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Sulfonated citric acid chitosan modified polysulfone hemodialysis film and preparation method thereof

A sulfonated citric acid, chitosan modification technology, applied in chemical instruments and methods, semi-permeable membrane separation, membranes, etc., can solve the problems of easy blood pollution, poor chemical stability, etc., and achieve good mechanical properties and biological Compatibility, excellent hydrophilicity, anti-protein adsorption and anticoagulant improved effect

Active Publication Date: 2020-02-07
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above-mentioned blending method and coating method for modifying polysulfone hemodialysis membrane materials are all physical methods to improve the performance of polysulfone, which has poor chemical stability and is prone to blood pollution during hemodialysis; Most of the above-mentioned chemical surface modifications are achieved by directly introducing hydrophilic groups or grafting hydroxyl-containing heparin-like substances on the surface of polysulfone to improve the anticoagulant effect of polysulfone.

Method used

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  • Sulfonated citric acid chitosan modified polysulfone hemodialysis film and preparation method thereof
  • Sulfonated citric acid chitosan modified polysulfone hemodialysis film and preparation method thereof
  • Sulfonated citric acid chitosan modified polysulfone hemodialysis film and preparation method thereof

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Effect test

Embodiment 1

[0023] Add 18% of sulfonated citric acid chitosan modified polysulfone (mass fraction, the same below), 42% of N,N-dimethylformamide, and 40% of N,N-dimethylacetamide to the raw material tank , stirred at 25°C for 15 hours, after being fully dissolved, let it stand at room temperature for 18 hours to defoam, and a uniform film solution was obtained;

[0024] Open the nitrogen valve, maintain the pressure of the raw material tank at 0.20MPa, filter the modified polysulfone membrane liquid, and press it into the spinning head through the metering pump, control the flow rate of the membrane liquid to 1.15mL / min, and feed the core liquid at the same time, the flow rate is 1.09mL / min; the nascent film enters the coagulation bath and rinsing bath under the traction of the winding machine after passing through the air gap of 10cm, and then is wound on the drum; the winding speed is 45m / min, and the temperature of the coagulation bath is 28°C , the temperature of the rinsing bath was...

Embodiment 2

[0026] Add 20% (mass fraction, the same below) of sulfonated citric acid chitosan modified polysulfone and 80% N,N-dimethylacetamide into the raw material tank, stir at 25°C for 12 hours, and wait until fully dissolved , standing at room temperature for 18 hours to obtain a uniform membrane solution;

[0027] Open the nitrogen valve, maintain the pressure of the raw material tank at 0.10MPa, filter the modified polysulfone membrane liquid, and press it into the spinning head through the metering pump, control the flow rate of the membrane liquid to 1.03mL / min, and feed the core liquid at the same time, the flow rate is 1.01mL / min; the nascent film enters the coagulation bath and rinsing bath under the traction of the winding machine after passing through the air gap of 15cm, and then is wound on the drum; the winding speed is 36m / min, and the coagulation bath temperature is 20℃ , the temperature of the rinsing bath was 15°C; the obtained sulfonated citrate-chitosan modified p...

Embodiment 3

[0029] Add sulfonated citric acid chitosan modified polysulfone 15% (mass fraction, the same below), N-methylpyrrolidone 42%, N,N-dimethylacetamide 43%, into the raw material tank, at 25 ℃ Stir at low temperature for 15 hours. After fully dissolving, let stand at room temperature for defoaming for 18 hours to obtain a uniform film liquid;

[0030] Open the nitrogen valve, maintain the pressure of the raw material tank at 0.18MPa, filter the modified polysulfone membrane liquid, and press it into the spinning head through the metering pump, control the flow rate of the membrane liquid to 1.11mL / min, and feed the core liquid at the same time, the flow rate is 1.08mL / min; the nascent film enters the coagulation bath and rinsing bath under the traction of the winding machine after passing through the air gap of 18cm, and then is wound on the drum; the winding speed is 50m / min, and the coagulation bath temperature is 30℃ , the temperature of the rinsing bath was 30°C; the polysulfon...

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Abstract

The invention discloses a sulfonated citric acid chitosan modified polysulfone hemodialysis film and a preparation method thereof. Sulfonated citric acid chitosan modified polysulfone (SCACS-PSF) is used as a film material, the mass percentage content of a film solution is 15-25%, the mass percentage content of a solvent is 75-85%, and the sulfonated citric acid chitosan modified polysulfone hemodialysis film with good biocompatibility is prepared by a dry-wet spinning method. The asymmetric hemodialysis film prepared by the invention has a hollow fiber structure; the inner and outer surfacesare compact skin layers; the middle supporting layer is porous; the hemodialysis film has an inner diameter of 130-260 microns, a wall thickness of 20-60 [mu] m, and an ultrafiltration coefficient of5 to 55 mL / m < 2 >. H.mmHg; the hemodialysis film is a film module which has high permeability and high separability; the hemodialysis film has good anticoagulation and antibacterial properties, the removal rates of urea, beta-microglobulin and albumin are 58%-85%, 50%-62% and 3.0%-9.8% respectively, the removal rate of pathogenic escherichia coli is 99%, and the removal rate of staphylococcus aureus is 99.5%-100%.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a sulfonated citrate chitosan modified polysulfone hemodialysis membrane and a preparation method thereof. Background technique [0002] The main chain of polysulfone is composed of multiple sulfone groups, phenyl groups and ether bonds. The conjugation effect of sulfone groups, the combined effect of ether chains and benzene rings make it have excellent oxidation resistance, thermal stability, flexibility and processability Therefore, polysulfone is a kind of thermoplastic polymer elastomer material with great potential. At the same time, polysulfone membranes are resistant to cleaning and can be reused after formation, and have better transmission performance. Compared with cellulose hollow fiber membranes, polysulfone hollow fiber membranes have a higher removal rate for middle molecular solutes. Widely used in the field of biomedicine. However, in clinical diagnosis and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68B01D69/02B01D69/08B01D61/24B01D67/00
CPCB01D61/243B01D67/0011B01D67/0016B01D69/02B01D69/08B01D71/68B01D2325/022B01D2325/24B01D2325/36B01D2325/48
Inventor 邱运仁林秉贤王灿
Owner CENT SOUTH UNIV
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