62results about How to "Conformationally stable" patented technology

The invention provides a pitavastatin calcium enteric sustained-release micropill preparation and a preparation method thereof, which can solve the problems that: (1) pitavastatin calcium is easily subjected to inversion of configuration under the condition that gastric juice has a low pH value, and has low stability, and (2) common tablets are released too quickly, so that active ingredients cannot fully achieve the effect of reducing cholesterol in the prior art. The technical scheme is that: the pitavastatin calcium enteric sustained-release micropill preparation comprises a medicine-containing pill core, an isolation layer, a sustained-release layer and an enteric layer from inside to outside, wherein the medicine-containing pill core comprises pitavastatin calcium and pharmaceutical excipients. The invention also provides a preparation method for the micropill preparation. The prepared micropill is not released in the gastric juice, and medicines are prevented from being exposed in the acid environment; by adopting microporous film coating technology, the medicines can be slowly released from the pill core, the blood concentration is kept balanced, the medicine taking frequency is reduced and the compliance of the patient is improved.

The invention discloses a deformable wheel-track composite walking mechanism. The deformable wheel-track composite walking mechanism comprises a deformable wheel-track main frame used for enabling the outer contour to be transformed between a flat and long octagon and a quasi-circular shape; a track, wherein the outer edge of the deformable wheel track main frame is coated with the track, and the shape of the track can be changed under the driving of the deformable wheel track main frame; a track driving device which is arranged at the middle position in the deformable wheel-track main frame and is used for driving the crawler belt to rotate; a wheel-track main frame driving device which is arranged in the middle of the outer surface of the deformable wheel-track main frame and used for driving the deformable wheel-track main frame to turn over. According to the deformable wheel-track main frame, based on the multi-connecting-rod movement principle, the driving triangular wheel sets are driven by the deformation driving devices to slide in the corresponding groove holes of the limiting plates, then the triangular wheel sliding wheels and the longitudinal adjusting wheels are driven, and the deformable wheel-track main frame is converted between the quasi-circular configuration and the flat and long configuration; the maneuvering performance and the passing performance of the platform walking mechanism are enhanced, and maintenance and repair are easy.

The invention provides a preparation method of alvimopan and an intermediate for synthesizing the alvimopan. The preparation method comprises the following steps of: designing a process route through a two-chain method, respectively synthesizing initial raw materials, then condensing and hydrolyzing to obtain the alvimopan. The method can be used for directionally synthesizing a single optical isomer through N-alkylation reaction under an alkaline condition, the configuration change of the chiral centers of the raw materials and the product can not be generated both in reaction conditions and a post-processing method, and the obtained product can be hydrolyzed into the alvimopan under the mild alkaline condition.

The invention relates to the technical field of a molecular thin film and a manufacturing method of the molecular thin film, and discloses a molecular thin film coated on an optical lens. The molecular thin film contains the n-octadecyl trichlorosilane and an antibacterial drug, wherein the weight ratio of the antibacterial drug to the n-octadecyl trichlorosilane is 3-13. The invention further discloses a manufacturing method of the molecular thin film, the method comprises the following steps of: a preposed step of preparing a matrix, the n-octadecyl trichlorosilane and an antibacterial drug in advance; a cleaning step of cleaning the oil and the pollutant on the surface of the matrix; and a soaking step of soaking the matrix in a mixture to form a molecular thin film on the surface of the matrix, wherein the mixture is composed of the n-octadecyl trichlorosilane and the antibacterial drug. The molecular thin film not only can resist pollution and avoid adhering of outside dust and smudginess, but also can effectively resist the pollution of normal bacterial flora and fungus flora in the environment, thereby improving the light transmission and prolonging the service life of the optical lens.

The invention discloses a moon cake. The moon cake comprises a moon cake cladding and a moon cake filling, wherein the moon cake cladding comprises the following raw materials: 40 to 70 percent of wheat flour, 20 to 45 percent of sugar alcohol, 2 to 8 percent of L-arabinose, 5 to 20 percent of animal and vegetable oil or hydrogenated animal and vegetable oil and 0.2 to 2 percent of alkaline water. The technical problems of soft cladding and poor plasticity caused by the low viscosity of a sugar-free moon cake which takes maltitol solution as a cladding in the prior art are solved. Therefore, the moon cake has the characteristics of easily-shaped cladding, high plasticity and stable texture in baking process.

The invention discloses a satellite cluster control method based on the artificial potential field method including dynamic avoidance and damping characteristics, including: taking the main satellite as the center, dividing its communication area, using different artificial potential fields in different areas, so as to maintain The configuration of the satellite cluster is stable; according to the relative position and relative velocity of the members in the satellite cluster, an artificial potential field method controller including dynamic avoidance is designed centered on each member satellite to ensure that the member satellites in the cluster do not occur during the mission. Collision: In view of the increase in the demand for space missions and the fact that the number of existing satellites is not enough to complete the mission, an artificial potential field method controller including damping characteristics is designed, which can effectively ensure that newly added satellites can safely and reliably join the current cluster, Form a new cluster. This method is suitable for satellite cluster configuration maintenance, collision avoidance, and cluster reorganization under space perturbation conditions.