6results about How to "Improve anticoagulant performance" patented technology

The construction method comprises the following steps: performing decellularization treatment on a pig heart aorta blood vessel, compounding the treated pig heart aorta blood vessel with polyvinyl alcohol and methacryloylated gelatin to prepare a pre-gel solution, printing a designed model into a hollow tubular mold by using white resin through 3D printing, and preparing the hollow tubular mold into the artificial blood vessel stent with the anticoagulation performance. Injecting the pre-gel solution into a mold for cross-linking to obtain an artificial blood vessel stent with controllable shape and size, and finally loading an anticoagulant drug heparin on the prepared stent to obtain the heparin-loaded artificial blood vessel stent. Materials for preparing the pre-gel solution are selected, and advantage complementation of material functions can be achieved. The acellular matrix is beneficial to adhesion, proliferation and differentiation of cells; the composite polyvinyl alcohol and methacrylated gelatin improve the mechanical properties of the scaffold and improve the cell adhesion. Heparin is loaded on the artificial blood vessel stent to improve the anticoagulation performance of the stent and prevent thrombus. As an excellent biomedical material, the stent has a wide application prospect in the related fields of cardiovascular tissue engineering and biology.

This invention relates to the field of biomedicine, specifically to the application of banana fruit extract in the preparation of anticoagulant or antithrombotic drugs. The banana fruit extract provided by this invention contains flavonoids, polyphenols, polysaccharides, hydroxyanthraquinones, triterpenoids, and other components. Flavonoids and polyphenols have been widely proven to have anti-inflammatory and antioxidant effects, which can synergistically enhance the anticoagulant effect. The high potassium content of banana fruit can indirectly improve vascular function by regulating sodium-potassium balance. The banana fruit extract provided by this invention can inhibit platelet production or promote platelet metabolism, prolong clotting time, and inhibit platelet aggregation. Its natural plant components interfere with platelet aggregation by inhibiting the production of thromboxane A2, achieving anticoagulant and antithrombotic effects. The mechanism of action of banana fruit extract differs from traditional anticoagulants such as heparin, reducing the risk of bleeding. Its natural component characteristics provide a direction for the development of novel plant-derived anticoagulant drugs.

The present invention relates to an adsorbent for improving anticoagulation effect, comprising a carrier and a biomimetic material modified on the carrier, wherein the carrier is a porous polymer cross-linked with styrene-divinylbenzene, and the biomimetic material is a derivative of 3-hydroxybicyclo[3,3,0]heptane containing hydroxyl and / or carboxyl groups. The present invention adopts an anticoagulation method different from the existing conventional one, by chemically modifying the surface of the polymer carrier with a group that is beneficial to reducing platelet aggregation, without coating the surface of the carrier, thereby obtaining an adsorbent for the field of blood purification with good anticoagulation effect.

The invention provides a resin carbon microsphere with an anticoagulation effect as well as a preparation method and application of the resin carbon microsphere. Vinyltriethoxysilane and acrylic acid are used as monomers, free radical polymerization reaction is initiated in the presence of azodiisobutyronitrile and triethyl phosphate, poly (vinyltriethoxysilane / acrylic acid) is obtained, the obtained polymer is covalently grafted on the surfaces of hydroxylated resin carbon microspheres by further utilizing hydrolytic condensation reaction, and the carbon microspheres are prepared. The resin carbon microsphere adsorbent with the anticoagulation effect is obtained. The adsorbent has good blood compatibility and cell compatibility, the polymer can be stably connected to the surfaces of the resin carbon microspheres under the action of covalent bonds, good anticoagulant stability is shown, and a modification material retains the adsorption capacity of original resin carbon microspheres to small and medium molecular toxins, so that the adsorption capacity of the resin carbon microspheres to the small and medium molecular toxins is improved. The adsorption capacity of macromolecular toxin lysozyme and the retention rate of bovine serum albumin are remarkably improved, good adsorption performance is shown, and potential clinical application prospects are achieved in the field of blood purification.

The invention discloses a preparation method of sulfated boletus nigrum polysaccharide and an application of the sulfated boletus nigrum polysaccharide in surface modification of a medical material, and the sulfated boletus nigrum polysaccharide is applied to surface modification of the medical material by adopting a sulfur trioxide pyridine method to modify a polysaccharide molecule with a sulfuric acid group to achieve the purpose of sulfating the polysaccharide. When the sulfated boletus nigrum polysaccharide is subjected to actual biological activity detection, the oxidation resistance, the anticoagulant property, the antibacterial property and the anti-inflammatory property of the sulfated boletus nigrum polysaccharide are improved compared with those of the boletus nigrum polysaccharide before sulfating modification, and after the surface of a medical material is modified, the medical material is more stable.

The invention discloses a fusion polypeptide and a PCL (polycaprolactone) stent material with an antibacterial and anticoagulant dual-functional coating. The PCL stent material with the antibacterial and anticoagulant dual-functional coating comprises a PCL fiber stent, a dopamine coating and a fusion polypeptide coating, the dopamine coating is arranged on the surface of the PCL fiber scaffold, and the fusion polypeptide coating is arranged on the surface of the dopamine coating. Dopamine is loaded on the surface of the PCL fiber scaffold, and a fusion polypeptide containing a hirudin sequence and an antibacterial polypeptide HHC36 sequence is fixed on the surface by utilizing a condensation reaction between amino and carboxyl, so that the scaffold material can stably prevent thrombus and resist bacteria for a long time. The method is simple and feasible in process and good in repeatability.