The invention provides an atmospheric and vacuum distillation device and an atmospheric and vacuum distillation method of high acid-content crude oil. The device comprises an atmospheric tower, an atmospheric kiln, a vacuum tower and a vacuum kiln, wherein the atmospheric tower comprises a tower body, a tower tray and stuffing. The tower tray of the atmospheric tower has more than 40 layers, wherein the tower body of the atmospheric tower between the 40th layer of the tower tray and the tower top is made of metallic composite of one or a plurality of Monel, 0Cr13, 316L, SAF2205, SAF2507 and SAF 2304 and carbon steel, the tower tray is made of one or a plurality of Monel, 0Cr13, 316L, SAF2205, SAF2507 and SAF 2304, the tower body of the atmospheric tower between the tower bottom and the 40th layer of the tower tray is made of metallic composite of 316 L and carbon steel, the tower trays from the 28th layer to the 39th layer are made of 0Cr13 material and the tower trays from the first layer to the 28th layer are made of 316L. The atmospheric and vacuum distillation device effectively solves the problem of device corrosion in the atmospheric and vacuum distillation of high acid-content crude oil.