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MOF composite material with antibacterial function as well as preparation method and application thereof

A composite, functional technology, used in pharmaceutical formulations, bandages, surgery, etc., to solve problems such as lack of interaction, reduced bactericidal activity, short lifespan and diffusion distance

Active Publication Date: 2021-05-14
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, MoS 2 The lack of effective interaction with bacteria, and the inherent short lifetime and diffusion distance of ROS greatly reduce their bactericidal activity

Method used

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  • MOF composite material with antibacterial function as well as preparation method and application thereof
  • MOF composite material with antibacterial function as well as preparation method and application thereof
  • MOF composite material with antibacterial function as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1, UIO-66-NH-CO-MoS 2 Preparation of Nanomaterials

[0037] 50mg MoS 2-COOH nanoparticles were uniformly dispersed in 25mL DMF, which was recorded as the dispersion ①; then 287.55mg HOBT and 202.65mg EDC·HCl were dissolved in 1.5mL DMF, which was recorded as the solution ②; then the solution ② was added to the dispersion ①, and the After stirring for 45 min in ice bath, 1 mL of TEA was added, and after stirring evenly, 60 mg of UIO-66-NH 2 Added to the above mixed system, stirred at room temperature for 12h. After the reaction, centrifuge (9000r / min) for 6min, discard the supernatant, wash the collected product 3 times with DMF, wash 3 times with absolute ethanol, and obtain the nanomaterial UIO-66-NH-CO after vacuum drying -MoS 2 . 101.5 mg of the nanomaterial product was obtained, with a yield of 92.3% and a purity of about 91%.

Embodiment 2

[0038] Example 2, UIO-66-NH-CO-MoS 2 Characterization of Nanomaterials

[0039] (1) Electron microscope analysis (SEM, TEM) and energy dispersive spectrometer (EDS) elemental analysis

[0040] Scanning electron microscopy (JSM7500F) and transmission electron microscopy (JEM2100) were used to analyze the UIO-66-NH-CO-MoS prepared in Example 1 2 Nanomaterials were observed and analyzed for their morphology, and the results are shown in the attached figure 1 :

[0041] figure 1 a is UIO-66-NH 2 SEM photos of the morphology, it can be observed that UIO-66-NH 2 octahedral crystallite structure. figure 1 b is MoS 2 SEM photos of the morphology, it can be observed that MoS 2 similar spherical microcrystalline structure. figure 1 c is UIO-66-NH-CO-MoS 2 The transmission scanning electron micrograph of UIO-66-NH can be observed 2 with MoS 2 linked by chemical bonds. figure 1 d is UIO-66-NH-CO-MoS 2 The elemental analysis shows the existence of the corresponding key elemen...

Embodiment 3

[0048] Example 3, UIO-66-NH-CO-MoS 2 Antibacterial experiment of nanomaterials

[0049] 1) Preparation of primary seed liquid: take 100 μL each of Staphylococcus aureus (ATCC 6538) and Escherichia coli (ATCC 8739) frozen in the laboratory, respectively, in 100 mL LB liquid medium (Haibo Biological), and shake at constant temperature for 13 hours (37°C, 100rpm) to obtain the primary seed solution;

[0050] 2) Preparation of the secondary seed liquid: 100 μL of the primary seed liquid obtained in 1) was respectively transferred to a new 100 mL LB liquid medium to obtain the secondary seed liquid;

[0051] 3) Preparation of antibacterial mother solution: Weigh an appropriate amount of UIO-66-NH 2 、MoS 2 、H 2 o 2 、MoS 2 +H 2 o 2 、UIO-66-NH-CO-MoS 2 and UIO-66-NH-CO-MoS 2 +H 2 o 2 Add respectively in the secondary seed liquid obtained in 2), the material concentration is 20 μ g / mL, H 2 o 2 The concentration is 2mmol / L, after irradiating with 808nm laser lamp (0.5W) fo...

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Abstract

The invention discloses an MOF composite material with an antibacterial function as well as a preparation method and antibacterial application thereof. The preparation method specifically comprises the following steps: adding a mixed DMF solution of 1-hydroxybenzotriazole (HOBT) and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC. HCl) into a DMF dispersion solution of molybdenum disulfide carboxylate (MoS2-COOH) nanoparticles; and stirring for 45 + / -5min under an ice bath condition, adding triethylamine (TEA), uniformly stirring, adding UIO-66-NH2 into the solution, stirring for 13 + / -1h under a room temperature condition, carrying out centrifugal separation after the reaction is finished, discarding the supernatant, collecting the precipitate, cleaning the precipitate, and drying to obtain the functionalized MOF nano-material UIO-66-NH-CO-MoS2. The transition metal sulfide and the MOF are combined through an amido bond, the prepared material not only has the capacity of capturing bacteria, but also has catalase activity and a photothermal conversion effect, the antibacterial effect of the transition metal sulfide and the MOF is optimized, and a very good antibacterial effect is achieved.

Description

technical field [0001] The invention relates to the technical field of antibacterial nanomaterials, in particular to bonding MoS through chemical bonds 2 With MOF material UIO-66-NH-CO-MoS 2 Preparation and its application in antibacterial products. Background technique [0002] Bacterial infectious diseases are one of the world's largest health problems. Due to the overuse of antibiotics, a large number of drug-resistant bacteria and superbugs have developed. For more than two decades, a great deal of effort in related fields has been dedicated to discovering new drugs, making new materials, and exploring new avenues to address the problems posed by antibiotic resistance. Metal-organic frameworks (MOFs) are one of the multifunctional porous materials constructed by metals and organic ligands, which have the advantages of large specific surface area, good thermal and chemical stability, good flexibility, convenient synthesis, and high tunability. It has been recognized a...

Claims

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Application Information

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IPC IPC(8): C08L87/00C08K9/04C08K3/30A61L26/00A61L31/02A61L31/16
CPCC08K9/04C08K3/30A61L31/028A61L31/16A61L26/0004A61L26/0066A61L26/008A61L2300/404A61L2300/102A61L2300/412A61L2400/12C08K2003/3009C08K2201/011C08L87/00
Inventor 高巍伟夏亚穆廖姿杨王涛李明哲左嘉敏邵宁宁
Owner QINGDAO UNIV OF SCI & TECH
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