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Bio-based hemodialysis membrane and preparation method thereof

A hemodialysis, bio-based technology, applied in dialysis systems, semi-permeable membrane separation, chemical instruments and methods, etc., can solve problems that need to be further improved, achieve no toxic adverse reactions, good biocompatibility, and broad application prospects Effect

Inactive Publication Date: 2016-11-09
林春梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although the existing polylactic acid dialysis membrane has a certain degree of dialysis removal effect, its toughness, high temperature resistance and removal rate still need to be further improved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A bio-based hemodialysis membrane, the hemodialysis membrane is prepared from the following raw materials in parts by weight: 20 parts of polylactic acid, 10 parts of laminarin, 7 parts of thiolated chitosan, 5 parts of silk fibroin, and ascorbyl phosphate 5 parts sodium, 3 parts cellulose acetate, 2 parts dithiothreitol, 5 parts stachyose, 4 parts betulin caffeate, 1 part ammonium persulfate, 1.8 parts ferulic acid, 2 parts hydroxyethyl starch , 2.5 parts of N-benzylglycine hydrochloride, 1 part of deoxycholic acid, 3 parts of polyhydroxyalkanoate, 15 parts of hexamethylenediamine, 4 parts of hyaluronic acid, 1.6 parts of benzoyl peroxide, dimethyl methylene 30 parts of sulfone.

[0023] The preparation method of the above bio-based hemodialysis membrane, the preparation steps are as follows:

[0024] Step 1) Add polylactic acid, laminarin, thiolated chitosan, cellulose acetate and silk fibroin to dimethyl sulfoxide and ethylenediamine, and stir to mix. The temperatur...

Embodiment 2

[0030] A bio-based hemodialysis membrane, the hemodialysis membrane is prepared from the following raw materials in parts by weight: 40 parts of polylactic acid, 19 parts of laminarin, 15 parts of thiolated chitosan, 11 parts of silk fibroin, and ascorbyl phosphate 12 parts sodium, 9 parts cellulose acetate, 6 parts dithiothreitol, 9 parts stachyose, 9 parts betulin caffeate, 3.7 parts ammonium persulfate, 2.5 parts ferulic acid, 4 parts hydroxyethyl starch , 5 parts of N-benzylglycine hydrochloride, 6 parts of deoxycholic acid, 7 parts of polyhydroxyalkanoate, 26 parts of hexamethylenediamine, 8 parts of hyaluronic acid, 3.3 parts of benzoyl peroxide, dimethyl methylene 42 parts of sulfone.

[0031] The preparation method of the above bio-based hemodialysis membrane, the preparation steps are as follows:

[0032] Step 1) Add polylactic acid, laminarin, thiolated chitosan, cellulose acetate and silk fibroin to dimethyl sulfoxide and ethylenediamine, and stir to mix. The mixin...

Embodiment 3

[0038] A bio-based hemodialysis membrane, the hemodialysis membrane is prepared from the following raw materials in parts by weight: 23 parts of polylactic acid, 12 parts of laminarin, 8 parts of thiolated chitosan, 6 parts of silk fibroin, and ascorbyl phosphate Sodium 6 parts, cellulose acetate 3.8 parts, dithiothreitol 2.4 parts, stachyose 5.6 parts, caffeic acid betulin ester 4.1 parts, ammonium persulfate 1.2 parts, ferulic acid 2 parts, hydroxyethyl starch 2.2 parts , 2.6 parts of N-benzylglycine hydrochloride, 2.1 parts of deoxycholic acid, 3.7 parts of polyhydroxyalkanoate, 18 parts of hexamethylenediamine, 4.6 parts of hyaluronic acid, 1.9 parts of benzoyl peroxide, dimethyl methylene 33 parts of sulfone.

[0039] The preparation method of the above bio-based hemodialysis membrane, the preparation steps are as follows:

[0040] Step 1) Add polylactic acid, laminarin, thiolated chitosan, cellulose acetate and silk fibroin to dimethyl sulfoxide and ethylenediamine, sti...

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Abstract

The invention discloses a bio-based hemodialysis membrane and a preparation method thereof. The hemodialysis membrane is prepared from polylactic acid, laminarin, thiolated chitosan, silk fibroin, sodium ascorbyl phosphate, cellulose acetate, dithiothreitol, stachyose, betulin caffeate, ammonium persulfate, ferulic acid, hydroxyethyl starch, N-benzyl glycine hydrochloride, deoxycholic acid, polyhydroxyalkanoate, hexamethylenediamine, hyaluronic acid, benzoperoxide and dimethyl sulfoxide. According to the prepared hemodialysis membrane, the tensile strength is not lower than 7.0 MPa, the transmittance of urea is higher than 86%, the transmittance of beta2 microglobulin is higher than 66%, the rejection rate of macromolecular protein is higher than 95%, the biocompatibility is good, coagulation, thrombus, inflammation, poisoning and other adverse reactions do not exist, and an application prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a bio-based hemodialysis membrane and a preparation method thereof. Background technique [0002] Hemodialysis is to use the principle of semi-permeable membrane to introduce the patient's blood and dialysate into the dialyzer at the same time, flow in reverse on both sides of the dialysis membrane, and remove toxins through diffusion by virtue of the concentration gradient of the solute on both sides of the semi-permeable membrane; Excess water makes the harmful substances in the blood enter the dialysis solution through the dialysis membrane; and the dialyzed blood flows back to the human body to supplement the useful substances needed by the human body to maintain the electrolyte balance and acid-base balance of the blood. Dialysis membrane is an important part in hemodialysis and plays a decisive role in the quality of dialysis. Generally, the ideal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/06B01D67/00A61M1/16
CPCB01D71/06A61M1/16B01D67/0011B01D67/0013B01D2323/50
Inventor 林春梅
Owner 林春梅
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