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Polyacrylonitrile-carboxymethyl chitosan composite hemodialysis membrane and preparation method thereof

A technology of carboxymethyl chitosan and polyacrylonitrile, which is applied in the field of biomedical materials and their preparation, can solve the problems of difficult melting, limitation, poor compatibility, etc., so as to improve comprehensive performance, improve hydrophilicity and biological phase Capacitance and the effect of improving anticoagulant properties

Active Publication Date: 2018-01-09
泉州市科茂利通智能科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among chitin and its derivatives, chitin has the lowest cost, but chitin has poor compatibility with some conventional fiber-forming polymers, especially chitin is difficult to melt and insoluble in water, dilute acid, dilute Alkali, concentrated alkali and general organic solvents, so the application in chemical fiber modification is limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A polyacrylonitrile-carboxymethyl chitosan composite hemodialysis membrane of the present embodiment is composed of the following components in parts by weight: 40 parts of polyacrylonitrile, 25 parts of carboxymethyl chitosan, 15 parts of polyacrylate 0.01 part of heparin, 45 parts of solvent, and 45 parts of water. Wherein the polyacrylonitrile is acrylonitrile homopolymer, the viscosity average molecular weight is 50000, and the solvent is acetone.

[0022] A kind of preparation method of polyacrylonitrile-carboxymethyl chitosan composite hemodialysis membrane of the present embodiment is carried out as follows:

[0023] A1. Dissolving polyacrylonitrile, polyacrylate, and heparin in a solvent to prepare a polyacrylonitrile solution with a mass fraction of 30-45%;

[0024] A2. carboxymethyl chitosan powder is dissolved in the solvent of polyacrylonitrile, is mixed with polyacrylonitrile-carboxymethyl chitosan spinning solution, leaves standstill defoaming;

[0025] ...

Embodiment 2

[0027] A polyacrylonitrile-carboxymethyl chitosan composite hemodialysis membrane of the present embodiment is composed of the following components in parts by weight: 35 parts of polyacrylonitrile, 20 parts of carboxymethyl chitosan, 10 parts of polyacrylate 0.005 parts of heparin, 32 parts of solvent, and 15 parts of water. Wherein the polyacrylonitrile is acrylonitrile homopolymer, the viscosity average molecular weight is 70000, and the solvent is dimethylacetamide.

[0028] A kind of preparation method of polyacrylonitrile-carboxymethyl chitosan composite hemodialysis membrane of the present embodiment is carried out as follows:

[0029] A1. Dissolving polyacrylonitrile, polyacrylate, and heparin in a solvent to prepare a polyacrylonitrile solution with a mass fraction of 30-45%;

[0030] A2. carboxymethyl chitosan powder is dissolved in the solvent of polyacrylonitrile, is mixed with polyacrylonitrile-carboxymethyl chitosan spinning solution, leaves standstill defoaming...

Embodiment 3

[0033] A polyacrylonitrile-carboxymethyl chitosan composite hemodialysis membrane of the present embodiment is composed of the following components in parts by weight: 50 parts of polyacrylonitrile, 30 parts of carboxymethyl chitosan, 18 parts of polyacrylate 0.02 parts of heparin, 60 parts of solvent, and 50 parts of water. Wherein the polyacrylonitrile is an acrylonitrile copolymer, the viscosity average molecular weight is 170000, and the solvent is dimethyl sulfoxide.

[0034] A kind of preparation method of polyacrylonitrile-carboxymethyl chitosan composite hemodialysis membrane of the present embodiment is carried out as follows:

[0035] A1. Dissolving polyacrylonitrile, polyacrylate, and heparin in a solvent to prepare a polyacrylonitrile solution with a mass fraction of 30-45%;

[0036] A2. After the carboxymethyl chitosan powder is made into an ultrafine powder, add it to the polyacrylonitrile solution to prepare a polyacrylonitrile-carboxymethyl chitosan spinning s...

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Abstract

The invention discloses a polyacrylonitrile-carboxymethyl chitosan composite hemodialysis membrane, which is prepared from the following components in parts by weight: 35 to 50 parts of polyacrylonitrile, 20 to 30 parts of carboxymethyl chitosan, 10 to 18 parts of polyacrylate, 0.005 to 0.02 part of heparin, 32 to 60 parts of solvent, and 15 to 50 parts of water. The invention also discloses a preparation method of the polyacrylonitrile-carboxymethyl chitosan composite hemodialysis membrane. Hydrophilic biomass carboxymethyl chitosan and anticoagulant heparin are introduced into the polyacrylonitrile through blended spinning, so that the hydrophilia and the biocompatibility of the polyacrylonitrile used as the hemodialysis membrane are improved, and meanwhile, a certain anticoagulation function is realized; the method is simple and practicable, rich in raw material source, low in price, and easy to popularize.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials and their preparation, and specifically relates to a polyacrylonitrile-carboxymethyl chitosan composite hemodialysis membrane and a preparation method thereof. Background technique [0002] The basic principles of blood purification therapy are dialysis, filtration, and adsorption. According to the basic principles, the purification materials used are mainly separation membranes and adsorbents. Using artificially synthesized polymer materials to remove harmful substances in the human body through blood purification therapy is one of the current research hotspots of biomedical blood purification materials. The development of efficient medical blood purification materials is a key factor in determining the efficacy of blood purification. [0003] Hemodialysis membrane uses the principle of semi-permeable membrane, with the help of the solute gradient, osmotic gradient and water pressure...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D67/00B01D69/02B01D71/42D01F8/08D01F8/18D01F8/10A61M1/16
Inventor 周中玉王忞马翠霞
Owner 泉州市科茂利通智能科技有限公司
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