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215results about How to "Prevent coalescence" patented technology

Perfluorocarbon emulsions with non-fluorinated surfactants

A stable FC emulsion is described. The FC emulsion of the present invention comprises a continuous FC immiscible hydrophilic liquid phase and a dispersed phase comprising FC suspended as droplets within the continuous phase. The emulsion further comprises an emulsifying agent and a stabilizing agent. The stabilizing agent of the present invention reduces the ability of the FC droplets to move within the continuous phase. The present invention also provides a method of making a FC emulsion. The method comprises mixing an FC immiscible hydrophilic liquid and a solid emulsifying agent by agitation at a temperature elevated above the phase transition temperature of the emulsifying agent and below the boiling temperature of the FC immiscible hydrophilic liquid, and adding FC to the mixture of step (a) and agitating at the elevated temperature to disperse droplets of FC in the FC immiscible hydrophilic liquid to form the FC emulsion. The invention also provides another method of making an FC emulsion, which does not require a solid emulsifying agent. The method comprises mixing an FC immiscible hydrophilic liquid and an emulsifying agent to form a first mixture; mixing a stabilizing agent with the first mixture to form a second mixture; and mixing FC with the second mixture to form a third mixture to disperse droplets of FC in the FC immiscible hydrophilic liquid and to form the FC emulsion, wherein the stabilizing agent reduces ability of the droplets to move within a continuous phase of the FC emulsion.
Owner:OXYGEN EMULSION CO LLC

Andrographolide ground suspending liquid, preparation method thereof, and application of pharmaceutical preparation

The invention relates to andrographolide ground suspending liquid, a preparation method thereof, and the application of pharmaceutical preparation, which belongs to the field of pharmaceutical preparation. The preparation method comprises the steps of adding andrographolide into hydrophilic accessory solution with certain concentration, and grinding the andrographolide in a basket grinder to prepare suspending liquid with particle sizes smaller than 3000 nm. Liquid layers of pharmaceutical suspending liquid are laminated onto blank pellet cores with certain particle size range, to prepare andrographolide immediate-release pellets. After grinding, by reducing pharmaceutical particle sizes, increasing particle surface areas and improving the wettability of pharmaceutical particles, the dissolution in vitro of the drug is improved, and hydrophilic carriers are adopted to effectively prevent the aggregation of pharmaceutical particles so as to improve the stability of the pharmaceutical preparation. The preparation method is simple and easy for industrialized production, and the dissolving-out speed of the prepared andrographolide immediate-release pellets is high, so that the bioavailability is obviously improved.
Owner:SHENYANG PHARMA UNIVERSITY

Amphiphilic fluorine-containing gradient copolymer, and preparation method and application thereof

The invention discloses a preparation method of an amphiphilic fluorine-containing gradient copolymer, and the method is used in oil-water separation ultrafiltration membrane antifouling modification. First, with a reversible addition fragmentation chain transfer (RAFT) controlled free radical polymerization method, with a semi-continuous feeding manner, an amphiphilic fluorine-containing gradient copolymer is prepared; the prepared amphiphilic fluorine-containing gradient copolymer is adopted as a modifying agent, and is used for modifying the ultrafiltration membrane with a blending modification method, wherein the membrane is prepared with a classic non-solvent induced phase transformation method. The surface of the membrane modified with the amphiphilic fluorine-containing gradient copolymer has an amphiphilic hierarchical structure with the coexistence of hydrophilic and hydrophobic regions. The amphiphilic fluorine-containing gradient copolymer preparation method is simple; and the modified membrane preparation process has the advantages of easy operation and mild conditions. The modified membrane has good oil-water separation performance and excellent antifouling effect, and can be used in water treatment and especially the separation purification of oil-containing wastewater.
Owner:ZHEJIANG UNIV
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