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Method for preparing strontium-doped hydroxyapatite through supersound

A strontium hydroxyapatite and ultrasonic technology, which is applied in the field of preparation of hydroxyapatite materials, can solve the problems of irregular powder morphology, poor powder crystallinity, product agglomeration, etc., and achieve inhibition of coalescence and growth. , The effect of reducing specific surface energy and large adsorption capacity

Inactive Publication Date: 2014-12-10
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Regarding the research on the synthesis of nano-HAP-Sr, the powder prepared by the chemical precipitation method has irregular morphology and poor uniformity; the powder obtained by the sol-gel method has poor crystallinity, and generally requires further sintering to obtain the desired crystal; the hydrothermal method High temperature and high pressure are required, and the product agglomeration is serious
In order to achieve the synthesis of strontium-doped hydroxyapatite with strong protein adsorption capacity, there are few reports on the preparation method of ultrasonic method.

Method used

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  • Method for preparing strontium-doped hydroxyapatite through supersound

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Experimental program
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Effect test

Embodiment 1

[0028] 250ml of Sr(NO 3 ) 2 , Ca(NO 3 ) 2 solution and 0.3mol / L (NH 4 ) 2 HPO 4 solution, and adjust the Sr, Ca, P solution with concentrated ammonia water to make the pH 10~11. Then use a graduated cylinder to accurately measure 24ml of Sr solution and 56ml of Ca solution and mix thoroughly, add 0.8g PEG-4000 (6% mass fraction), then add it to a three-necked flask, and turn on magnetic stirring to dissolve it vigorously. Under the ultrasonic water bath, the ultrasonic power is set to 100W, the working frequency is 53KHz, and the temperature of the water bath is controlled at 60°C. Use a constant pressure dropping funnel to put 80ml of (NH 4 ) 2 HPO 4 The solution was slowly added dropwise into the mixture of Sr and Ca, and reacted for 30 min under ultrasonic stirring. After the reaction, the product was aged at room temperature for 12 hours, then washed with absolute ethanol several times and filtered with suction to obtain a white paste, which was put into a vacuum...

Embodiment 2

[0030] 250ml of Sr(NO 3 ) 2 , Ca(NO 3 ) 2 solution and 0.3mol / L (NH 4 ) 2 HPO 4 solution, and adjust the Sr, Ca, P solution with concentrated ammonia water to make the pH 10~11. Then use a graduated cylinder to accurately measure 40ml of Sr solution and 40ml of Ca solution and mix thoroughly, add 0.8g PEG-4000 (6% mass fraction), then add it into a three-necked flask, and turn on magnetic stirring to dissolve it vigorously. Under the ultrasonic water bath, the ultrasonic power is set to 100W, the working frequency is 53KHz, and the temperature of the water bath is controlled at 60°C. Use a constant pressure dropping funnel to put 80ml of (NH 4 ) 2 HPO 4 The solution was slowly added dropwise into the mixture of Sr and Ca, and reacted for 1 h under ultrasonic stirring. After the reaction, the product was aged at room temperature for 12 hours, then washed with absolute ethanol several times and filtered with suction to obtain a white paste, which was put into a vacuum ...

Embodiment 3

[0032] 250ml of Sr(NO 3 ) 2 , Ca(NO 3 ) 2 solution and 0.3mol / L (NH 4 ) 2 HPO 4 solution, and adjust the Sr, Ca, P solution with concentrated ammonia water to make the pH 10~11. Then use a graduated cylinder to accurately measure 40ml of Sr solution and 40ml of Ca solution and mix thoroughly, add 0.8g PEG-4000 (6% mass fraction), then add it into a three-necked flask, and turn on magnetic stirring to dissolve it vigorously. Under the ultrasonic water bath, the ultrasonic power is set to 100W, the working frequency is 53KHz, and the temperature of the water bath is controlled at 40°C. Use a constant pressure dropping funnel to put 80ml of (NH 4 ) 2 HPO 4 The solution was slowly added dropwise into the mixture of Sr and Ca, and reacted for 1.5h under ultrasonic stirring. After the reaction, the product was aged at room temperature for 12 hours, then washed with absolute ethanol several times and filtered with suction to obtain a white paste, which was put into a vacuum...

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Abstract

The invention relates to a method for preparing strontium-doped hydroxyapatite through supersound. The method comprises the following steps of (1) preparing Sr(NO3)2 solution, Ca(NO3)2 solution and (NH4)2HPO4 solution, and adjusting the pH value of the solutions to be between 10 and 11; (2) mixing the Sr(NO3)2 solution and the Ca(NO3)2 solution, adding PEG-4000 into the mixture, and stirring the mixture until the materials are dissolved to obtain mixed solution; (3) at the water-bath temperature of 20 to 60 DEG C, dropwise adding the (NH4)2HPO4 solution into the mixed solution, performing ultrasonic stirring reaction for 0.5 to 4 hours, standing and ageing a reaction product, washing the reaction product, and drying the reaction product under vacuum to obtain the strontium-doped hydroxyapatite. The strontium-doped hydroxyapatite can be used for absorbing heavy metal ions and target proteins, adding inorganic particles of a functional filtration film, water treatment and blood purification. The method is simple in process, convenient to operate and mild in condition. The prepared product is fine in particle and uniform in distribution and has excellent biological compatibility.

Description

technical field [0001] The invention belongs to the field of preparation of hydroxyapatite materials, in particular to a method for ultrasonically preparing strontium-doped hydroxyapatite. Background technique [0002] The molecular formula of hydroxyapatite (HAP) is Ca 10 (PO 4 ) 6 (OH) 2 , with a density of 3.16g / cm 3 , Brittle, the refractive index is 1.64-1.65. Slightly soluble in pure water, weakly alkaline, easily soluble in acid but hardly soluble in alkali. The crystal of hydroxyapatite belongs to the P63 / m space group, hexagonal crystal system, and the HAP existing in hard tissues such as animal bones and teeth is needle-shaped. Due to its good biocompatibility, low density, chemical stability and similar composition to human bone minerals, hydroxyapatite is widely used in bone replacement materials and biomedical engineering. [0003] Among the many excellent properties of HAP, its surface function, especially its adsorption performance, has attracted people...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/04B01J20/30B01J19/10
Inventor 孙俊芬曹伟烨陈莹何春菊
Owner DONGHUA UNIV
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