Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Polyacrylonitrile/cellulose acetate fiber composite hemodialysis membrane and preparation method thereof

A technology of acetate fiber and polyacrylonitrile, applied in the direction of semi-permeable membrane separation, chemical instruments and methods, membrane technology, etc., can solve the problem of unsatisfactory removal of small molecule toxins, and achieve the reduction of anaphylactic toxins, low cost, and biological good compatibility

Inactive Publication Date: 2015-02-25
SUZHOU COSMETIC MATERIALS
View PDF5 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] It can be seen that the fiber membrane is a hollow fiber formed by the synthetic first polymer and the optional hydrophilic second polymer, which has a good sieving coefficient for albumin and cytochrome, but for small molecule toxins The removal is not ideal

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A polyacrylonitrile / cellulose acetate composite hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, including the following components in parts by mass: 35 parts of polyacrylonitrile fiber, 25 parts of acetate fiber, 3 parts of KH560 coupling agent, acetone 10 copies and DMAC 25 copies.

[0024] According to the preparation method provided by the present invention, the polyacrylonitrile / cellulose acetate composite hemodialysis membrane is prepared, and the dry-wet method is adopted. The preparation steps are as follows:

[0025] (1) Prepare the spinning solution, add polyacrylonitrile fiber and acetate fiber to the solvent, mix evenly, add coupling agent, and stir until uniform at a temperature of 45°C;

[0026] (2) Put the spinning solution into the spinning solution tank, vacuum defoaming, time 36h;

[0027] (3) Water is used as the core fluid, and the core hydraulic pressure is 0.02MPa; DMSO is used as the coagulation bath, the concentration of ...

Embodiment 2

[0032] A polyacrylonitrile / cellulose acetate composite hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, including the following components in parts by mass: 60 parts of polyacrylonitrile fiber, 40 parts of acetate fiber, 7 parts of KH560 coupling agent, acetone 20 copies and DMAC 40 copies.

[0033] According to the preparation method provided by the present invention, the polyacrylonitrile / cellulose acetate composite hemodialysis membrane is prepared, and the dry-wet method is adopted. The preparation steps are as follows:

[0034] (1) Prepare the spinning solution, add polyacrylonitrile fiber and acetate fiber to the solvent, mix evenly, add coupling agent, and stir until uniform at a temperature of 50°C;

[0035] (2) Put the spinning solution into the spinning solution tank, vacuum defoaming, time 36h;

[0036] (3) Water is used as the core fluid, and the core hydraulic pressure is 0.02MPa; DMSO is used as the coagulation bath, the concentration of ...

Embodiment 3

[0041] A polyacrylonitrile / cellulose acetate composite hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, including the following components in parts by mass: 47 parts of polyacrylonitrile fiber, 31 parts of acetate fiber, 5 parts of KH560 coupling agent, acetone 18 parts and 36 parts in DMSO.

[0042] According to the preparation method provided by the present invention, the polyacrylonitrile / cellulose acetate composite hemodialysis membrane is prepared, and the dry-wet method is adopted. The preparation steps are as follows:

[0043](1) Prepare the spinning solution, add polyacrylonitrile fiber and acetate fiber to the solvent, mix evenly, add coupling agent, and stir until uniform at a temperature of 55°C;

[0044] (2) Put the spinning solution into the spinning solution tank, vacuum defoaming, time 36h;

[0045] (3) Water is used as the core fluid, and the core hydraulic pressure is 0.03MPa; DMSO is used as the coagulation bath, the concentration of ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Average inner diameteraaaaaaaaaa
Wall thicknessaaaaaaaaaa
Tensile strengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a polyacrylonitrile / cellulose acetate fiber composite hemodialysis membrane and a preparation method thereof, and relates to the field of biological materials. The hemodialysis membrane refers to a hollow fiber membrane, the average inner diameter of hollow fibers is 122-245 microns, and the wall thickness is 22-50 microns. The hemodialysis membrane comprises the following components in parts by mass: 35-60 parts of polyacrylonitrile fibers, 25-40 parts of cellulose acetate fibers, 3-7 parts of a coupling agent and 30-60 parts of solvents, wherein the solvents refer to acetone and DMAC or acetone and DMSO. In the method for preparing the polyacrylonitrile / cellulose acetate fiber composite hemodialysis membrane, a dry-wet preparation process is adopted. The polyacrylonitrile / cellulose acetate fiber composite hemodialysis membrane provided by the invention is relatively high in retention rate of bovine serum albumin, relatively high in biocompatibility, relatively high in permeability on vitamin B12 and relatively low in cost and is a relatively ideal hemodialysis membrane material.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a polyacrylonitrile / cellulose acetate composite hemodialysis membrane and a preparation method of the hemodialysis membrane. Background technique [0002] Hemodialysis membrane uses the principle of semi-permeable membrane, with the help of the solute gradient, osmotic gradient and water pressure gradient on both sides of the membrane, to remove toxins and retain excess water in the body, and at the same time replenish the substances needed in the body, and maintain electrolytes and purpose of acid-base balance. Existing dialysis membranes are mainly hollow fiber dialysis membranes, which are divided into two categories: cellulose acetate and synthetic materials according to different membrane materials. According to the affinity of the membrane for water, it is divided into hydrophobicity and hydrophilicity, and hydrophilicity is generally used. [0003] Polyacrylonitrile (...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): B01D71/42B01D69/08B01D67/00A61M1/18
Inventor 欧阳智琨喻国贞张帆
Owner SUZHOU COSMETIC MATERIALS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com