Long-acting antibacterial multifunctional coating based on bionic dopamine as well as preparation method and application thereof
A multi-functional coating, dopamine technology, applied in the field of medical implantation and medical interventional materials, can solve the problems of instability and long coating deposition time
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[0026] In some embodiments of the present invention, the preparation method of the long-acting antibacterial multifunctional coating based on biomimetic dopamine of the present invention comprises: taking a certain amount of dopamine hydrochloride and dissolving it in Tris-HCl buffer solution, subsequently, adding Cu 2+ and H 2 o 2 After fully dissolving, the rapid deposition solution of dopamine is obtained; the substrate washed with acetone, absolute ethanol and ultrapure water in sequence is immersed in the rapid deposition solution of dopamine, and reacted for 10-120min to obtain polydopamine-coated Substrate, after the reaction is completed, the substrate is washed three times with deionized water; the substrate obtained above is placed in a vacuum or under normal pressure ventilation at 40-75°C for 4-48h; substance or amphoteric ion polymer multifunctional coating aqueous solution, soak the substrate treated above in the above multifunctional coating aqueous solution, ...
Embodiment 1
[0031] In this embodiment, the method of preparing a multifunctional coating is taken as an example with glass having a specification of 1 cm×2 cm as a substrate.
[0032] First, weigh 1 mg of dopamine hydrochloride and dissolve it in 50 mL of Tris-HCl buffer (pH = 7.5, 50 mM), then add CuSO 4 (5mM, 25mg) and H 2 o 2 (19.6mM, 0.2mL), after fully dissolving, a rapid deposition solution is obtained; the above cut glass is washed with acetone, absolute ethanol and ultrapure water in turn, and then quickly immersed in the above deposition solution for 30 minutes, then placed in a vacuum or Dry at 65°C for 4 hours under normal pressure and ventilation;
[0033] Then, weigh 0.02g of PEG-NH 2 Dissolve in 10 mL Tris-HCl buffer solution (pH value = 7.5, 50 mM), soak the washed and dried glass piece in the above aqueous solution, and react for 1 h.
[0034] Finally, wash the above-mentioned treated glass sheet with ultrapure water for more than three times, and then dry it at 65° C....
Embodiment 2
[0037] In this embodiment, the method of preparing a multifunctional coating is taken as an example by using quartz with a size of 1 cm×2 cm as the base material.
[0038] First, weigh 2 mg of dopamine hydrochloride and dissolve it in 50 mL of Tris-HCl buffer (pH = 7.5, 50 mM), then add CuSO 4 (5mM, 30mg) and H 2 o 2 (19.6mM, 0.5mL), after fully dissolving, a rapid deposition solution was obtained; the cut quartz sheet was washed with acetone, absolute ethanol and ultrapure water in sequence, and then quickly immersed in the above deposition solution for 20 minutes, then placed in a vacuum or Dry at 65°C for 4 hours under normal pressure and ventilation.
[0039] Then, weigh 0.04g of PEG-NH 2 Dissolve in 10 mL Tris-HCl buffer solution (pH value = 7.5 50 mM), soak the washed and dried quartz plate in the above aqueous solution, and react for 1 h.
[0040] Finally, wash the above-mentioned treated quartz sheet with ultrapure water for more than three times, and then dry it a...
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Abstract
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