Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Long-acting antibacterial multifunctional coating based on bionic dopamine as well as preparation method and application thereof

A multi-functional coating, dopamine technology, applied in the field of medical implantation and medical interventional materials, can solve the problems of instability and long coating deposition time

Pending Publication Date: 2021-04-30
SHANDONG UNIV
View PDF5 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the deficiencies in the prior art, the present invention provides a long-acting antibacterial multifunctional coating based on bionic dopamine and its preparation method and application. The preparation method of the present invention not only incorporates Cu 2+ It is applied in the coating, and solves the problem of long and unstable coating deposition time. The prepared coating surface has excellent stability and antibacterial properties, and has good hydrophilicity and biocompatibility. The introduction of functional polymers constructs the coating as a multifunctional coating combining biological inertness and slow-release bactericide. The coating can also inhibit the adsorption of non-specific proteins in the blood on the surface of the substrate, effectively reducing the formation of thrombus

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] In some embodiments of the present invention, the preparation method of the long-acting antibacterial multifunctional coating based on biomimetic dopamine of the present invention comprises: taking a certain amount of dopamine hydrochloride and dissolving it in Tris-HCl buffer solution, subsequently, adding Cu 2+ and H 2 o 2 After fully dissolving, the rapid deposition solution of dopamine is obtained; the substrate washed with acetone, absolute ethanol and ultrapure water in sequence is immersed in the rapid deposition solution of dopamine, and reacted for 10-120min to obtain polydopamine-coated Substrate, after the reaction is completed, the substrate is washed three times with deionized water; the substrate obtained above is placed in a vacuum or under normal pressure ventilation at 40-75°C for 4-48h; substance or amphoteric ion polymer multifunctional coating aqueous solution, soak the substrate treated above in the above multifunctional coating aqueous solution, ...

Embodiment 1

[0031] In this embodiment, the method of preparing a multifunctional coating is taken as an example with glass having a specification of 1 cm×2 cm as a substrate.

[0032] First, weigh 1 mg of dopamine hydrochloride and dissolve it in 50 mL of Tris-HCl buffer (pH = 7.5, 50 mM), then add CuSO 4 (5mM, 25mg) and H 2 o 2 (19.6mM, 0.2mL), after fully dissolving, a rapid deposition solution is obtained; the above cut glass is washed with acetone, absolute ethanol and ultrapure water in turn, and then quickly immersed in the above deposition solution for 30 minutes, then placed in a vacuum or Dry at 65°C for 4 hours under normal pressure and ventilation;

[0033] Then, weigh 0.02g of PEG-NH 2 Dissolve in 10 mL Tris-HCl buffer solution (pH value = 7.5, 50 mM), soak the washed and dried glass piece in the above aqueous solution, and react for 1 h.

[0034] Finally, wash the above-mentioned treated glass sheet with ultrapure water for more than three times, and then dry it at 65° C....

Embodiment 2

[0037] In this embodiment, the method of preparing a multifunctional coating is taken as an example by using quartz with a size of 1 cm×2 cm as the base material.

[0038] First, weigh 2 mg of dopamine hydrochloride and dissolve it in 50 mL of Tris-HCl buffer (pH = 7.5, 50 mM), then add CuSO 4 (5mM, 30mg) and H 2 o 2 (19.6mM, 0.5mL), after fully dissolving, a rapid deposition solution was obtained; the cut quartz sheet was washed with acetone, absolute ethanol and ultrapure water in sequence, and then quickly immersed in the above deposition solution for 20 minutes, then placed in a vacuum or Dry at 65°C for 4 hours under normal pressure and ventilation.

[0039] Then, weigh 0.04g of PEG-NH 2 Dissolve in 10 mL Tris-HCl buffer solution (pH value = 7.5 50 mM), soak the washed and dried quartz plate in the above aqueous solution, and react for 1 h.

[0040] Finally, wash the above-mentioned treated quartz sheet with ultrapure water for more than three times, and then dry it a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Concentrationaaaaaaaaaa
Concentrationaaaaaaaaaa
Login to View More

Abstract

The invention provides a long-acting antibacterial multifunctional coating based on bionic dopamine as well as a preparation method and an application thereof. The preparation method comprises the following steps: carrying out ultrasonic cleaning on a base material by using acetone, absolute ethyl alcohol and ultrapure water in sequence; immersing the obtained base material into dopamine rapid deposition liquid for reaction to obtain a base material coated with a polydopamine coating; washing the obtained base material with deionized water, and drying; soaking the obtained base material in a multifunctional coating aqueous solution for reaction, and obtaining a functional coating on the surface of the base material; washing the obtained base material with ultrapure water and then drying; wherein Cu<2+> and H2O2 are dissolved in the dopamine rapid deposition liquid, and the multifunctional coating aqueous solution contains a hydrophilic polymer or a zwitterionic polymer. The preparation process is simple, conditions are mild, deposition preparation time is greatly shortened, and the method is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to the field of medical implant and medical intervention materials, in particular to a long-acting antibacterial multifunctional coating based on bionic dopamine and its preparation method and application Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Blood-contacting materials are widely used in cardiovascular applications. When blood comes into contact with implanted or interventional materials, the surface of the material is prone to induce thrombus and infection, which severely limits its application. According to incomplete statistics, 250,000 people in intensive care units in the United States suffer from blood infectio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L31/10A61L31/14A61L31/16A61L27/34A61L27/54A61L27/58A61L33/06
CPCA61L31/10A61L31/16A61L31/148A61L27/34A61L27/54A61L27/58A61L33/068A61L2300/404A61L2300/608A61L2300/42A61L2300/204A61L2420/08A61L2420/06C08L79/04
Inventor 曹成波朱忠强王佰亮张春莲杨帆王琳
Owner SHANDONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com