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Nanometer magnetic hemodialysis membrane and preparation method thereof

A nano-magnetic, hemodialysis technology, applied in semi-permeable membrane separation, chemical instruments and methods, membrane technology, etc., can solve the problems of blood protein pollution, platelet aggregation, etc.

Inactive Publication Date: 2015-03-25
SUZHOU COSMETIC MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantage is that the surface of the membrane is easily polluted by blood protein after long-term use, and long-term contact will also lead to platelet aggregation. Therefore, it is necessary to modify polymethyl methacrylate or add other materials to prolong its service life.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A nano-magnetic hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, comprising the following components in parts by mass: 25 parts of polymethyl methacrylate, polyethylene glycol modified nano-Fe 3 o 4 6 parts of particles, 5 parts of polyacrylamide and 24 parts of solvent, the solvent is acetone and DMAC, the mass ratio of the two is 0.5:1.

[0025] According to the preparation method provided by the present invention, the nano-magnetic hemodialysis membrane is prepared, and the dry-wet method is adopted, and the preparation steps are as follows:

[0026] (1) Prepare the spinning solution, put each component into the spinning solution tank and mix evenly, after vacuum defoaming, preheat to 35°C;

[0027] (2) Use deionized water as the core fluid, and adjust the core hydraulic pressure to 0.01MPa;

[0028] (3) Use DMSO as the coagulation bath, the concentration of DMSO in the coagulation bath is 65%, and the temperature is 55°C;

[0029] (4) Adju...

Embodiment 2

[0033] A nano-magnetic hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, comprising the following components in parts by mass: 30 parts of polymethyl methacrylate, albumin modified nano-Fe 3 o 4 7 parts of particles, 5 parts of polyacrylamide and 29 parts of solvent, the solvent is acetone and DMAC, the mass ratio of the two is 2:3.

[0034] According to the preparation method provided by the present invention, the nano-magnetic hemodialysis membrane is prepared, and the dry-wet method is adopted, and the preparation steps are as follows:

[0035] (1) Prepare the spinning solution, put each component into the spinning solution tank and mix evenly, after vacuum defoaming, preheat to 35°C;

[0036] (2) Use deionized water as the core fluid, and adjust the core hydraulic pressure to 0.01MPa;

[0037] (3) Use DMSO as the coagulation bath, the concentration of DMSO in the coagulation bath is 65%, and the temperature is 55°C;

[0038] (4) Adjust the spinnin...

Embodiment 3

[0042] A nano-magnetic hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, comprising the following components in parts by mass: 35 parts of polymethyl methacrylate, starch-modified superparamagnetic nano-Fe 3 o 4 9 parts of particles, 10 parts of polyacrylamide and 34 parts of solvent, the solvent is acetone and DMAC, the mass ratio of the two is 2:3.

[0043] According to the preparation method provided by the present invention, the nano-magnetic hemodialysis membrane is prepared, and the dry-wet method is adopted, and the preparation steps are as follows:

[0044] (1) Prepare the spinning solution, put each component into the spinning solution tank and mix evenly, after vacuum defoaming, preheat to 50°C;

[0045] (2) Use deionized water as the core fluid, and adjust the core hydraulic pressure to 0.04MPa;

[0046] (3) Use DMSO as the coagulation bath, the concentration of DMSO in the coagulation bath is 75%, and the temperature is 65°C;

[0047] (4) Ad...

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Abstract

The invention provides a nanometer magnetic hemodialysis membrane and a preparation method thereof, and the nanometer magnetic hemodialysis membrane relates to the field of biological materials. The nanometer magnetic hemodialysis membrane comprises the following components in parts by weight: 25-40 parts of polymethyl methacrylate, 6-12 parts of polymer modified magnetic nanoparticles, 5-15 parts of polyacrylamide and 24-45 parts of a solvent, wherein the dialysis membrane is a hollow fiber membrane, the average inside diameter is 155-245 microns, the wall thickness is 32-45 microns, the solvent is acetone and DMAC, and the mass ratio of the acetone to the DMAC is (0.5-1):1. The preparation method of the nanometer magnetic hemodialysis membrane adopts a wet and dry method preparation process. The nanometer magnetic hemodialysis membrane provided by the invention can effectively provide biocompatibility and protein adsorption resistance to effectively reduce blood protein adsorption resulting from long-term use, and has high water ultrafiltration performance and small molecule dialysis transmittance, thus being a hemodialysis membrane material with excellent application prospect.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a nanometer magnetic hemodialysis membrane and a preparation method of the hemodialysis membrane. Background technique [0002] Hemodialysis membrane uses the principle of semi-permeable membrane, with the help of the solute gradient, osmotic gradient and water pressure gradient on both sides of the membrane, to remove toxins and retain excess water in the body, and at the same time replenish the substances needed in the body, and maintain electrolytes and purpose of acid-base balance. [0003] Polymethyl methacrylate is also a commonly used hemodialysis membrane material. It has good hydrophilicity, and is characterized by high permeability to urea and small molecular substances, and good film-forming elasticity. However, the disadvantage is that the surface of the membrane is easily polluted by blood protein after long-term use, and long-term contact will also lead to plate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/40B01D67/00B01D69/02B01D69/08
Inventor 全春兰金仲恩陈晋纳
Owner SUZHOU COSMETIC MATERIALS
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