49results about How to "No inflammation" patented technology

The invention discloses quaternary ammonium salt type hyperbranched polythioether modified polymer microspheres and a preparation method thereof. The preparation method comprises the following steps of: under a photo-initiation condition, taking polyethylene glycol as a pore-foaming agent, taking alkyl dithiol, propargyl glycidyl ether and 1,7-octadiyne as raw materials, and preparing epoxy groupmicroporous polymer spheres by using a sulfydryl-alkyne addition suspension polymerization method; then, under the condition of 0 DEG C, taking methanol as a solvent, and initiating allyl glycidyl ether and a cysteamine compound by ultraviolet light to react to synthesize an [alpha]-epoxy-[omega]-ammonium-based intermediate; and, in a solvent and under the condition of 60 DEG C, synthesizing the hyperbranched ammonium polythioether modified polymer microspheres from the epoxy group microporous polymer spheres, the [alpha]-epoxy-[omega]-ammonium-based intermediate and sodium methoxide in one step. The obtained product has a good killing effect on escherichia coli, and the modified polymer microspheres can be recycled through simple filtration.

The invention discloses a bio-based hemodialysis membrane and a preparation method thereof. The hemodialysis membrane is prepared from polylactic acid, laminarin, thiolated chitosan, silk fibroin, sodium ascorbyl phosphate, cellulose acetate, dithiothreitol, stachyose, betulin caffeate, ammonium persulfate, ferulic acid, hydroxyethyl starch, N-benzyl glycine hydrochloride, deoxycholic acid, polyhydroxyalkanoate, hexamethylenediamine, hyaluronic acid, benzoperoxide and dimethyl sulfoxide. According to the prepared hemodialysis membrane, the tensile strength is not lower than 7.0 MPa, the transmittance of urea is higher than 86%, the transmittance of beta2 microglobulin is higher than 66%, the rejection rate of macromolecular protein is higher than 95%, the biocompatibility is good, coagulation, thrombus, inflammation, poisoning and other adverse reactions do not exist, and an application prospect is wide.

The invention discloses an MOF composite material with an antibacterial function as well as a preparation method and antibacterial application thereof. The preparation method specifically comprises the following steps: adding a mixed DMF solution of 1-hydroxybenzotriazole (HOBT) and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC. HCl) into a DMF dispersion solution of molybdenum disulfide carboxylate (MoS2-COOH) nanoparticles; and stirring for 45 +/-5min under an ice bath condition, adding triethylamine (TEA), uniformly stirring, adding UIO-66-NH2 into the solution, stirring for 13 +/-1h under a room temperature condition, carrying out centrifugal separation after the reaction is finished, discarding the supernatant, collecting the precipitate, cleaning the precipitate, and drying to obtain the functionalized MOF nano-material UIO-66-NH-CO-MoS2. The transition metal sulfide and the MOF are combined through an amido bond, the prepared material not only has the capacity of capturing bacteria, but also has catalase activity and a photothermal conversion effect, the antibacterial effect of the transition metal sulfide and the MOF is optimized, and a very good antibacterial effect is achieved.

The immune response of an animal to a target immunogen may be enhanced by use of a novel adjuvant which includes low concentrations of killed cells of Mycobacterium avium subspecies avium in combination with mineral oil. The adjuvant may be used in vaccine compositions for the immunization of an animal against any target immunogen, and is particularly preferred for use with immunocontraceptive vaccines such as GnRH and PZP immunocontraceptive vaccines.

The invention, belonging to the field of biomedicine, bio-polymer material and magnesium alloy material, relates to a biodegradable magnesium alloy bile duct stone-dissolving carving stent and a preparation method thereof. The stent is prepared by processing magnesium or magnesium alloy into hollow tubes, carving the hollow tubes under the action of laser to a tubular stent with a porous reticular or spiral tubular structure, and then coating a biodegradable polymer layer containing sodium cholate or/and edetate disodium on the inner surface and outer surface of the tubular stent. Clinical outcomes show that the stone-dissolving bile duct stent of the invention has good radial supporting performance, can keep the bile duct open, can be degraded away in a certain time with no need of removing the stent, has good biocompatibility, and lets almost no internal inflammation generate. Simultaneously, sodium cholate or/and edetate disodium slowly released by the polymer layer containing drugs can dissolve the formed stones and can prevent the re-formation of stones.

The invention discloses application of a biologically absorbable polyphosphate and amino acid copolymer to preparation of a repairing material. The polyphosphate and amino acid copolymer is prepared from caprolactam, alpha-amino acid and phosphate, wherein the caprolactam and the alpha-amino acid are firstly polymerized to form a polymer with a multi-component amino acid amide structure; the polymer with the multi-component amino acid amide structure and the phosphate form the polyphosphate and amino acid copolymer. The invention further discloses a blend formed by the polyphosphate and amino acid copolymer and other materials. The polyphosphate and amino acid copolymer is used as the repairing material and has good hydrophilcity and degrading performance, and good mechanical properties; the pH (Potential of Hydrogen) of a degraded product is 6.5 to 7.5 and stimulation reaction is not caused; the polyphosphate and amino acid copolymer has good effect when being used for in-vivo repairing, and can also form the blend with other materials; the polyphosphate and amino acid copolymer has good clinical application prospect.

The invention discloses a biodegradable magnesium alloy braided scaffold for resisting benign and malignant biliary stricture and a preparation method thereof. The braided scaffold is made of magnesium or magnesium alloy, the diameter of a monofilament of the braided scaffold is 0.1 to 2.0 mm, and the braided scaffold has a diameter of 6.0 to 10.0 mm and a length of 6 to 12 mm. The braided scaffold is a pipe with a porous net structure or a helix tube structure braided according to design requirements. The internal surface and the external surface of the braided scaffold are coated with a biodegradable polymer coating containing mitomycin or/and paclitaxel. Since magnesium or magnesium alloy is used as a raw material, the braided scaffold has good radial support performance and can prevent benign and malignant hyperplasia biliary stricture and closure and enables biliary tracts to maintain unobstructed; the braided scaffold is degraded and disappears after a certain period of time and does not need to be taken out again; the braided scaffold has good biocompatibility and does not incur inflammation when acting in vivo; and the polymer coating containing medicines slowly releases mitomycin or/and paclitaxel which can resist benign and malignant hyperplasia biliary stricture, so it is prevented that post-ductular proliferation restenosis after implantation of the scaffold aggravates obstruction of biliary ducts.

The invention discloses Chinese medicinal ointment for treating livestock skin pathological changes and a preparation method thereof. The Chinese medicinal ointment serving as external plasters at least comprises the following medicaments in part by weight: 55 to 65 parts of tung oil, 9 to 11 parts of indigowoad root, 18 to 22 parts of giant knotweed rhizome, 3.6 to 4.4 parts of blackberrykiky rhizome and/or 1.8 to 2.2 parts of vietnamese sophora root, 1.8 to 2.2 parts of figwort root and 1.8 to 2.2 parts of natural indigo, and preferably comprises the following medicaments in part by weight: 60 parts of tung oil, 10 parts of indigowoad root, 20 parts of giant knotweed rhizome, 4 parts of blackberrykiky rhizome, 2 parts of vietnamese sophora root, 2 parts of figwort root and 2 parts of natural indigo. The Chinese medicinal ointment is applied to wounds of livestock continuously for over two days, the livestock can be cured, and particularly, the Chinese medicinal ointment has the obvious curative effect on sore mouth of various degrees.

The invention discloses an annular elastic ring for a medical loop ligation device. The preparation method comprises the following steps: weighing, by mass, 100 parts of medical silicone rubber, 1 to 10 parts of glycerin, 20 to 80 parts of white carbon black and a coupling agent weighing 0 to 2% of the mass of the white carbon black; uniformly mixing the above-mentioned materials on an open mill and putting the obtained mixture in a baking oven for heat treatment; and remilling silicone rubber having undergone heat treatment, adding 0.5 to 5 parts of a cross-linking agent, carrying out uniform mixing, and then successively carrying out hot press molding in a flat vulcanizer and secondary sulfuration in an air blast drying box so as to obtain the annular elastic ring for the medical loop ligation device. The annular elastic ring for the medical loop ligation device overcomes the defect of poor mechanical strength of silicone rubber and provides a nontoxic and harmless annular elastic ring for loop ligation treatment of hemorrhoids. Meanwhile, the annular elastic ring guarantees firm loop ligation, short loop ligation time, a fast tissue shedding speed and no occurrence of infection and inflammations. The preparation method is simple in molding, has low cost and is suitable for large-scale promotion and application.

The invention relates to a biological composite artificial bone and its preparation process. The artificial bone is prepared by poly lactic acid, hydroxyapatite(or calcium phosphate) and OPG protein with weight ratio of 180-250 : 100-160 : 0.6-1. The invention mixes poly lactic acid, hydroxyapatite(or calcium phosphate) and OPG protein only once by emulsion cross blend method without changing their chemical structure. The adopted ethyl acetate and absolute ethyl alcohol have no harm to the human body, and the hydroxyapatite(or calcium phosphate) bone conduction function and the osteoclast genesis and activation of the OPG protein are kept. It can also initiate osteoclast apoptosis. The compound product is a biological compound artificial bone for treating bone defection and osteoporosis in clinical practice.

The invention discloses a preparation method of water-soluble carboxymethyl chitosan, belonging to the technical field of carboxymethyl chitosan preparation. The present invention takes dried poria cocos and heats it in a deionized water bath, filters the filtrate to obtain the rotary evaporation, then adds chloroacetic acid for ultrasonic oscillation and rotary evaporation to prepare modified crystals for later use, then takes chitosan and isopropanol shaking table for oscillation treatment, and mixes with alkali The solution is mixed in a water bath and heated, mixed with the spare modified crystal in a water bath, acid is added for neutralization, and the supernatant is obtained by centrifugation, and the water-soluble carboxymethyl chitosan obtained is obtained through rotary evaporation, washing and drying. The beneficial effects of the present invention are: the preparation steps of the present invention are simple, the bulk density of the obtained product is as high as 0.46-0.56g/mL, the fluidity is good, the degree of substitution is high, and the water-solubility is good; Water-soluble carboxymethyl chitosan is obtained, which effectively solves the problem of product antibacterial activity and moisture retention performance reduction.

The invention discloses a preparation method of a biologically absorbable polyphosphate and amino acid copolymer material. The preparation method comprises the following steps: 1) dehydrating alpha-amino acid and caprolactam under the protection of inert gas at 150 DEG C to 200 DEG C; 2) reacting at 190 DEG C to 260 DEG C and finishing polymerization reaction to form a polymer with a multi-component amino acid amide structure; 3) adding phosphate and reacting at 200 DEG C to 260 DEG C for 0.5h to 2h and finishing ring-opening copolymerization reaction; cooling to room temperature under the protection of the inert gas to obtain a product. A polyphosphate and amino acid copolymer prepared by the method has good hydrophilcity and degrading performance, and good mechanical properties; the pH (Potential of Hydrogen) of a degraded product is 6.5 to 7.5 and stimulation reaction is not caused; the polyphosphate and amino acid copolymer has good effect when being used for in-vivo repairing and has good clinical application prospect.

The invention relates to a universal desktop support for laptops and tablet computers, which belongs to computer accessories. One end of a laptop supporting plate is movably connected with a door-shaped frame, the other end of the laptop supporting plate is connected with one end of each of a left T-shaped supporting plate, a right T-shaped supporting plate, a left supporting rod and a right supporting rod through a damping shaft, a screw which can be used for adjusting the length of each supporting rod is embedded in a non-connecting end of each supporting rod, limit clamps are inserted onto the T-shaped supporting plates, a through groove is arranged in the middle of the laptop supporting plate, and a long screw is arranged in the middle of the through groove and provided with a laptop limit clamp. According to the sitting height of a user, the rise range of the laptop supporting plate can be adjusted, so that the center of a laptop screen can be flush with eyes of the user, the user can use the laptop when keeping upright sitting posture, and health potential threats to the neck and the waist of the user caused by the fact that the laptop screen is too low are thoroughly eliminated. Further, the user can easily input information with an external keyboard when wrists are relaxed by the aid of a palm supporting plate.