wound dressing sheet

A covering material and wound technology, applied in the field of wound covering sheets of natural or regenerated cellulose fibers, can solve the problems of inability to be used for wound healing, increased strength, poor liquid absorption, etc., and achieve the effect of promoting wound healing

Active Publication Date: 2021-02-02
ASAHI KASEI KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The strength of CMC-H is increased, but there is a problem that the liquid absorption is at the same level as that of ordinary cellulose nonwoven fabrics
On the other hand, in the following Patent Document 3, partially protonated CMC is used as an anti-adhesion material, but it has poor liquid absorption and cannot be used for wound healing.

Method used

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Examples

Experimental program
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Embodiment

[0072] Hereinafter, the present invention will be specifically described using examples, but the present invention is not limited to these examples.

reference example 1

[0074] Regenerated cellulose continuous long fiber sheet structure (cupro fiber sheet structure) (width 20cm, weight per unit area 80g / m 2 , thickness 0.5mm, density 0.154g / m 3 ), lyocell staple fiber nonwoven fabric, or rayon staple fiber nonwoven fabric 100g was put into the reaction container, and then, after adding sodium hydroxide-containing ethanol aqueous solution (water: 875g, ethanol 875g, NaOH: 162.5g) , stirred at 35 °C for 30 min. Next, after the reagent in the reaction vessel was discharged, an aqueous ethanol solution (300 g of water, 960 g of ethanol, and 122.5 g of sodium monochloroacetate) containing sodium monochloroacetate was added, and stirred at 30° C. or 50° C. for 1 to 12 hours. Then, it was dried to obtain a carboxymethylated sheet-like structure. The sheet-like structure obtained above was adjusted to pH 6.0 to 8.0 with an aqueous ethanol solution containing acetic acid (acetic acid: 37.5 g, distilled water: 375 g, ethanol: 875 g), washed once with ...

reference example 2

[0079] Slices (2 cm×1 cm) were cut out from the pre-protonated CMC sheet-like structure (substitution degree 0.55) obtained by the method of Reference Example 1, and 10 slices were placed in 50 mL plastic tubes. 30 mL of an aqueous methanol solution containing hydrochloric acid (1.2 mol / L hydrochloric acid, 90% methanol) was added to each tube, and incubated at room temperature for 10 minutes, 30 minutes, and 1 hour.

[0080] After incubation, it was washed sequentially with 80% aqueous methanol and 100% methanol, and dried to obtain a protonated sheet-like structure. The data of the degree of protonation are shown in Table 2 below together with the protonation conditions.

[0081] [Table 2]

[0082]

[0083] It was found that almost 100% of the substituents were protonated at the concentration of hydrochloric acid in Reference Example 2.

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Abstract

The present invention provides a novel wound dressing sheet having high liquid absorbency and strength. The wound dressing sheet of the present invention is characterized in that it is a wound dressing material containing carboxymethylated natural or regenerated cellulose fibers, and the average substitution degree of hydroxyl groups in glucose units constituting the cellulose is 0.3 or more and 1.0 or less. , and not less than 5% and not more than 80% of the carboxymethyl groups are protonated.

Description

technical field [0001] The present invention relates to a wound dressing sheet comprising natural or regenerated cellulose fibers comprising partially protonated carboxymethylcellulose (hereinafter abbreviated as CMC). More specifically, the present invention relates to a wound dressing sheet containing natural or regenerated cellulose fibers containing CMC capable of maintaining high liquid absorption and maintaining shape stability even after liquid absorption. Background technique [0002] When a wound occurs on the human skin or the like, wound site protection materials such as surgical dressings and wound dressing materials that protect the site of the wound are used. [0003] On the other hand, the following Patent Document 1 describes a soluble wound-hemostatic cellulose fiber having a CMC substitution degree of 0.5 to less than 1.0, and also describes that CMC has a cell adhesion promoting action. In addition, the following Patent Document 2 also describes that when...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61F13/00C08B11/12
CPCA61L15/28C08B11/12A61F13/00012C08L1/26A61F13/00042C08L5/14
Inventor 原雄一
Owner ASAHI KASEI KK
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