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Citric acid-chitosan-modified anticoagulation polyurethane blood dialysis membrane and preparation method thereof

A chitosan modification, hemodialysis technology, applied in chemical instruments and methods, dialysis systems, peritoneal dialysis and other directions, can solve problems such as insufficient hemodialysis membrane, achieve excellent blood compatibility, good stability, and preparation method Simple and easy to control effects

Inactive Publication Date: 2015-08-19
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the deficiencies in blood compatibility of existing hemodialysis membranes

Method used

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  • Citric acid-chitosan-modified anticoagulation polyurethane blood dialysis membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add 16% of the above-mentioned anticoagulant modified polyurethane and 84% solvent (both are composed of mass percentage), add it to the raw material tank, heat and stir at 95°C for 2 hours, and after fully dissolving, let it stand for 8 hours at a temperature of 25°C Degassing to obtain a uniform membrane liquid; open the nitrogen valve to maintain the pressure of the raw material tank at about 0.06MPa, the membrane liquid is filtered and sent to the spinning head through a metering pump, the flow rate of the membrane liquid is 1.10mL / min, The core fluid is passed through, and the flow rate of the core fluid is 1.07mL / min. Under the traction of the wire winding machine, the nascent hollow fiber membrane enters the coagulation bath after passing through the 2cm air distance. The temperature of the coagulation bath is 30 ℃, and the cleaning bath is 30 ℃. On the silk machine, the winding speed is 50m / min. The prepared modified polyurethane hemodialysis membrane has an in...

Embodiment 2

[0026] Add 18% of the above-mentioned anticoagulant modified polyurethane and 82% solvent (both are composed of mass percentage), add it to the raw material tank, heat and stir at 90°C to dissolve for 2.5 hours, and after fully dissolving, let it stand at a temperature of 25°C for 8 hours Degassing to obtain a uniform membrane liquid; open the nitrogen valve to maintain the pressure of the raw material tank at about 0.08MPa, the membrane liquid is filtered and sent to the spinning head through a metering pump, the flow rate of the membrane liquid is 1.10mL / min, The core fluid was passed through, and the flow rate of the core fluid was 1.08mL / min. Under the traction of the wire winding machine, the nascent hollow fiber membrane enters the coagulation bath after passing through the 4cm air distance. The temperature of the coagulation bath is 26°C. On the silk machine, the winding speed is 45m / min. The prepared modified polyurethane hemodialysis membrane has an inner diameter of...

Embodiment 3

[0028] Add 24% of the above-mentioned anticoagulant modified polyurethane and 76% of solvent (both are composed of mass percentage), add it to the raw material tank, heat and stir at 85°C to dissolve for 3 hours, and after fully dissolving, let it stand at a temperature of 30°C for 10 hours Degassing to obtain a uniform membrane liquid; open the nitrogen valve to maintain the pressure of the raw material tank at about 0.10MPa, the membrane liquid is filtered and sent to the spinning head through a metering pump, the flow rate of the membrane liquid is 1.35mL / min, The core fluid is passed through, and the flow rate of the core fluid is 1.39mL / min. Under the traction of the winding machine, the nascent hollow fiber membrane enters the coagulation bath after passing through an air distance of 8cm. The temperature of the coagulation bath is 15°C. After the cleaning bath, the cleaning bath is 20°C. On the silk machine, the winding speed is 40m / min. The prepared modified polyuretha...

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Abstract

The invention discloses a citric acid-chitosan-modified anticoagulation polyurethane blood dialysis membrane and a preparation method thereof. The membrane is of a hollow fibrous structure, and the inner surface and outer surface are dense cortical layers, and the middle is a porous supporting layer, so that the blood dialysis membrane is high in permeability and separating property and antibacterial property; the inner diameter is 160 to 250mu m; the membrane thickness is 30 to 50 mu m, and the ultrafiltration coefficient is 7.0 to 60 ml / m<2>.h.mmHg; citric acid-chitosan-modified anticoagulation polyurethane is taken as membrane materials, and in membrane solution, the percentage mass content of the modified anticoagulation polyurethane is 15 to 30%, and the percentage mass content of a solvent is 70 to 85%, and the blood dialysis membrane is prepared by using a nonsolvent induced phase separation method. The preparation process of the dialysis membrane is simple and easy to control, and the prepared membrane has good anticoagulant activity, biocompatibility and antibacterial property, and the clearance rates of urea, beta2-microglobulin and albumin are respectively 55 to 80%, 48 to 60%, and 2.5 to 9%, and the rate of resisting pathogenic escherichia coli is 99%.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to an anticoagulant polyurethane hemodialysis membrane modified by citric acid and chitosan and a preparation method thereof. Background technique [0002] Polyurethane has good biocompatibility and physical properties, and is one of the commonly used dialysis membrane materials. However, when it is in direct contact with blood, it is easily contaminated by blood protein, and because of its insufficient anticoagulant performance, contact with blood can also lead to the formation of thrombus. The invention is dedicated to solving the deficiencies of the existing polyurethane hemodialysis membrane in anticoagulation, and provides an anticoagulant modified polyurethane hemodialysis membrane and a preparation method thereof. [0003] There have been many research reports on hemodialysis membranes. For example, Chinese patent CN 103316596 A discloses a method for preparing an antico...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/02B01D67/00B01D69/08B01D71/54A61M1/28
Inventor 邱运仁徐静远吴兴泽
Owner CENT SOUTH UNIV
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