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Carrageenan-based self-anticoagulant heparitin microsphere, as well as preparation method and application thereof

A technology of carrageenan and microspheres, which is applied in the direction of microsphere preparation, microcapsule preparations, chemical instruments and methods, etc., can solve the problems of increased treatment costs, low adsorption capacity, and massive bleeding in patients, and achieve excellent biocompatibility, Excellent adsorption performance and low cytotoxicity

Active Publication Date: 2018-09-14
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, natural polysaccharide materials generally have poor strength and low adsorption capacity, which limits their application.
In addition, during traditional hemoperfusion therapy, injection of heparin is required to prevent blood clotting, which not only increases the cost of treatment, but also puts patients at risk of other side effects such as massive bleeding

Method used

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  • Carrageenan-based self-anticoagulant heparitin microsphere, as well as preparation method and application thereof
  • Carrageenan-based self-anticoagulant heparitin microsphere, as well as preparation method and application thereof
  • Carrageenan-based self-anticoagulant heparitin microsphere, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The raw materials used in this example are calculated in parts by weight. The preparation process of self-anticoagulant heparin-like microspheres based on carrageenan in this example is as follows:

[0045] (1) Add 2 parts of carrageenan to 98 parts of deionized water at 70°C under stirring conditions, and stir for 4 hours to dissolve the carrageenan to obtain an aqueous solution of carrageenan;

[0046] (2) Dissolve 0.1 part of sodium lauryl sulfate in 100 parts of potassium chloride solution with a concentration of 0.3mol / L to obtain a potassium chloride solution containing sodium lauryl sulfate; switch on the power supply connected to the heating belt , maintain the temperature of the liquid storage tank at 70 ° C, put the carrageenan aqueous solution into the liquid storage tank of the microsphere preparation device, then operate the gas control valve to apply air pressure to the liquid level in the liquid storage tank through the air compressor, and open the liquid ...

Embodiment 2

[0051] The raw materials used in this example are calculated in parts by weight. The preparation process of self-anticoagulant heparin-like microspheres based on carrageenan in this example is as follows:

[0052] (1) Add 3 parts of carrageenan to 97 parts of deionized water at 70°C under stirring conditions, and stir for 3 hours to dissolve the carrageenan to obtain an aqueous solution of carrageenan;

[0053] (2) 0.08 part of sodium lauryl sulfate is dissolved in the potassium chloride solution of 100 parts of concentration 0.3mol / L, obtains the potassium chloride solution containing sodium lauryl sulfate; Switch on the power supply that is connected with heating belt , maintain the temperature of the liquid storage tank at 70 ° C, put the carrageenan aqueous solution into the liquid storage tank of the microsphere preparation device, then operate the gas control valve to apply air pressure to the liquid level in the liquid storage tank through the air compressor, and open th...

Embodiment 3

[0058] The raw materials used in this example are calculated in parts by weight. The preparation process of self-anticoagulant heparin-like microspheres based on carrageenan in this example is as follows:

[0059] (1) Add 1 part of carrageenan to 99 parts of deionized water at 60°C with stirring, and stir for 2 hours to dissolve the carrageenan to obtain an aqueous solution of carrageenan;

[0060] (2) 0.06 part of sodium lauryl sulfate is dissolved in the potassium chloride solution of 100 parts of concentration 0.3mol / L, obtains the potassium chloride solution containing sodium lauryl sulfate; Switch on the power supply that is connected with heating belt , maintain the temperature of the liquid storage tank at 60 ° C, put the carrageenan aqueous solution into the liquid storage tank of the microsphere preparation device, then operate the gas control valve to apply air pressure to the liquid level in the liquid storage tank through the air compressor, and open the liquid The...

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Abstract

The invention discloses a carrageenan-based self-anticoagulant heparitin microsphere, as well as a preparation method and application thereof. The carrageenan-based self-anticoagulant heparitin microsphere comprises a carrageenan microsphere of a network structure and a polyacrylic acid crosslinked network constructed by a crosslinking agent and interspersed with a carrageenan microsphere network.The microsphere is low in cytotoxicity and high in biocompatibility and anticoagulant property and has a structure and functional group similar to anticoagulant heparitin. The interspersed carrageenan network and polyacrylate crosslinked network form double networks and the double networks are restricted by each other, so that the mechanical strength of the microsphere is strengthened, the swelling rate is limited, breakage of the microsphere in a using process can be effectively avoided, the dimensional stability of the microsphere can be maintained in use and the microsphere is a novel adsorption material with application prospect for a hemoditoxifier.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and relates to a heparin-like microsphere prepared based on carrageenan, a preparation method and application thereof. Background technique [0002] Hemoperfusion technology, which purifies the blood by filtering the patient's blood outside the body and removing exogenous or endogenous toxins, has become a treatment for heavy metal poisoning, hyperlipidemia, hyperbilirubinemia, endotoxemia and uremia. One of the most effective methods for diseases such as [0003] The core of hemoperfusion technology lies in the adsorption materials. Research and preparation of new adsorption materials with good blood compatibility, low cytotoxicity, high adsorption selectivity, high adsorption capacity and high adsorption efficiency are the key to the development of hemoperfusion technology. Therefore, it has received extensive attention from many researchers. Activated carbon, a traditional adsor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/18C08F220/06C08F222/38C08F2/48B01J13/02B01J20/22B01J20/26B01J20/28C08L5/00
CPCB01J13/02B01J20/22B01J20/267B01J20/28019C08F2/48C08F220/06C08J7/18C08J2305/00C08J2433/02C08F222/385
Inventor 赵长生宋昕赵雯欣赵伟锋纪海锋张曼王康孙树东
Owner SICHUAN UNIV
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