The invention relates to a gasoline hydrodesulfurization method, which comprises the following steps that: gasoline raw materials are fractionated into light fraction gasoline and heavy fraction gasoline, wherein the light fraction gasoline is removed mercaptan sulfer through caustic washing refining, the heavy fraction gasoline carries out a hydrogenation diene-removal reaction, a selective hydrodesulfurization reaction and a selective hydrogenation mercaptan sulfer-removal reaction respectively through two hydrogenation reactors, and the obtained hydrogenation heavy fraction gasoline and the refined light fraction gasoline are mixed to obtain full fraction gasoline with ultra-low sulfur. According to the method provided by the invention, under the condition that the desulfurization degree reaches a target, the full fraction gasoline product have small mercaptan sulfur content, less olefin saturation and small octane value loss. The mercaptan sulfur content of the obtained dull fraction gasoline product is less than 10Mug/g, the total sulfur content is reduced under 50Mug/g, and the octane value RON loss is less than 1.0 unit, particularly, the total sulfur content of the full fraction gasoline product is reduced under 10 Mug/g, and the octane value RON loss is less than 1.5 units.