The invention discloses a process for treating mine wastewater containing sulfur minerals, As, Pb and Cd, which comprises the following steps: (1) performing blast aeration and oxidation treatment on the mine wastewater containing the sulfur minerals, As, Pb and Cd in an aeration tank; (2) neutralizing and coagulating the wastewater after the aeration and oxidation in a neutralization tank and controlling the pH to be between 8.6 and 9.5; (3) standing and depositing the wastewater after the neutralization and the coagulation treatment in a sedimentation tank; and (4) after the wastewater is clear after standing for a certain period of time, performing advanced treatment on heavy metal in a supernatant in a physical and chemical adsorption device and an activated carbon filtering system to obtain clean water meeting the environmental-protection or agricultural requirement. Through the process, peculiar smell in the mine wastewater can be eliminated, the wastewater color is changed to be normal, and the requirement of the quality of mine wastewater containing the discharged sulfur minerals, As, Pb and Cd in 'Standards for irrigation water quality' (GB5084-2005) can be met.