dissolved to obtain mixed solution; (3) at the water-bath temperature of 20 to 60 DEG C, dropwise adding the (NH4)2HPO4 solution into the mixed solution, performing ultrasonic stirring reaction for 0.5 to 4 hours, standing and ageing a reaction product, washing the reaction product, and drying the reaction product under vacuum to obtain the strontium-doped hydroxyapatite. The strontium-doped hydroxyapatite can be used for absorbing heavy metal ions and target proteins, adding inorganic particles of a functional filtration film, water treatment and blood purification. The method is simple in process, convenient to operate and mild in condition. The prepared product is fine in particle and uniform in distribution and has excellent biological compatibility.

The invention discloses a layer-by-layer self-assembled drug carrier of polyornithine / carboxymethyl lentinan and a preparation method thereof, comprising an MSNs nano core and a layer-by-layer self-assembly of polyornithine and carboxymethyl lentinan in sequence. To form a shell, the MSNs cores were prepared by a sol-gel method. The present invention adopts the combined layer-by-layer self-assembly technology to wrap two polyelectrolytes with potential health-improving properties on the surface of MSNs, which can not only control the burst release effect produced by MSNs, but also obtain a better biological compatibility. release formulation.

The invention discloses a method for preparing medical spherical Co-Cr-Mo alloy particles. The method comprises the steps as follows: (1), a cylindrical metal electrode is prepared by alloy components in percentage by weight as follows: 27%-32% of Cr, 5%-7% of Mo, 0%-0.5% of Ni, 0%-0.2% of Fe, 0.26%-0.31% of C, 0.4%-0.65% of Si, 0%-0.5% of Mn, smaller than or equal to 0.1% of N, smaller than or equal to 0.2% of W, smaller than or equal to 0.005% of S, smaller than or equal to 0.01% of P, smaller than or equal to 0.1% of Ti, smaller than or equal to 0.01% of B, smaller than or equal to 0.1% of Al and the balance of Co; (2), the prepared metal electrode is horizontally mounted on an electrode swivel feeding mechanism of plasma rotating electrode powder preparation equipment; and (3), a plasma gun is started to generate electric arc, the electrode swivel feeding mechanism is started to enable the metal electrode to perform high-speed rotating feeding, end parts of the metal electrode are gradually molten by the high temperature generated by the electric arc, and a molten metal liquid is thrown away under the action of centrifugal force to form the spherical particles. The spherical Co-Cr-Mo alloy particles prepared with the method have good biological compatibility, a spherical particle coating is sintered on the prosthesis surface to form good biological mosaic, and the prosthesis is prevented from loosening and subsidence.

The invention relates to an amino-modified and thiol-group-modified magnetic carbon nanotube composite material and a preparation method thereof and aims to overcome the defects of poor dispersity, low introduction efficiency of functional groups and low degree of functionalization of carbon nanotubes. The composite material adopts a tubular structure, ferroferric oxide particles with the diameters being 10-20nm are uniformly deposited on the surfaces of the carbon nanotubes, and the outer surfaces of the ferroferric oxide nano-particles and the carbon nanotubes are coated with a layer of 5-10nm of film containing amino and thiol groups. The method comprises the following steps: dispersing the carbon nanotubes into a solution containing ferrous and ferric iron ions, adding ammonia water, and thus obtaining a ferroferric oxide / carbon nanotube composite material with superparamagnetism; after magnetic separation, dispersing into a mixed solution containing acetic acid, acetone and trimethoxysilylpropanethiol; after reaction, centrifugally separating and drying, and then dispersing into an ethanol solution; adding hydrazine under the protection of nitrogen; after reaction, respectively washing with water and ethanol; after vacuum drying, obtaining the amino-modified and thiol-group-modified magnetic carbon nanotube composite material.

The invention relates to a method for synthesizing modified cerium nanometer quantum dots under mediation of hyaluronic acid and a product and application thereof. The method comprises the following specific steps: dissolving hyaluronic acid by adding water, then adding trivalent cerium salt, reacting for 0.5-1h under a magnetic stirring condition to synthesize a precursor, then adding an alkalinesolution into a reaction system, performing a nucleating and curing reaction, and purifying to remove unreacted inorganic ions and the unreacted hyaluronic acid to obtain the hyaluronic acid-coated cerium nanometer quantum dots. By the method, the reaction is environmentally friendly and economical, the regulative way is flexible and easy to control, and the repeatability is strong; the obtainedquantum dots are uniform in shape and size and good in dispersibility and stability; the HA for modifying the surfaces of the cerium nanometer quantum dots has excellent biocompatibility and a large amount of carboxyl functional groups for modifying, so that the HA can further modify other functional molecules in a grafting manner, and a foundation is laid for further in-vivo application of the cerium nanometer quantum dots.