Micro-nano multi-scale patterned anticoagulation composite biological material and method for preparing same

A composite biomaterial and anticoagulation technology, applied in the field of composite biomaterials and their preparation, can solve the problems of insufficient biocompatibility for medical applications, poor mechanical properties, etc., and achieve the effect of improving anticoagulant performance and reducing thrombus.

Inactive Publication Date: 2012-05-09
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to overcome the problems that current implanted materials in the body are unstable in the body fluid environment, have poor mechanical properties, and are not excellent enough in biocompatibility to limit their medical applications, the purpose of the present invention is to provide a material made of TiO 2 A multi-scale micro-nano pattern composite functional material composed of nanowires and amorphous carbon films can be used as a biomaterial or coating for implanting biological devices in the human body, which can be in contact with blood and can exhibit good resistance coagulation performance

Method used

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  • Micro-nano multi-scale patterned anticoagulation composite biological material and method for preparing same
  • Micro-nano multi-scale patterned anticoagulation composite biological material and method for preparing same
  • Micro-nano multi-scale patterned anticoagulation composite biological material and method for preparing same

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preparation example Construction

[0030] TiO of the present invention 2 The preparation method of nanowire / amorphous carbon film composite material comprises the following process steps:

[0031] 1) First, use photolithography technology to lithographically pattern the designed patterns of various micron-scale specifications (such as figure 1 shown), transferred to a photosensitive adhesive-coated fluorinated conductive glass (FTO) or metal titanium substrate, and etched to obtain a pattern consistent with the mask.

[0032] 2) Next, put the above-mentioned patterned FTO or metal titanium substrate into the reaction kettle, and grow titanium dioxide nano-arrays by hydrothermal synthesis. The array as a whole presents a micro-nano pattern structure, showing microphase separation, and its hydrophilicity and hydrophobicity change greatly, and it is also easy to attach to amorphous carbon. Due to TiO 2 Nanowires can only be selectively grown in micron-scale pattern areas, and TiO cannot be grown in areas withou...

Embodiment 1

[0041] Preparation of micro-nanoscale patterns by photolithography

[0042] By formulating a set of mask templates with pattern specifications ( figure 1 (a)~ figure 1 As shown in (d), such as: a dot matrix pattern with a diameter and pitch of 1 micron, a line width: a parallel line array pattern with a pitch of 1:1.5 microns, a dot matrix pattern of 0.5 micron×1 micron, or their inversion picture. The pattern of the mask plate is transferred and prepared on the fluorinated conductive glass (FTO) by conventional photolithography technology or screen printing technology, and finally a fluorinated conductive glass FTO substrate pattern corresponding to the pattern of the mask plate is obtained.

Embodiment 2

[0044] Preparation of TiO by Hydrothermal Synthesis 2 Nanowire Array Micro-Nano Pattern Structure

[0045] On the fluorinated conductive glass or titanium metal substrate with micron-scale pattern structure, the hydrothermal synthesis method is used to selectively synthesize TiO in the pattern area 2 nanoarray. TiO with different diameters and different nanowire densities can be prepared by changing the concentration of the reaction solution, reaction temperature, and growth time. 2 Nano-array, the typical process is: butyl titanate 0.5ml (purity 98%), reaction time 0.5 hours, reaction temperature 150°C, hydrochloric acid: deionized water volume ratios are 15 / 25, 18 / 23, 20 / 20 , 23 / 18.

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Abstract

The invention discloses a micro-nano multi-scale patterned anticoagulation composite biological material and a method for preparing the same. The micro-nano multi-scale patterned anticoagulation composite biological material comprises a titanium dioxide (TiO2) nano-wire array and an amorphous carbon film wrapping the top end of the nano-wire array. The method for preparing the anticoagulation composite biological material includes the steps: firstly, arranging micron-sized patterns on a fluorine-doped tin oxide (FTO) conductive glass substrate through the mask plate photoetching technology, secondly, enabling the TiO2 nano-wire array to grow on the patterned substrate by means of hydro-thermal synthesis, and enabling the TiO2 nano-wire array to grow on a micron-sized patterned area, so that the whole TiO2 nano-wire array is in a micro-nano patterned structure, and finally, wrapping the amorphous carbon film on the prepared micro-nano patterned array. By the aid of composition of two materials and the design of the micro-nano patterned structure, properties such as surface appearance, hydrophilicity and hydrophobicity, electron transfer characteristic and the like of the materials can be changed and controlled, and blood compatibility of the composite material is improved.

Description

technical field [0001] The invention relates to a composite biomaterial and a preparation method thereof, belonging to the technical fields of biomedical engineering and biomaterials, in particular to an anticoagulant composite biomaterial with a micro-nano multi-scale pattern structure and a preparation method thereof. Background technique [0002] Biomaterials are a class of functional materials that can be used to diagnose, replace or repair damaged tissues or organs in living organisms. However, most of the biomaterials currently implanted in the body will cause a series of adverse physiological reactions. Therefore, in addition to developing new excellent In addition to materials, how to improve the biocompatibility of materials and apply them to actual medical materials has become a research hotspot and a formidable challenge in this field. The stability of the physical and chemical properties of biomaterials, as well as the pros and cons of biocompatibility, become th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B81B7/04B81C1/00
Inventor 陈弟虎何振辉罗平黄展云
Owner SUN YAT SEN UNIV
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