Method for preparing amino acid modified polyether sulfone hematodialysis membrane

Abstract

The invention relates to the technology of hematodialysis membranes, and aims at providing a method for preparing an amino acid modified polyether sulfone hematodialysis membrane. The method comprises the steps that chloromethyl group polyether sulfone, polarity aprotic organic solvent and a micromolecule pore-forming agent are taken and mixed to be stirred and dissolved to obtain a uniform and stable membrane casting solution; vacuum standing and bubble removing are carried out, and a chloromethyl group polyether sulfone hollow fiber membrane is prepared through a dry / wet phase inversion method and then immersed in hot water; finally, immersing is carried out through an ethanol solution, and drying is carried out; the chloromethyl group polyether membrane is immersed in a sodium hydroxide water solution to be reacted; the chloromethyl group polyether membrane is immersed in hot water; finally, the chloromethyl group polyether membrane is immersed in the ethanol solution, drying is carried out, and then the product is obtained. The chloromethyl group polyether sulfone hollow fiber membrane serves as a precursor material, and precise and controllable amidogen acidification modification can be carried out on the chloromethyl group polyether sulfone membrane through the electrophilic substitution policy. The polyether sulfone hematodialysis membrane modified through amino acid has the advantages of permanent hydrophilia, low-protein adsorbability and superior biocompatibility.

Description

technical field [0001] The invention relates to hemodialysis membrane technology, in particular to a method for preparing an amino acid modified polyethersulfone hollow fiber membrane with low protein adsorption and excellent biocompatibility. Background technique [0002] Hemodialysis uses the principle of a semi-permeable membrane to introduce the patient's blood and dialysate into the dialyzer at the same time, flow in reverse on both sides of the dialysis membrane, and remove toxins through diffusion by virtue of the concentration gradient of solutes on both sides of the semi-permeable membrane. Eliminate excess water in the body through osmosis, so that harmful substances in the blood can enter the dialysate through the dialysis membrane. The dialyzed blood then flows back into the human body to supplement the useful substances needed by the human body and maintain the electrolyte balance and acid-base balance of the blood. It can be seen that the dialysis membrane is ...

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Problems solved by technology

However, since the inorganic nanoparticles and the polyethersulfone membrane, especially the membrane surface, are only a simple physical adsorption, there is a major hidden danger of falling off the membrane surface during subsequent use.

[0004] Through the investigation of the above-mentioned prior art, it can be found that a relatively large disadvantage is that for the modification method of improving the performance of polyethersulfone membrane by blending, whether it is adding a hydrophilic macromolecular polymer or having a nanoscale The inorganic nanoparticles in the future applications may be gradually released from the polyethersulfone membrane, thus causing many problems in the application of drinking water, food, especially in the field of medicine; Therefore, in the process of membrane preparation, it will also bring greater difficulty to the regulation of membrane pore structure.

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