Method for synthesizing modified cerium nanometer quantum dots under mediation of hyaluronic acid and product and application thereof
A technology of nano-quantum dots and hyaluronic acid, which is applied in the field of nano-materials, can solve the problems that have not been seen based on hyaluronic acid-mediated synthesis and modification of cerium nano-quantum dots, and achieve a major role in promoting, application prospects, and stability And biocompatibility guarantee, repeatable effect
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Embodiment 1
[0031] Embodiment 1, the preparation of cerium nano quantum dots (HA molecular weight: 17kd; Cerium salt: Ce(NO 3 ) 3 .6H 2 O)
[0032] Take 50mg HA (molecular weight 17kd) and add it into 8.7mL distilled aqueous solution, take 500μL 0.1mol / L Ce(NO 3 ) 3 ·6H2 O was added to it, and under 600r / min magnetic stirring, after reacting at room temperature (25°C) for 30 minutes, 800 μL of 1mol / L NaOH was added to the above system, and the reaction was stopped after continuing the magnetic stirring reaction for 6 hours. Distilled water was dialyzed into a dialysis bag with a molecular weight cut off of 10,000 for 24 hours, and the water was changed every 6 hours, and the water change volume was 3 L / time. To remove unreacted cerium salt, hydroxide (OH - ) and other inorganic ions. Finally, it was placed in a 100kd (15mL) sleeve centrifuge tube and washed by centrifugation at 4500r / min for 4 times to remove excess unreacted HA to obtain cerium nano-quantum dots (HA@CQDs-1, 5mL, wi...
Embodiment 2
[0033] Embodiment 2, the preparation of cerium nano quantum dots (HA molecular weight: 5kd; Cerium salt: Ce(NO 3 ) 3 .6H 2 O)
[0034] Take 50mg HA (molecular weight 5kd) and add it into 8.5mL distilled aqueous solution, take 500μL 0.1mol / L Ce(NO 3 ) 3 ·6H 2 Add O to it, under 600r / min magnetic stirring, react at room temperature (25°C) for 15 minutes, take 1000 μL of 1mol / L NaOH and add it to the above system, continue the magnetic stirring reaction for 24 hours, stop the reaction, and place the above reaction solution in the Distilled water into a dialysis bag with a molecular weight cut off of 10,000 for dialysis for 24 hours, wherein the water was changed every 6 hours, and the water change volume was 3 L / time. To remove unreacted cerium salt, hydroxide (OH - ) and other inorganic ions. Finally, it was placed in a 100kd (15mL) sleeve centrifuge tube and washed by centrifugation at 4500r / min for 4 times to remove excess unreacted HA to obtain cerium nano-quantum dots...
Embodiment 3
[0035] Embodiment 3, the preparation of cerium nano quantum dots (HA molecular weight: 45kd; Cerium salt: Ce(NO 3 ) 3 .6H 2 O)
[0036] Take 50mg HA (molecular weight 45kd) and add it into 8.5mL distilled aqueous solution, take 500μL 0.1mol / L Ce(NO 3 ) 3 ·6H 2 Add O to it, under 1000r / min magnetic stirring, react at room temperature (25°C) for 1h, take 1000μL of 1mol / L NaOH and add it to the above system, continue the magnetic stirring reaction for 24h, stop the reaction, and place the above reaction solution in the Distilled water was dialyzed into a dialysis bag with a molecular weight cut off of 10,000 for 24 hours, and the water was changed every 6 hours, and the water change volume was 3 L / time. To remove unreacted cerium salt, hydroxide (OH - ) and other inorganic ions. Finally, it was placed in a 100kd (15mL) sleeve centrifuge tube and washed by centrifugation at 4500r / min for 4 times to remove excess unreacted HA to obtain cerium nano-quantum dots with an averag...
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