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Method for preparing polyimide (PI)/surface graft amino acid modified hydroxyapatite (HAP) hybrid membrane

A technology of hydroxyapatite and surface grafting, which is applied in the field of preparing polyimide/surface-grafted amino acid modified hydroxyapatite hybrid membranes to achieve excellent biological compatibility, prevent particle agglomeration, and adsorb A large amount of effect

Inactive Publication Date: 2015-07-15
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the synthesis of nano-hydroxyapatite composite materials has been reported in some literatures and patents. For example, Li et al. used alternate deposition methods to generate chitosan / gelatin / hydroxyapatite composite films. The concentration of the liquid to adjust the size of the generated hydroxyapatite (Junjie Li, YiPing Chen, Yuji Yin et al.Modulation of nano-hydroxyapatite size via formation on chitosan-gelatin network film in situ[J].Biomaterials,2007,28 :781-790); Wang Ning and others selected privet wood as the base material, roughened the surface through pretreatment, grafted polyethylene glycol, and then further treated the system through hydrothermal treatment to control the reaction time, temperature and pH value, the Fabrication of wood / hydroxyapatite composite as bone substitution material has been successfully prepared, however, there is no literature report on the preparation of PI / surface-grafted amino acid-modified HAP by in situ polymerization Hybrid Membrane Approach

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] At room temperature, add 10 g of 4,4'-diaminodiphenyl ether (ODA) and 60 ml of dimethylformamide into a round-bottomed flask, stir until completely dissolved, and then add homobenzene Tetraformic dianhydride (PMDA), stirred under a nitrogen atmosphere until completely dissolved, and then continued to stir for 10 hours to obtain a bright yellow and transparent polyamic acid (PAA) solution. The mass ratio to PAA is about 1:10) was added to 40ml of dimethylformamide, ultrasonically dispersed at room temperature for 30min, then added to the PAA solution, mechanically stirred and dispersed for 12h to obtain a PAA / modified HAP composite solution. After the PAA / modified HAP composite solution was left to defoam for 8 hours, it was coated on a smooth glass with a scraper, and the nascent film was pre-evaporated at 25°C for 60 minutes, and then immersed in dimethylformamide-water (mass ratio 9: 1) A uniform PAA / modified HAP hybrid film was obtained in the mixed coagulation bath....

Embodiment 2

[0030] At room temperature, add 10 g of 4,4'-diaminodiphenyl ether (ODA) and 60 ml of dimethylformamide into a round-bottomed flask, stir until completely dissolved, and then add homobenzene Tetraformic dianhydride (PMDA), stirred under nitrogen atmosphere until fully dissolved, then continued to stir the reaction for 10h, to obtain a bright yellow transparent polyamic acid (PAA) solution, simultaneously with the modified HAP (HAP and HAP) of 5g surface grafted serine The mass ratio of PAA is about 1:4) was added to 50ml of dimethylformamide, ultrasonically dispersed at room temperature for 40min, then added to the PAA solution, mechanically stirred and dispersed for 16h to obtain a PAA / modified HAP composite solution. After the PAA / modified HAP composite solution was left standing for degassing for 10 hours, it was coated on a smooth glass with a scraper, and the nascent film was pre-evaporated at 35°C for 50 minutes, and then immersed in dimethylformamide-water (mass ratio 4:...

Embodiment 3

[0032]At room temperature, add 10 g of 4,4'-diaminodiphenyl ether (ODA) and 60 ml of dimethyl sulfoxide into a round-bottomed flask, stir until completely dissolved, and then add homobenzene Tetraformic dianhydride (PMDA), stirred to dissolve completely under nitrogen atmosphere, then continue stirring reaction 10h, obtain bright yellow transparent polyamic acid (PAA) solution, simultaneously the modified HAP ( The mass ratio of HAP to PAA is about 1:2) was added to 60ml of dimethyl sulfoxide, ultrasonically dispersed at room temperature for 50min, then added to the PAA solution, mechanically stirred and dispersed for 20h to obtain a PAA / modified HAP composite solution. After the PAA / modified HAP composite solution was left to defoam for 12 hours, it was coated on a smooth glass with a scraper, and the nascent film was pre-evaporated at 45°C for 30 minutes, and then immersed in dimethylacetamide-water (mass ratio 7: 3) A uniform PAA / modified HAP hybrid film was obtained in the...

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Abstract

The invention relates to a method for preparing a polyimide (PI) / surface graft amino acid modified hydroxyapatite (HAP) hybrid membrane, which comprises the following steps: mixing 4,4'-diaminodiphenyl ether and a polar solvent, dissolving by stirring, adding pyromellitic dianhydride, dissolving by stirring in a nitrogen atmosphere, and reacting to obtain a polyamic acid (PAA) solution; adding surface graft amino acid modified HAP into a polar solvent, carrying out ultrasonic treatment, and adding into the PAA solution to obtain the PAA / modified HAP composite solution; standing for degassing, coating on glass, preevaporating, and immersing into a pure water coagulating bath or organic solvent-water mixed coagulating bath to obtain a PAA / modified HAP hybrid membrane; and carrying out imidization on the hybrid membrane to obtain the PI / modified HAP hybrid membrane. The method is simple. The obtained PI / modified HAP hybrid membrane has the advantages of excellent biocompatibility, high adsorption capacity for proteins and enzymes, favorable mechanical properties, favorable chemical corrosion resistance and wide application prospects.

Description

technical field [0001] The invention belongs to the field of hybrid film preparation, in particular to a method for preparing a polyimide / surface grafted amino acid modified hydroxyapatite hybrid film. Background technique [0002] Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HAP) are widely used in organic / inorganic hybrid materials because they are similar to the inorganic components in human bone tissue. However, HAP is an inorganic material, and when it is hybridized with an organic material, the interfacial compatibility of the two materials will decrease, thereby reducing the mechanical properties of the composite material. The most commonly used method to overcome this difficulty is to modify the surface of HAP. On the one hand, it can enhance the mechanical properties of hybrid materials, and on the other hand, it can make HAP uniformly dispersed in the matrix, which is conducive to the adsorption of hybrid materials to proteins and cells. Polyimide (PI) film has sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G73/10C08K9/04C08J5/18
Inventor 孙俊芬庞浩吕姿颖高蕊谦玲王小村
Owner DONGHUA UNIV
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