Alginate fiber hematodialysis membrane and preparation method thereof

A seaweed fiber, hemodialysis technology, applied in semipermeable membrane separation, chemical instruments and methods, membrane technology, etc. High strength and good biocompatibility

Inactive Publication Date: 2015-03-25
SUZHOU COSMETIC MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] According to the above-mentioned disclosed technical solutions, the hemodialysis membrane is a polysulfone membrane. In order to improve the hemodialysis membrane, a biocompatible functional polymer is added to the hemodialysis membrane to reduce the complement activation effect, but the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A seaweed fiber hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, comprising the following components in parts by mass: 20 parts of polyamide, 10 parts of seaweed fiber, 3 parts of polyvinyl acetate toughening agent, 5 parts of polylactic acid, acetone 15 copies and DMAC 15 copies.

[0022] A preparation method of seaweed fiber hemodialysis membrane adopts dry-wet method preparation process, and the preparation steps are as follows:

[0023] (1) To prepare the spinning solution, mix the components together, stir evenly and then filter to remove impurities, and place it in the spinning solution tank for vacuum defoaming for 35 hours;

[0024] (2) Water is used as the core fluid and coagulation bath, the core hydraulic pressure is 0.01MPa, and the temperature of the coagulation bath is kept at 25°C;

[0025] (3) Adjust the pressure of the spinning solution tank to 0.3MPa, the temperature to 43°C, the temperature of the spinneret (0.1 / 0.2 mm) to 37°...

Embodiment 2

[0029] A seaweed fiber hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, comprising the following components in parts by mass: 35 parts of polyamide, 20 parts of seaweed fiber, 8 parts of polyvinyl alcohol toughening agent, 15 parts of polylactic acid, acetone 20 copies and DMAC 40 copies;

[0030] A preparation method of seaweed fiber hemodialysis membrane adopts dry-wet method preparation process, and the preparation steps are as follows:

[0031] (1) To prepare the spinning solution, mix the components together, stir evenly and then filter to remove impurities, and place it in the spinning solution tank for vacuum defoaming for 35 hours;

[0032] (2) Water is used as the core fluid and coagulation bath, the core hydraulic pressure is 0.02MPa, and the temperature of the coagulation bath is kept at 25°C;

[0033] (3) Adjust the pressure of the spinning liquid tank to 0.4MPa, the temperature to 40°C, the temperature of the spinneret (0.2 / 0.3 mm) to 37°C...

Embodiment 3

[0037] A seaweed fiber hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, comprising the following components in parts by mass: 27 parts of polyamide, 16 parts of seaweed fiber, 5 parts of polysulfone, 12 parts of polylactic acid, 20 parts of acetone and DMAC 25 copies;

[0038] A preparation method of seaweed fiber hemodialysis membrane adopts dry-wet method preparation process, and the preparation steps are as follows:

[0039] (1) To prepare the spinning solution, mix the components together, stir evenly and then filter to remove impurities, and place it in the spinning solution tank for vacuum defoaming for 35 hours;

[0040] (2) Water is used as the core fluid and coagulation bath, the core hydraulic pressure is 0.04MPa, and the temperature of the coagulation bath is kept at 25°C;

[0041] (3) Adjust the pressure of the spinning liquid tank to 0.7MPa, the temperature to 37°C, the temperature of the spinneret (0.1 / 0.3 mm) to 37°C, set the rotating sp...

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Abstract

The invention provides an alginate fiber hematodialysis membrane and a preparation method thereof, relating to the field of biological materials. The alginate fiber hematodialysis membrane is a hollow fiber membrane and comprises the following components in parts by weight: 20-35 parts of polyamide, 10-20 parts of alginate fiber, 3-8 parts of a toughening agent, 5-15 parts of polylactic acid and 30-60 parts of a solvent, wherein the average inner diameters of hollow fibers are 100-300 microns, and the wall thicknesses of the hollow fibers are 20-50 microns. According to the preparation method of the alginate fiber hematodialysis membrane, the alginate fiber hematodialysis membrane is prepared by virtue of a dry-wet method preparation process. According to the alginate fiber hematodialysis membrane, the hollow fiber membrane with good biocompatibility and high mechanical strength is prepared by virtue of the characteristic of high biocompatibility of the alginate fiber and the superiorities of the dry-wet method preparation process. By adjusting parameters in the dry-wet method preparation process, particularly the pressures of core liquid and a spinning solution tank, the prepared hollow fiber has large inner diameter and small wall thickness and is beneficial to the elimination of micromolecule toxin and the entrapment of macromolecule protein.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a seaweed fiber hemodialysis membrane and a preparation method of the hemodialysis membrane. Background technique [0002] The hemodialysis membrane uses the principle of a semi-permeable membrane to introduce the patient's blood and dialysate into the dialyzer at the same time. The two flow in opposite directions on both sides of the dialysis membrane. , in order to achieve the purpose of removing toxins and excessive water retention in the body, replenishing the substances needed in the body, and maintaining electrolyte and acid-base balance. A dialyzer mainly consists of a support structure and a dialysis membrane. According to the support structure, the shape of the membrane and the mutual configuration relationship, the dialyzers that have appeared successively in history can basically be divided into three types: flat plate type, coil type and hollow fiber type. Among ...

Claims

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Application Information

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IPC IPC(8): B01D71/56B01D67/00B01D69/08
Inventor 陈晋纳欧阳智琨喻国贞
Owner SUZHOU COSMETIC MATERIALS
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