Biodegradable magnesium alloy braided scaffold for resisting benign and malignant biliary stricture and preparation method thereof

Abstract

The invention discloses a biodegradable magnesium alloy braided scaffold for resisting benign and malignant biliary stricture and a preparation method thereof. The braided scaffold is made of magnesium or magnesium alloy, the diameter of a monofilament of the braided scaffold is 0.1 to 2.0 mm, and the braided scaffold has a diameter of 6.0 to 10.0 mm and a length of 6 to 12 mm. The braided scaffold is a pipe with a porous net structure or a helix tube structure braided according to design requirements. The internal surface and the external surface of the braided scaffold are coated with a biodegradable polymer coating containing mitomycin or/and paclitaxel. Since magnesium or magnesium alloy is used as a raw material, the braided scaffold has good radial support performance and can prevent benign and malignant hyperplasia biliary stricture and closure and enables biliary tracts to maintain unobstructed; the braided scaffold is degraded and disappears after a certain period of time and does not need to be taken out again; the braided scaffold has good biocompatibility and does not incur inflammation when acting in vivo; and the polymer coating containing medicines slowly releases mitomycin or/and paclitaxel which can resist benign and malignant hyperplasia biliary stricture, so it is prevented that post-ductular proliferation restenosis after implantation of the scaffold aggravates obstruction of biliary ducts.

Description

technical field [0001] The invention belongs to the field of biomedicine, the field of biopolymer materials and magnesium alloy materials, and in particular relates to a biodegradable magnesium alloy braided stent for resisting benign and malignant bile duct strictures and a preparation method thereof. Background technique [0002] Pancreaticobiliary malignant tumors with pancreaticobiliary obstruction are common clinical diseases with a high incidence rate. They have insidious onset, and most of them are late-stage when they are discovered. It shows that about 60-70% of patients have lost the chance of radical surgery when they are diagnosed; some patients can only take non-surgical palliative treatment due to old age and infirmity or other serious diseases of other organs. However, the current palliative treatment methods are mainly to relieve pancreaticobiliary duct obstruction and ensure drainage. They include: systemic or transvascular interventional chemotherapy, radio...

AI Technical Summary

Problems solved by technology

[0002] Pancreaticobiliary malignant tumors with pancreaticobiliary obstruction are common clinical diseases with a high incidence rate. They have insidious onset, and most of them are late-stage when they are discovered. About 60-70% of patients have lost the chance of radical surgery when they are diagnosed; some patients can only take non-surgical palliative treatment due to old age and infirmity or complicated diseases of other organs

However, the current palliative treatment methods are mainly to relieve pancreaticobiliary duct obstruction and ensure drainage. They include: systemic or transvascular interventional chemotherapy, radiotherapy, surgical transabdominal cholangioenteric or pancreaticojejunostomy, etc., but the side effects are too large; therefore, currently used Endoscopic pancreaticobiliary stent placement and drainage

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