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Method for preparing efficient blood coagulation resistant biomaterial with aqueous solution and corresponding material

A biomaterial and aqueous solution technology, applied in anticoagulant blood treatment, transportation and packaging, packaging item types, etc., can solve the problems of unfavorable biomaterial biocompatibility, difficulty in removing organic solvents, and inability to guarantee anticoagulant drugs, etc., to achieve Good blood compatibility, blood compatibility, simple and easy modification process

Active Publication Date: 2020-02-07
HUNAN PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reaction process of this method is complicated, and it cannot guarantee that active substances such as anticoagulant drugs are only expressed on the surface of biological materials, and the waste of drugs is serious; and organic solvents are often used as solvents many times during the reaction process, and it is difficult to completely remove organic solvents, and organic solvents enter the human body It is not conducive to the health of patients, and it is also not conducive to the improvement of biocompatibility of biomaterials

Method used

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  • Method for preparing efficient blood coagulation resistant biomaterial with aqueous solution and corresponding material
  • Method for preparing efficient blood coagulation resistant biomaterial with aqueous solution and corresponding material
  • Method for preparing efficient blood coagulation resistant biomaterial with aqueous solution and corresponding material

Examples

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Effect test

Embodiment 1

[0044] The method for preparing highly effective anticoagulant biomaterials using an aqueous solution in the present embodiment adopts the following steps:

[0045] ①Weigh 0.6g tris hydroxymethylaminomethane and completely dissolve it in 50ml pure water, then add 0.6ml 20% HCl hydrochloric acid solution to prepare an aqueous solution with pH=8.5 for later use.

[0046] ②Weigh 3g of polyethersulfone raw material and 0.5g of polyethylene glycol, dissolve the two in 13.2g of dimethyl sulfoxide (DMSO), and stir magnetically for 48 hours at room temperature to prepare 18wt.% homogeneous transparent poly Ethersulfone film casting solution, let it stand for 48 hours to defoam, then scrape the polyethersulfone flat film in pure water at 4°C according to the liquid-liquid phase conversion method, soak it in pure water, wash it, and dry it for later use;

[0047] ③ Weigh 10 mg of argatroban and 50 mg of dopamine hydrochloride, and dissolve them in 50 ml of the pH 8.5 aqueous solution pr...

Embodiment 2

[0050] In the present embodiment, the method for preparing an efficient anticoagulant biomaterial using an aqueous solution adopts the following steps:

[0051] ①Weigh 0.6g tris hydroxymethylaminomethane and completely dissolve it in 50ml pure water, then add 0.6ml 20% HCl hydrochloric acid solution to prepare an aqueous solution with pH=8.5 for later use.

[0052] ②Weigh 3g of polyethersulfone raw material and 0.5g of polyethylene glycol, dissolve the two in 13.2g of dimethyl sulfoxide (DMSO), and stir magnetically for 48 hours at room temperature to prepare 18wt.% homogeneous transparent poly Ethersulfone film casting solution, let it stand for 48 hours to defoam, then scrape the polyethersulfone flat film in pure water at 4°C according to the liquid-liquid phase conversion method, soak it in pure water, wash it, and dry it for later use;

[0053] ③ Weigh 50 mg of argatroban and add it to 10 ml of ethanol to completely dissolve the argatroban, add 50 mg of argatroban ethanol...

Embodiment 3

[0056] In the present embodiment, the method for preparing an efficient anticoagulant biomaterial using an aqueous solution adopts the following steps:

[0057] ①Weigh 0.6g tris hydroxymethylaminomethane and completely dissolve it in 50ml pure water, then add 0.6ml 20% HCl hydrochloric acid solution to prepare an aqueous solution with pH=8.5 for later use.

[0058] ②Weigh 3g of polyethersulfone raw material and 0.5g of polyethylene glycol, dissolve the two in 13.2g of dimethyl sulfoxide (DMSO), and stir magnetically for 48 hours at room temperature to prepare 18wt.% homogeneous transparent poly Ethersulfone film casting solution, let it stand for 48 hours to defoam, then scrape the polyethersulfone flat film in pure water at 4°C according to the liquid-liquid phase conversion method, soak it in pure water, wash it, and dry it for later use;

[0059] ③ Weigh 300 mg of argatroban and add it to 30 ml of ethanol to completely dissolve the argatroban, add 100 mg of dopamine hydroch...

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Abstract

The invention discloses a method for preparing an efficient blood coagulation resistant biomaterial with an aqueous solution. The aqueous solution has a self-assembly characteristic, is high in biochemistry activity, can form hydrogen bonds with anticoagulation / antithrombus medicines, and has the characteristic of being firmly attached to the biomaterial, so that the surface of the biomaterial (such as a blood purification film, a blood purification pipeline, a cardiovascular stent and an artificial blood vessel) has anticoagulation / antithrombus activity. The surface modification process disclosed by the invention is simple in experimental condition, high in controllability, economical and environment-friendly; and the aqueous solution is high in shaping properties, so that the aqueous solution is basically suitable for anticoagulation / antithrombus modification of the surface of the biomaterial in any shape. The dopamine hydrochloride aqueous solution is prepared, a micromolecule anticoagulant medicine-argatroban is grafted to the surface of a haemodialysis film, the haemodialysis film having anticoagulation / antithrombus activity is successfully prepared, the usage of a whole bodyanticoagulant is reduced or avoided, and the bleeding risk of a haemodialysis patient is reduced.

Description

technical field [0001] The invention relates to a preparation method of a biological material with anticoagulant performance, which belongs to the surface modification technology of the biological material which needs to be in contact with blood. Background technique [0002] With the advancement of medical technology, biomaterials (blood purification filters, blood purification circulation lines, cardiovascular and cerebrovascular stents, etc.) The complement system, etc., lead to the formation of thrombus on the surface of biomaterials, which restricts their clinical efficacy. In order to solve the problem of thrombus formation on the surface of biomaterials, the currently widely used clinical solutions are systemic anticoagulation (heparin, low molecular weight heparin, warfarin, dabigatran, etc.), antiplatelet / antithrombotic (aspirin, chloride, etc.) Pidogrel) drugs, but systemic use of these drugs will affect the systemic coagulation system of patients and increase the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L33/04A61L33/00A61L31/10A61L31/08A61L31/16
CPCA61L31/08A61L31/10A61L31/16A61L33/0041A61L33/04A61L2300/204A61L2300/42C08L79/02
Inventor 付双双刘可黄坚梁玉梅宁建平徐晓平欧阳沙西凌文涛杨伊雅
Owner HUNAN PROVINCIAL PEOPLES HOSPITAL
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