Polyester anticoagulation blood dialysis membrane and preparation method thereof

A hemodialysis and anticoagulation technology, applied in the field of medical equipment, can solve the problems of inability to perform dialysis, high risk of damage, blood coagulation, etc., to reduce the risk of blood coagulation, improve dialysis efficiency, and improve the effect of retention rate

Inactive Publication Date: 2018-02-27
广州青岭医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, the anticoagulant property of the hemodialysis membrane is not high, and it is easy to cause blood coagulation. Once the coagulation will cause a chain reaction, resulting in the impossibility of dialysis, the existing dialysis membrane has poor flexibility, and the risk of damage during the dialysis process is relatively high. , and the retention rate of small protein molecules in the existing dialysis membrane is poor

Method used

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  • Polyester anticoagulation blood dialysis membrane and preparation method thereof

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Embodiment 1

[0023] The invention provides a technical solution: a polyester anticoagulant hemodialysis membrane, the dialysis membrane is mainly made of polyester material, contains 10 parts of polyester material, 5 parts of polysulfone, and 4 parts of polymethyl methacrylate , 6 parts of protein fiber, 15 parts of protein mixed material, 5 parts of peptidoglycan, 3 parts of glycerin, and 8 parts of anticoagulant.

[0024] Wherein, the polyester material comprises 4 parts of cellulose acetate and 10 parts of polyacrylonitrile. The polysulfone comprises 1 part of polyarylsulfone and 4 parts of polyethersulfone. The protein mixture material comprises 5 parts of silk protein and 10 parts of collagen. The protein fiber is casein fiber. The anticoagulant contains 3 parts of heparin and 5 parts of hirudin.

[0025] A method for preparing the above-mentioned polyester anticoagulant hemodialysis membrane, comprising the following steps:

[0026] S1: Add polyester material, polysulfone, polyme...

Embodiment 2

[0031] The invention provides a technical solution: a polyester anticoagulant hemodialysis membrane, the dialysis membrane is mainly made of polyester material, containing 21 parts of polyester material, 7 parts of polysulfone, and 6 parts of polymethyl methacrylate , 8 parts of protein fiber, 18 parts of protein mixed material, 7 parts of peptidoglycan, 5 parts of glycerin, and 12 parts of anticoagulant.

[0032] Wherein, the polyester material comprises 6 parts of cellulose acetate and 13 parts of polyacrylonitrile. The polysulfone comprises 2 parts of polyarylsulfone and 5 parts of polyethersulfone. The protein mixture material contains 7 parts of silk protein and 11 parts of collagen. The protein fiber is casein fiber. The anticoagulant contains 4 parts of heparin and 8 parts of hirudin.

[0033] A method for preparing the above-mentioned polyester anticoagulant hemodialysis membrane, comprising the following steps:

[0034] S1: Add polyester materials, polysulfone, po...

Embodiment 3

[0039] The invention provides a technical solution: a polyester anticoagulant hemodialysis membrane, the dialysis membrane is mainly made of polyester material, containing 24 parts of polyester material, 9 parts of polysulfone, and 9 parts of polymethyl methacrylate , 9 parts of protein fiber, 20 parts of protein mixed material, 9 parts of peptidoglycan, 8 parts of glycerin, and 15 parts of anticoagulant.

[0040] Wherein, the polyester material comprises 8 parts of cellulose acetate and 15 parts of polyacrylonitrile. The polysulfone comprises 3 parts of polyarylsulfone and 6 parts of polyethersulfone. The protein mixture material contains 8 parts of silk protein and 12 parts of collagen. The protein fiber is casein fiber. The anticoagulant contains 5 parts of heparin and 10 parts of hirudin.

[0041] A method for preparing the above-mentioned polyester anticoagulant hemodialysis membrane, comprising the following steps:

[0042] S1: Add polyester materials, polysulfone, p...

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Abstract

The invention discloses a polyester anticoagulation blood dialysis membrane. The dialysis membrane takes a polyester material as a main body. The polyester anticoagulation blood dialysis membrane is prepared from 10 to 24 parts of polyester material, 5 to 9 parts of polysulfone, 4 to 9 parts of polymethyl methacrylate, 6 to 9 parts of protein fiber, 15 to 20 parts of protein mixed material, 5 to 9parts of peptidoglycan, 3 to 8 parts of glycerol and 8 to 15 parts of anticoagulant. The invention further discloses a preparation method of the polyester anticoagulation blood dialysis membrane. Thepreparation method comprises the following steps: S1, mixing silk making materials; S2, removing air bubbles; S3, mixing the anticoagulant; S4, spinning. The polyester anticoagulation blood dialysismembrane has the advantages of good anticoagulation effect, higher flexibility and high retention rate of micromolecular proteins.

Description

technical field [0001] The invention relates to the field of medical equipment, in particular to a polyester anticoagulant hemodialysis membrane and a preparation method thereof. Background technique [0002] Hemodialysis (HD) is one of the renal replacement therapies for patients with acute and chronic renal failure. It drains the blood from the body to the outside of the body through a dialyzer composed of countless hollow fibers, and the blood and the electrolyte solution (dialysate) with a similar concentration to the body are exchanged through diffusion / convection inside and outside the hollow fibers , remove metabolic waste from the body, maintain electrolyte and acid-base balance; remove excess water from the body at the same time, and return the purified blood to the entire process called hemodialysis. [0003] Dialysis membrane is a separation membrane driven by concentration difference. According to the particle size of the separated solute, the dialysis membrane...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/42B01D71/16B01D67/00
CPCB01D67/0002B01D71/16B01D71/42
Inventor 章青
Owner 广州青岭医疗器械有限公司
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