Long-acting antibacterial multifunctional coating based on bionic dopamine as well as preparation method and application thereof

Abstract

The invention provides a long-acting antibacterial multifunctional coating based on bionic dopamine as well as a preparation method and an application thereof. The preparation method comprises the following steps: carrying out ultrasonic cleaning on a base material by using acetone, absolute ethyl alcohol and ultrapure water in sequence; immersing the obtained base material into dopamine rapid deposition liquid for reaction to obtain a base material coated with a polydopamine coating; washing the obtained base material with deionized water, and drying; soaking the obtained base material in a multifunctional coating aqueous solution for reaction, and obtaining a functional coating on the surface of the base material; washing the obtained base material with ultrapure water and then drying; wherein Cu<2+> and H2O2 are dissolved in the dopamine rapid deposition liquid, and the multifunctional coating aqueous solution contains a hydrophilic polymer or a zwitterionic polymer. The preparation process is simple, conditions are mild, deposition preparation time is greatly shortened, and the method is suitable for large-scale industrial production.

Description

technical field

[0001] The invention relates to the field of medical implant and medical intervention materials, in particular to a long-acting antibacterial multifunctional coating based on bionic dopamine and its preparation method and application Background technique

[0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art.

[0003] Blood-contacting materials are widely used in cardiovascular applications. When blood comes into contact with implanted or interventional materials, the surface of the material is prone to induce thrombus and infection, which severely limits its application. According to incomplete statistics, 250,000 people in intensive care units in the United States suffer from blood infectio...