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A hemodialysis membrane with high anticoagulant performance and its preparation method

A technology for hemodialysis and coagulation, applied in semipermeable membrane separation, chemical instruments and methods, membrane technology, etc., can solve the problems of difficult chemical modification, good chemical stability of polymer membrane materials, and difficult surface modification of separation membranes. Easy to operate, improve hydrophilicity and anticoagulant properties, reduce the effect of coagulation phenomenon

Active Publication Date: 2018-11-13
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Polymer membrane materials have good chemical stability and are difficult to chemically modify. It is difficult to directly modify the surface of the separation membrane.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 30g of polysulfone, 1500mL of chloroform, stirred until completely dissolved, added 20g of paraformaldehyde (polymerization degree: 20) and 4.5mL of tin tetrachloride, stirred slowly, added dropwise 90mL of chlorosilane ((CH 3 ) 3 CCl), heated to 60°C, reacted for 72h, cooled to room temperature, deposited in an aqueous solution with a volume ratio of ethanol to deionized water equal to 1:1, and dried in vacuum to obtain chloromethylated polysulfone. Take 30g of chloromethylated polysulfone, 40g of tert-butyl acrylate and 3g of copper chloride and dissolve them in 300g of N-methylpyrrolidone. 2 o 3 CH 3 OH, and the precipitate was dried under vacuum at 30 °C. Dissolve 50 g of the dry product in 10% aqueous hydrochloric acid solution, and stir at 100° C. for 48 h to obtain a polyacrylic acid-polysulfone-polyacrylic acid triblock polymer.

[0024] Take polyacrylic acid-polysulfone-polyacrylic acid triblock polymer 15g, polysulfone 25g, polyvinylpyrrolidone 15g and dis...

Embodiment 2

[0029] 30g of polyethersulfone, 1500mL of chloroform, stirred until completely dissolved, added 20g of paraformaldehyde (polymerization degree: 40) and 4.5mL of tin tetrachloride, stirred slowly, added dropwise 90mL of chlorosilane ((CH 3 ) 3 CCl), heated to 60°C, reacted for 72h, cooled to room temperature, deposited in an aqueous solution with a volume ratio of ethanol to deionized water equal to 1:1, and dried in vacuum to obtain chloromethylated polyethersulfone. Take 30g of chloromethylated polyethersulfone, 40g of tert-butyl acrylate and 3g of copper chloride and dissolve them in 300g of N-methylpyrrolidone, blow nitrogen to remove oxygen, react at 80°C for 6h, pass through Al 2 o 3 CH 3OH, and the precipitate was dried under vacuum at 30 °C. Dissolve 50 g of the dried product in 10% aqueous hydrochloric acid solution, and stir at 100° C. for 48 h to obtain a polyacrylic acid-polyethersulfone-polyacrylic acid triblock polymer.

[0030] Take 15g of polyacrylic acid-po...

Embodiment 3

[0035] 35g polysulfone, 1500mL chloroform, stir until completely dissolved, add 20g paraformaldehyde (polymerization degree: 30) and 6.5mL tin tetrachloride, and stir slowly, add 90mL chlorosilane dropwise, heat up to 60°C, react for 72h, cool to room temperature, deposited in an aqueous solution with a volume ratio of ethanol to deionized water equal to 1:1, and dried in vacuum to obtain chloromethylated polysulfone. Take 40g of chloromethylated polysulfone, 50g of tert-butyl acrylate and 3g of copper chloride and dissolve them in 300g of N-methylpyrrolidone. 2 o 3 CH 3 OH, and the precipitate was dried under vacuum at 30 °C. Dissolve 50 g of the dry product in 10% aqueous hydrochloric acid solution, and stir at 100° C. for 48 h to obtain a polyacrylic acid-polysulfone-polyacrylic acid triblock polymer.

[0036] Take 20g of polyacrylic acid-polysulfone-polyacrylic acid triblock polymer, 20g of polyacrylonitrile, 15g of polyethylene glycol and dissolve in 145g of dimethylac...

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PUM

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Abstract

The invention relates to a preparation method of a hemodialysis membrane with high anticoagulant performance, so as to reduce the coagulation phenomenon during the use of the dialysis membrane. The present invention takes the polysulfone hemodialysis membrane as the modification target, first prepares a triblock copolymer containing polysulfone or polyethersulfone and acrylic acid through atom transfer radical polymerization, then blends the copolymer with polysulfone, spins, Preparation of polysulfone hemodialysis membrane. The carboxyl group on the surface of the dialysis membrane is used to graft heparin onto the surface of the dialysis membrane to improve the hydrophilicity and anticoagulant performance of the dialysis membrane. The invention is easy to operate and effectively relieves the coagulation problem during the use of the hemodialysis membrane. The surface hydrophilicity of the prepared hemodialysis membrane is obviously improved, and the anticoagulant ability is obviously improved.

Description

technical field [0001] The invention relates to a method for preparing a hemodialysis membrane with high anticoagulant performance. The method comprises synthesizing a three-block copolymer with a hydrophobic segment and a carboxylic acid group, and co-polymerizing the block copolymer with a membrane-forming polymer. The hemodialysis membrane is prepared by mixing the hemodialysis membrane, and then the active site in the modifier is used to graft heparin on the surface of the membrane to obtain a hemodialyzer with anticoagulant performance. Background technique [0002] Chronic renal failure is a global challenge. As of the end of 2010, 2.621 million patients with chronic renal failure have been treated worldwide, of which about 2.029 million received dialysis treatment in 145 countries, and another 592,000 received kidney transplantation. Among the more than 2 million patients receiving dialysis treatment, about 20% are receiving treatment in the United States, 16% are in ...

Claims

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Application Information

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IPC IPC(8): B01D71/80B01D69/02B01D67/00B01D61/14
Inventor 于海军曹义鸣康国栋刘健辉周美青
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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