Biodegradable magnesium alloy carved support capable of preventing bile duct benign and malignant stricture and manufacture method thereof

Abstract

The invention discloses a biodegradable magnesium alloy carved support capable of preventing bile duct benign and malignant stricture and a manufacture method thereof. The biodegradable magnesium alloy carved support comprises a hollow pipe made of magnesium or a magnesium alloy. The inner diameter of the hollow pipe is 5.5-10 mm, the outer diameter of the hollow pipe is 6.4-10.5 mm, and the length of the hollow pipe is 6-12 cm. The hollow pipe is a pipe of a porous net-shaped structure or a spiral pipe structure and is carved under laser according to a design requirement. A biodegradable polymer layer containing mitomycin or / and paclitaxel is coated on the inner surface and the outer surface of the hollow pipe. Due to the fact that the support is made of magnesium or the magnesium alloy, the radial supporting performance is good, stricture and closing caused by bile duct hyperplasia can be prevented, and a bile duct is kept smooth. The biodegradable magnesium alloy carved support can be degraded and vanished within certain time, is not required to be taken out again, is good in biocompatibility, and almost causes no inflammation during working in vivo. The mitomycin or / and paclitaxel released by the polymer coating layer containing medicine can prevent bile duct benign and malignant hyperplasia stricture, and bile duct obstruction aggravated by stricture generated again by hyperplasia after the support is implanted is prevented.

Description

technical field [0001] The invention belongs to the field of biomedicine, and the field of biopolymer materials and magnesium alloy materials, and in particular relates to a biodegradable magnesium alloy engraved stent for resisting benign and malignant bile duct strictures and a preparation method thereof. Background technique [0002] Pancreaticobiliary malignant tumors with pancreaticobiliary obstruction are common clinical diseases with a high incidence rate. They have insidious onset, and most of them are late-stage when they are discovered. It shows that about 60-70% of patients have lost the chance of radical surgery when they are diagnosed; some patients can only take non-surgical palliative treatment due to old age and infirmity or other serious diseases of other organs. However, the current palliative treatment methods are mainly to relieve pancreaticobiliary duct obstruction and ensure drainage. They include: systemic or transvascular interventional chemotherapy, ...

AI Technical Summary

Problems solved by technology

[0002] Pancreaticobiliary malignant tumors with pancreaticobiliary obstruction are common clinical diseases with a high incidence rate. They have insidious onset, and most of them are late-stage when they are discovered. About 60-70% of patients have lost the chance of radical surgery when they are diagnosed; some patients can only take non-surgical palliative treatment due to old age and infirmity or complicated diseases of other organs

However, the current palliative treatment methods are mainly to relieve pancreaticobiliary duct obstruction and ensure drainage. They include: systemic or transvascular interventional chemotherapy, radiotherapy, surgical transabdominal cholangioenteric or pancreaticojejunostomy, etc., but the side effects are too large; therefore, currently used Endoscopic pancreaticobiliary stent placement and drainage

[0003] The defect of the existing pancreaticobiliary stents is that although these stents can improve the drainage, they cannot control the development of the tumor, and often re-stenosis occurs due to the continuous proliferation of the tumor. The condition deteriorates rapidly; in addition, many stents are difficult to remove when pancreaticobiliary restenosis occurs, mainly due to the hyperplasia of stimulated tissue or significant tumor tissue hyperplasia at the site where the stent is placed, and are tightly fitted with the stent, aggravating the stenosis

According to the corrosion resistance of magnesium and magnesium alloys, it has good application prospects in biomedical degradable implant materials and devices, such as bone nails, bone plates for internal fixation, and magnesium alloy cardiovascular stents. Application not reported