Polymeric hydrogel for dressing and preparation method of polymeric hydrogel

Abstract

The invention provides a polymeric hydrogel for dressing and a preparation method of the polymeric hydrogel, belonging to the fields of radiation chemical and biomedical polymeric materials. The polymeric hydrogel is prepared from gelatin, sodium carboxymethylcellulose, gulcomannan, water-soluble chitosan, polyglutamic acid, hyaluronic acid and the like which are good in biocompatibility through blending, hot orientation and packaging; by controlling the temperature of hot orientation as well as orientation force and orientation time, the mechanical strength of the hydrogel is enhanced, and through high energy ray irradiation crosslinking, a regular aggregation structure obtained from the orientation is further immobilized and enhanced so as to synthesize high-strength dressing. The hydrogel disclosed by the invention is good in physicochemical and biological properties, high in tensile strength and good in transparency, and the hydrogel is relatively good in antibacterial and healing-promoting effects when applied to dressing. The polymeric hydrogel for dressing disclosed by the invention not requires an adhesive, a non-woven fabric or other reinforcing layers during preparing, and the polymeric hydrogel is simple in process and low in energy consumption; and the polymeric hydrogel can achieve sterilization and disinfection when radiating, and the polymeric hydrogel can reduce production cost and bring about benefit for production in a large scale.

Description

technical field [0001] The invention relates to a polymer hydrogel for dressing and a preparation method thereof, belonging to the fields of radiation chemistry and biomedical polymer materials. Background technique [0002] Hydrogel is based on the three-dimensional cross-linked network structure of hydrophilic polymers, which can absorb a large amount of water and keep it in a swollen state without dissolving. It integrates the properties of water absorption, water retention, and slow release. Functional materials, especially suitable for the development of wet medical dressings. The hydrogel dressing is not only soft, transparent, water-permeable and oxygen-permeable, but also can accelerate wound healing while absorbing wound exudate, keeping the wound moist and debridement. Since Winter invented "wet therapy" in 1962 and found that wounds heal faster in a closed and humid environment, various wet dressings have been developed, but the characteristics of hydrogel dressi...

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Problems solved by technology

Although the composite layer enhances the mechanical strength of the hydrogel to a certain extent, the non-woven fabric used in it is opaque, which is not conducive to observing the wound healing, and the medical adhesive used to enhance the bonding between the composite layers makes the preparation process easier. for complex

CN1121876C discloses "hydrogel composite wound dressing and its radiation synthesis method". Water absorption is only 200-400%

CN101337086A discloses "a hydrogel dressing and its preparation method", which is composed of two layers of hydrogel, and the upper and lower layers are respectively prepared by radiation method and freeze-thaw radiation method, which has excellent transparency and liquid absorption performance, but Its freezing and thawing strength only reaches 11kPa after 6 times, and the preparation process is complicated, making it difficult to scale production

CN103480034A announced "irradiation cross-linked chitosan / gelatin / polyvinyl alcohol hydrogel dressing and its preparation method and application", the natural macromolecules adopted are chitosan and gelatin, and the synthetic macromolecules are polyvinyl alcohol. The hydrogel dressing prepared by radiation cross-linking has the advantages of anti-inflammatory, healing-promoting and good biocompatibility, but the liquid absorption ability is not strong, and polyvinyl alcohol is difficult to biodegrade, causing serious environmental problems

CN1320931C and CN101664562A also have the same problem, and CN1320931C also has toxic and harmful residues such as humectants and plasticizers

CN100389145C discloses "hydrogel containing natural polymers and its radiation preparation method", which uses a variety of natural polymers or their derivatives to mix with synthetic polymers, inorganic fillers, cross-linking sensitizers, etc., and prepares hydrogels through radiation cross-linking. Gels, composite non-woven fabrics or breathable films can be used in wound dressings, but residual raw materials, by-products and degradation products will affect their biocompatibility

CN103520767A announced "an antibacterial and healing-promoting hydrogel dressing and its preparation method", the main components are water-soluble polymers, pseudoplastic functional polymers, antibacterial agents and water, and curing radiation sterilization has obtained transparent and pure , a hydrogel dressing with good biocompatibility and significant antibacterial efficacy, but its liquid absorption capacity is limited and its flexibility is not obvious

As described in CN101244286A, the hydrogel dressing prepared by the freezing-thawing cycle method after irradiation, because it is a solution before irradiation, cannot be molded at one time, and the freezing-thawing cycle after irradiation still needs to be processed under aseptic conditions, and consumes It takes a long time, which is not conducive to the improvement of production efficiency

CN103044694A announced "a preparation method of bacterial cellulose / polyvinyl alcohol composite hydrogel", which uses first dipping to make polyvinyl alcohol immerse in the bacterial cellulose hydrogel, then undergoes defoaming and dehydration treatment, and irradiates to obtain a composite gel. Hydrogel, the process requires repeated high-temperature washing and rinsing, which is time-consuming and laborious

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