Preparation method of composite carbon nano tube reinforced hydroxyapatite material

A technology of hydroxyapatite and carbon nanotubes, applied in the field of phosphate-based compositions, can solve the problems of low interfacial bonding strength, toxicity, and risks, and achieve good reinforcement and toughening, and excellent mechanical properties. , to avoid the effect of agglomeration

Inactive Publication Date: 2017-09-08
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The method overcomes the low interfacial bonding strength of carbon nanotube-reinforced hydroxyapatite composite materials in the prior art, and the poor dispersion of carbon nanotubes, which leads to low comprehensive mechanical properties of the composite material; poor biocompatibility of the composite material, and even exists Toxicity, there are risks when used as a biomedical material; the repair effect on bone cell migration, growth and differentiation is poor; and the defect that the use as a biomedical material is not good

Method used

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  • Preparation method of composite carbon nano tube reinforced hydroxyapatite material
  • Preparation method of composite carbon nano tube reinforced hydroxyapatite material
  • Preparation method of composite carbon nano tube reinforced hydroxyapatite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The first step is to prepare carbon nanotube-hydroxyapatite composite powder:

[0035]Weigh the required mass of ferric chloride hexahydrate and hydroxyapatite particles with a particle size of 10nm at a mass ratio of 0.55:1, and mix the weighed The hydroxyapatite particles were added to deionized water to form a hydroxyapatite suspension with a molar concentration of 0.01mol / L, and then the weighed ferric chloride hexahydrate was added to the above-mentioned hydroxyapatite suspension, and stirred 2h, ferric chloride is uniformly impregnated in hydroxyapatite to obtain suspension I, suspension I: 25% (mass percentage) ammonia water=100:1 in volume ratio, add 25% (mass percentage) to above suspension I percentage) of ammonia water, and continue to stir for 1 hour to obtain suspension II, place the formed suspension II in an ultrasonic disperser, and disperse ultrasonically at a frequency of 20 kHz for 40 min to fully react ferric chloride and ammonia water to form Fe(OH)...

Embodiment 2

[0048] The first step is to prepare carbon nanotube-hydroxyapatite composite powder:

[0049] Weigh the required mass of ferric chloride hexahydrate and hydroxyapatite particles with a particle size of 40nm in a mass ratio of 1.2:1, and mix the weighed ferric chloride hexahydrate with a mechanical stirrer at a speed of 250r / min. The hydroxyapatite particles were added to deionized water to form a hydroxyapatite suspension with a molar concentration of 0.15mol / L, and then the weighed ferric chloride hexahydrate was added to the above-mentioned hydroxyapatite suspension, and stirred 3h, ferric chloride is uniformly impregnated in the hydroxyapatite to obtain the suspension I, the suspension I: 25% (mass percentage) ammonia water=60:1 in the volume ratio, add 25% (mass percentage) to the above suspension I percentage) of ammonia water, and continue to stir for 2.5 hours to obtain suspension II. Place the formed suspension II in an ultrasonic disperser, and ultrasonically disperse...

Embodiment 3

[0057] The first step is to prepare carbon nanotube-hydroxyapatite composite powder:

[0058] Weigh the required mass of ferric chloride hexahydrate and hydroxyapatite particles with a particle size of 60nm according to the ratio of 1.75:1 in mass ratio, and under the condition of stirring at a speed of 400r / min with a mechanical stirrer, the weighed The hydroxyapatite particles were added to deionized water to form a hydroxyapatite suspension with a molar concentration of 0.3mol / L, and then the weighed ferric chloride hexahydrate was added to the above-mentioned hydroxyapatite suspension, and stirred 4h, ferric chloride is uniformly impregnated in hydroxyapatite to obtain suspension I, suspension I: 25% (mass percentage) ammonia water=20:1 in volume ratio, add 25% (mass percentage) to above-mentioned suspension I percentage) of ammonia water, and continue to stir for 4 hours to obtain suspension II, place the formed suspension II in an ultrasonic disperser, and disperse it by...

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Abstract

The invention provides a preparation method of a composite carbon nano tube reinforced hydroxyapatite material and relates to a composition using phosphate as a basic material. A chemical vapor deposition method is used for preparing carbon nano tubes, functionalization treatment is conducted on the carbon nano tubes, a method integrating a magnetic liquid-phase stirring method and a hydrogel method is adopted to conduct in-site collagen layer coating on the surfaces of the carbon nano tubes subjected to the functionalization treatment, and thus the collagen coated composite carbon nano tube reinforced hydroxyapatite material is prepared through a dry-state press-forming method. The method overcomes the defects that the composite carbon nano tube reinforced hydroxyapatite material ubiquitous in the prior art is low in interface bonding strength and poor in carbon nano tube dispersity and accordingly the comprehensive mechanical property of the composite material is low; the composite material is poor in biocompatibility, or even has toxicity, and certain risk exists when the material serves as a biomedical material; the effect of repairing migration, growth and differentiation of bone cells is poor; the material is poor in usage effect when serving as the biomedical material.

Description

technical field [0001] The technical scheme of the invention relates to a composition with phosphate as the base material, specifically a method for preparing a carbon nanotube-reinforced hydroxyapatite composite material. Background technique [0002] Hydroxyapatite accounts for about 70% of the inorganic components of human hard tissues, and its structure is very similar to human bone tissue. In view of its non-toxic and non-carcinogenic effects, it has excellent biological activity, biodegradability, osteoconductivity, The characteristics of biocompatibility and non-immunogenicity are widely used in the field of biomedicine, especially as carriers of drugs and genes and bone tissue repair materials. However, the mechanical properties and reliability of pure hydroxyapatite are poor, and it cannot be directly used as a load-bearing bone to be implanted in the human body, which restricts its wide application in the biomedical field. Therefore, in order to meet the biologica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/50
CPCA61L27/425A61L27/50A61L2430/02C08L89/00
Inventor 李海鹏孙熙雯李袁军范佳薇孙连城杨爽刘斐然曹航畅刘雯
Owner HEBEI UNIV OF TECH
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