43 results about "Haemodialysis membrane" patented technology

The present invention relates to a method of treating anemia especially in an EPO resistant hemodialysis patient, comprising hemodialysis with a high cut-off dialysis membrane, wherein the hemodialysis membrane is characterized in that it has a molecular weight cut-off in water, based on dextran sieving coefficients, of between 90 and 200 kD and a molecular weight retention onset in water, based on dextran sieving coefficients, of between 10 and 20 kD, and a ΔMW of between 90 and 170 kD. The invention further relates to a high cut-off hemodialysis membrane for the treatment of anemia in hemodialysis patients, especially EPO resistant hemodialysis patients.

The invention discloses a method for fixing heparin on polylactic acid hemodialysis membrane surface. Poly lactic acid has good biocompatibility, but has a certain of hydrophobicity, and hemodialysis membrane materials are often required to have a certain of hydrophilicity to reduce adsorption of protein and blood cells and prevent blood coagulation, so that hydrophilic modification is needed. Through use of the method of the invention, polylactic acid hemodialysis membrane surface can be modified through self-polymerization and attachment behaviors of dopamine, the heparin is covalently fixed on the membrane surface through a further reaction with heparin, and then a polylactic acid hollow fiber hematodialysis membrane having anticoagulation effect and good hydrophilicity is prepared. In the method, through utilization of the oxidation, self-polymerization, crosslinking adhesive properties of the dopamine, the heparin can be fixed on the membrane material surface. The prepared polylactic acid hollow fiber membrane has good hydrophilicity, biocompatibility, less adsorption of proteins and platelets, is not easy to cause hemolysis, and has more mild conditions than that of the prior art modification methods and obvious effects.

The invention relates to the technology of hematodialysis membranes, and aims at providing a method for preparing an amino acid modified polyether sulfone hematodialysis membrane. The method comprises the steps that chloromethyl group polyether sulfone, polarity aprotic organic solvent and a micromolecule pore-forming agent are taken and mixed to be stirred and dissolved to obtain a uniform and stable membrane casting solution; vacuum standing and bubble removing are carried out, and a chloromethyl group polyether sulfone hollow fiber membrane is prepared through a dry/wet phase inversion method and then immersed in hot water; finally, immersing is carried out through an ethanol solution, and drying is carried out; the chloromethyl group polyether membrane is immersed in a sodium hydroxide water solution to be reacted; the chloromethyl group polyether membrane is immersed in hot water; finally, the chloromethyl group polyether membrane is immersed in the ethanol solution, drying is carried out, and then the product is obtained. The chloromethyl group polyether sulfone hollow fiber membrane serves as a precursor material, and precise and controllable amidogen acidification modification can be carried out on the chloromethyl group polyether sulfone membrane through the electrophilic substitution policy. The polyether sulfone hematodialysis membrane modified through amino acid has the advantages of permanent hydrophilia, low-protein adsorbability and superior biocompatibility.

The method is featured as washing and extracting polymer film by alcohol, placing it in ammonium persulfate aqueous solution for forming peroxide perssad with activation initiating polymerization of vinyl monomer containing carboxy on surface by ferrisulphas ammonium, converting carboxyl to be end azyl by using 1-ethyl-3-(3-dimethyl propyl) EDC as cross-linking agent to react with a,W-aminopropyl-polyglycol and fixing heparin on polymer film surface by covalent bond through condensation of carboxyl and azyl in heparin structure.

The invention discloses a citric acid-chitosan-modified anticoagulation polyurethane blood dialysis membrane and a preparation method thereof. The membrane is of a hollow fibrous structure, and the inner surface and outer surface are dense cortical layers, and the middle is a porous supporting layer, so that the blood dialysis membrane is high in permeability and separating property and antibacterial property; the inner diameter is 160 to 250mu m; the membrane thickness is 30 to 50 mu m, and the ultrafiltration coefficient is 7.0 to 60 ml/m<2>.h.mmHg; citric acid-chitosan-modified anticoagulation polyurethane is taken as membrane materials, and in membrane solution, the percentage mass content of the modified anticoagulation polyurethane is 15 to 30%, and the percentage mass content of a solvent is 70 to 85%, and the blood dialysis membrane is prepared by using a nonsolvent induced phase separation method. The preparation process of the dialysis membrane is simple and easy to control, and the prepared membrane has good anticoagulant activity, biocompatibility and antibacterial property, and the clearance rates of urea, beta2-microglobulin and albumin are respectively 55 to 80%, 48 to 60%, and 2.5 to 9%, and the rate of resisting pathogenic escherichia coli is 99%.

The invention discloses a bacteria cellulose hemodialysis membrane and a preparation method of the bacteria cellulose hemodialysis membrane. The preparation method comprises the following steps of activating bacteria cellulose powder by a NaOH (sodium hydroxide) solution, then dissolving the bacteria cellulose powder in a LiCl/DMAC (lithium chloride/N, N-dimethylacetamide) solvent system under a heating condition, cooling the dissolving system, standing and scraping the membrane; slowly immersing a membrane scraping plate in a coagulating bath, standing, and taking the membrane scraping plate out of the coagulating bath after the membrane strips from the membrane scraping plate so as to obtain the bacteria cellulose regeneration membrane for hemodialysis. Bacteria cellulose is used as raw material, the regeneration cellulose membrane is prepared by an immersing, precipitating and phase conversion method, and then the regeneration cellulose membrane can be used as a novel hemodialysis membrane for treating acute and chronic renal failure. Compared with the traditional hemodialysis membrane, the bacteria cellulose hemodialysis membrane has the advantages that the chemical purity is high, the biocompatibility is high, the mechanical strength is high, the water ultrafiltering rate is high, the simple, environment-friendly, moderate and controllable effects are realized in the preparation process, and the bacteria cellulose hemodialysis membrane is suitable for the industrial production of the hemodialysis membranes with different requirements.

The invention discloses a bio-based hemodialysis membrane and a preparation method thereof. The hemodialysis membrane is prepared from polylactic acid, laminarin, thiolated chitosan, silk fibroin, sodium ascorbyl phosphate, cellulose acetate, dithiothreitol, stachyose, betulin caffeate, ammonium persulfate, ferulic acid, hydroxyethyl starch, N-benzyl glycine hydrochloride, deoxycholic acid, polyhydroxyalkanoate, hexamethylenediamine, hyaluronic acid, benzoperoxide and dimethyl sulfoxide. According to the prepared hemodialysis membrane, the tensile strength is not lower than 7.0 MPa, the transmittance of urea is higher than 86%, the transmittance of beta2 microglobulin is higher than 66%, the rejection rate of macromolecular protein is higher than 95%, the biocompatibility is good, coagulation, thrombus, inflammation, poisoning and other adverse reactions do not exist, and an application prospect is wide.

The invention relates to a preparation method for a hydrophilic polyacrylonitrile separation film. The method comprises the following steps: (1) taking acrylonitrile (AN) and hydroxyethyl methacrylate (HEMA) as reaction monomers and compounding into an amphipathic copolymer PAN-co-PHEMA; (2) taking the compounded PAN-co-PHEMA as a film material and adopting an immersing phase-inversion method for preparing a panel separating film; and (3) processing the PAN-co-PHEMA panel film with acryloyl chloride, introducing a carbon-carbon double bond into the film surface and further reacting with acryloyl morpholine (ACMO), thereby acquiring the hydrophilic polyacrylonitrile separation film. The hydrophilic ACMO with a repelling property to the protein adsorption is utilized to modify the PAN film, so that the PAN separation film with an excellent antifouling property is acquired. The technology is simple, and the cost is low. The hydrophily of the prepared modified film is better than that of pure PAN film, and the protein absorbed to the film surface is obviously reduced. The hydrophilic polyacrylonitrile separation film can be developed and used as a sewage processing separation film and a hemodialysis film.

The invention relates to a heparinoid-modified polyvinyl alcohol hydrogel thin nano-compound hematodialysis film and a preparation method thereof. A heparinoid hydrogel skin layer is arranged as an outer layer of a thin nano-compound hematodialysis film and a porous supporting layer with nano-pores communicated with each other is arranged as an inner layer of the thin nano-compound hematodialysis film. The preparation method comprises the following steps: performing electrostatic spinning on a PAN solution, thereby acquiring a nanometer fiber as the supporting layer of a compound film; adding sodium-hydrogen into the PVA solution, and then adding 1,3-propane sultone, reacting for 8-24h at 40-80 DEG C, filtering and drying, thereby acquiring s-PVA; mixing s-PVA with PVA, adding a solvent, adjusting pH, adding a cross-linking agent, coating on the supporting layer after cross-linking, and sealing at room temperature, thereby acquiring the heparinoid-modified polyvinyl alcohol hydrogel thin nano-compound hematodialysis film. The preparation method provided by the invention is simple in reaction process and is easily performed. The prepared thin nano-compound hematodialysis film has the characteristics of permanent hydrophily, low protein adsorbability and excellent biocompatibility.

The invention relates to a nanofiber-based composite hemodialysis membrane and a preparation method thereof. The preparation method includes the steps that a high-molecular polymer solution is subjected to electrostatic spinning, a nanofiber non-woven fabricis obtained, and subjected to cold pressing, and then a nanofiber porous supporting layer is obtained; after silk is subjected to degumming, dissolving, dialyzing, vulcanizing and self-assembling, a vulcanized silk fibroin protein nanowire precursor is obtained; a prepared vulcanized silk fibroin protein nanowire and polyvinyl alcohol are added into water; and then glutaric dialdehyde is added to be crosslinked, the mixture is coated in the nanofiber porous supporting layer, and the nanofiber-based composite hemodialysis membrane can beobtained after sealing at the room temperature. According to the preparation method of the nanofiber-based composite hemodialysis membrane, silk materials with the characteristics of low cost and wide sources are used for preparing the vulcanized silk fibroin protein nanowire, the process is simple, and implementation is easy; and the obtained nanofiber-based composite hemodialysis membrane has good water permeability, the excellent dialysis efficiency and anticoagulant activity.

The invention relates to a nano fiber composite hemodialysis membrane with a directional toxin removing passage and preparation thereof. A cortex of the hemodialysis membrane is a polyving akohol separation layer with a heparin functionalization carbon nanotube, and a supporting layer is a polyacrylonitrile nano fiber membrane. According to the hemodialysis membrane, the directional nano passage is provided for toxins by a nano clearance which is formed in the part between the heparin functionalization carbon nanotube and polyving akohol substrate in the cortex, and under the premise that macromolecular protein selectivity is not sacrificed, the composite hemodialysis membrane has the advantages of efficient micro and medium molecular toxin removing rate and excellent blood compatibility.

The invention discloses a polyacrylonitrile/cellulose acetate fiber composite hemodialysis membrane and a preparation method thereof, and relates to the field of biological materials. The hemodialysis membrane refers to a hollow fiber membrane, the average inner diameter of hollow fibers is 122-245 microns, and the wall thickness is 22-50 microns. The hemodialysis membrane comprises the following components in parts by mass: 35-60 parts of polyacrylonitrile fibers, 25-40 parts of cellulose acetate fibers, 3-7 parts of a coupling agent and 30-60 parts of solvents, wherein the solvents refer to acetone and DMAC or acetone and DMSO. In the method for preparing the polyacrylonitrile/cellulose acetate fiber composite hemodialysis membrane, a dry-wet preparation process is adopted. The polyacrylonitrile/cellulose acetate fiber composite hemodialysis membrane provided by the invention is relatively high in retention rate of bovine serum albumin, relatively high in biocompatibility, relatively high in permeability on vitamin B12 and relatively low in cost and is a relatively ideal hemodialysis membrane material.

The invention discloses a test method of the aperture distribution of a hemodialysis membrane. The method comprises the following steps: dissolving one or more solutes in ultrapure water to form a simulation solution, and filtering the simulation solution through the hemodialysis membrane; testing the concentration of corresponding solute molecular weight in the simulation solution and the concentration of corresponding solute molecular weight in a filtrate; calculating a curve of the molecular diameter of the corresponding solute molecular weight and the interception rate of the hemodialysis membrane; establishing the aperture distribution function and the accumulated distribution function of the hemodialysis membrane; and carrying out nonlinear fitting on the accumulated distribution function on practically measured interception rate curve data through least squares fitting analysis software, determining the aperture distribution parameter, and substituting the aperture distribution parameter into the aperture distribution function to obtain the aperture distribution of the hemodialysis membrane. The method is used to rapidly detect the aperture distribution of the hemodialysis membrane., and has the advantages of high accuracy of measured data, simplicity and high practicality.

The invention provides an alginate fiber hematodialysis membrane and a preparation method thereof, relating to the field of biological materials. The alginate fiber hematodialysis membrane is a hollow fiber membrane and comprises the following components in parts by weight: 20-35 parts of polyamide, 10-20 parts of alginate fiber, 3-8 parts of a toughening agent, 5-15 parts of polylactic acid and 30-60 parts of a solvent, wherein the average inner diameters of hollow fibers are 100-300 microns, and the wall thicknesses of the hollow fibers are 20-50 microns. According to the preparation method of the alginate fiber hematodialysis membrane, the alginate fiber hematodialysis membrane is prepared by virtue of a dry-wet method preparation process. According to the alginate fiber hematodialysis membrane, the hollow fiber membrane with good biocompatibility and high mechanical strength is prepared by virtue of the characteristic of high biocompatibility of the alginate fiber and the superiorities of the dry-wet method preparation process. By adjusting parameters in the dry-wet method preparation process, particularly the pressures of core liquid and a spinning solution tank, the prepared hollow fiber has large inner diameter and small wall thickness and is beneficial to the elimination of micromolecule toxin and the entrapment of macromolecule protein.

The present disclosure relates to a hemodialysis membrane for the treatment of hemolytic events, especially acute episodes of hemolysis which lead to elevated levels of plasma free hemoglobin. The present disclosure further relates to methods of removing hemoglobin from the blood of patients undergoing a hemolytic event. The treatment and method encompasses using a hemodialysis membrane which is characterized in that it comprises at least one hydrophobic polymer and at least one hydrophilic polymer and in that it has a MWRO of between 15 and 20 kD and a MWCO of between 170-320 kD, or, in the alternative, has a MWRO of between 9 and 14 kD and a MWCO of between 55 kD and 130 kD.

The invention relates to a method for preparing a hemodialysis membrane containing bamboo shoot fibers and belongs to the technical field of biopolymer materials. The method includes the following steps that firstly, bamboo shoot fiber powder is prepared; secondly, a primary mixed solution is prepared; thirdly, a spinning solution is prepared; fourthly, the spinning solution is placed in a spinning solution tank for vacuum defoaming; fifthly, spinning parameters are adjusted; sixthly, spinning starts, and the hemodialysis membrane containing bamboo shoot fibers is prepared. The hemodialysis membrane prepared through the method has good biocompatibility, adverse reactions in the dialysis process are overcome, and dialysis performance of the hemodialysis membrane is further improved.

The invention discloses a method for preparing an efficient blood coagulation resistant biomaterial with an aqueous solution. The aqueous solution has a self-assembly characteristic, is high in biochemistry activity, can form hydrogen bonds with anticoagulation/antithrombus medicines, and has the characteristic of being firmly attached to the biomaterial, so that the surface of the biomaterial (such as a blood purification film, a blood purification pipeline, a cardiovascular stent and an artificial blood vessel) has anticoagulation/antithrombus activity. The surface modification process disclosed by the invention is simple in experimental condition, high in controllability, economical and environment-friendly; and the aqueous solution is high in shaping properties, so that the aqueous solution is basically suitable for anticoagulation/antithrombus modification of the surface of the biomaterial in any shape. The dopamine hydrochloride aqueous solution is prepared, a micromolecule anticoagulant medicine-argatroban is grafted to the surface of a haemodialysis film, the haemodialysis film having anticoagulation/antithrombus activity is successfully prepared, the usage of a whole bodyanticoagulant is reduced or avoided, and the bleeding risk of a haemodialysis patient is reduced.

The invention relates to a sulfonated dihydroxypropyl chitosan modified polyurethane (SDHPCS-PU) hemodialysis membrane and a preparation method thereof. The preparation method comprises the steps of adding 10-20% of SDHPCS-PU and 80-90% of a solvent into a dissolving kettle, controlling the temperature to be 70-90 DEG C, and stirring for 2-20 h; after the materials are completely dissolved, standing for 10-20 h for completing defoaming so as to obtain membrane liquid; after that, adopting a dry-wet spinning method to prepare the SDHPCS-PU hemodialysis membrane. The preparation method providedby the invention has the characteristic that the high-performance hemodialysis membrane is prepared by utilizing the good physical and chemical properties and blood compatibility of the SDHPCS-PU. Themembrane production process provided by the invention is simple and easy to operate.

The invention relates to a preparation method of a hemodialysis membrane with high anticoagulant performance, so as to reduce the coagulation phenomenon during the use of the dialysis membrane. The present invention takes the polysulfone hemodialysis membrane as the modification target, first prepares a triblock copolymer containing polysulfone or polyethersulfone and acrylic acid through atom transfer radical polymerization, then blends the copolymer with polysulfone, spins, Preparation of polysulfone hemodialysis membrane. The carboxyl group on the surface of the dialysis membrane is used to graft heparin onto the surface of the dialysis membrane to improve the hydrophilicity and anticoagulant performance of the dialysis membrane. The invention is easy to operate and effectively relieves the coagulation problem during the use of the hemodialysis membrane. The surface hydrophilicity of the prepared hemodialysis membrane is obviously improved, and the anticoagulant ability is obviously improved.

The invention provides a rare earth element containing hemodialysis membrane and a preparation method thereof, and relates to the field of biological materials. The hemodialysis membrane is a hollow fiber membrane and is 150 to 250 microns in average internal diameter and 28 to 46 microns in wall thickness. The hemodialysis membrane is prepared from the following components in parts by mass: 35 to 55 parts of polysulfone, 12 to 20 parts of diacetate fiber, 0.1 to 0.5 part of nanometer samarium chloride, 4 to 10 parts of a flexibilizer, and 25 to 50 parts of a solvent. The preparation method of the rare earth element containing hemodialysis membrane adopts a dry-wet preparation process. The rare earth element containing hemodialysis membrane is outstanding in biocompatibility, high in macromolecular protein intercepting performance and relatively high in small solute transmissivity, and is an ideal hemodialysis membrane material.