Highly blood coagulation resistant cellulose membrane material and preparation method thereof

A cellulose membrane and blood coagulation technology, applied in the field of cellulose membrane materials with good hemocompatibility and its preparation, can solve the problems of biological toxicity, heparin activity limitation, etc., and achieve easy operation, good biocompatibility, and reduce defects Effect

Inactive Publication Date: 2009-05-13
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the further research, its inherent defects are gradually revealed: the heparin in the coating will be slowly dissolved from the coating and used up, but the activity of the heparin immobilized on the surface is limited; Oxygen or an environment with transition metal ions degrades and causes certain biological toxicity, etc.

Method used

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  • Highly blood coagulation resistant cellulose membrane material and preparation method thereof
  • Highly blood coagulation resistant cellulose membrane material and preparation method thereof
  • Highly blood coagulation resistant cellulose membrane material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Add 25ml of 0.05mol / L triethylamine tetrahydrofuran solution to the reactor containing 10 diaphragms pretreated by tetrahydrofuran, and then add the initiator 2-bromoisobutylacyl bromide according to the ratio of the amount of substance M 三甲胺 :M 2-溴代异丁基酰溴 = 1.2:1 into the reactor. After continuing the reaction for 1 hour, the membrane was taken out, washed with chloroform and ethanol in sequence, and then dried in vacuum. Then put the film with the initiator fixed on the surface into the methanol degassed solution of 0.1mol / L ammonium phosphate zwitterionic monomer (R is methacrylate type), and then pass into nitrogen protection, and then CuCl and di Pyridine according to the ratio of the amount of substance M 两性离子 :M CuCl :M 联二吡啶 =2:1:1 added to the reaction system. Stir the reaction at room temperature for 16 hours, take out the membrane, wash it with PBS buffer solution and water in sequence, and dry it in vacuum.

Embodiment 2

[0042] Add 20mL of 0.5mol / L trimethylamine tetrahydrofuran solution to the reactor containing 10 diaphragms pretreated by acetone, and then add 2-bromoisobutylacyl bromide according to the ratio of the amount of substance M 三甲胺 :M 2-溴代异丁基酰溴 = 1.8:1 into the reactor. After continuing the reaction for 8 hours, the membrane was taken out, washed with dichloromethane and ethanol in sequence, and then dried in vacuum. Then put the film with the initiator fixed on the surface into the methanol degassed solution of 1mol / L sulfonamide zwitterionic monomer (R is methacrylate amine ester type), then pass into nitrogen protection, and then CuBr and pentamethyl Diethylenetriamine according to the ratio of the amount of substance M 两性离子 :M CuBr :M 五甲基二亚乙基三胺 =4:1:1 added to the reaction system. Stir and react at room temperature for 1 hour, take out the membrane, wash with ethanol and water in sequence, and dry in vacuum to obtain a highly anticoagulant cellulose membrane material.

Embodiment 3

[0044] Add 50mL of 1mol / L triethylamine tetrahydrofuran solution to the reactor containing 20 membranes pretreated by tetrahydrofuran, and then dichloroacetyl chloride according to the ratio of the amount of substance M 三甲胺 :M 二氯乙酰氯= 1.2:1 into the reactor. After continuing the reaction for 1 hour, the membrane was taken out, washed with chloroform and ethanol in sequence, and then dried in vacuum. Then put the film with the initiator fixed on the surface into the methanol degassed solution of 0.1mol / L sulfonamide zwitterionic monomer (R is styrene type), then pass into nitrogen protection, and then CuBr and pentamethyldisulfide Ethyltriamine according to the ratio of the amount of substance M 两性离子 :M CuBr :M 五甲基二亚乙基三胺 =10:1:1 was added to the reaction system. Stir and react at room temperature for 24 hours, take out the membrane, wash with PBS buffer solution and water in sequence, and dry in vacuum to obtain a highly anticoagulant cellulose membrane material.

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Abstract

The invention relates to a highly ticoagulant cellulose membrane material, wherein an amphichroic ionomer layer is grafted on the surface of a cellulose membrane, and a 'brush'-shaped amphichroic ionomer layer is formed on the surface of the cellulose membrane. The cellulose membrane with good biocompatibility is prepared by grafting of amphichroic ionic molecules on the surface of the material. The neat 'brush'-shaped amphichroic ionomer layer is formed on the surface of cellulose, so that the defects on the surface of the material are overcome, and the action between the material and biomacromolecules is further reduced, thereby nonspecific protein absorption and blood platelet adhesion are reduced to the maximum degree. Therefore, the cellulose membrane material has high nonspecific protein absorption resistance and high ticoagulant performance. The invention discloses a method for manufacturing the highly ticoagulant cellulose membrane material.

Description

technical field [0001] The invention relates to a blood-compatible material and a preparation method thereof, in particular to a cellulose membrane material with good blood compatibility and a preparation method thereof. Background technique [0002] Cellulose membrane (Cellulose Membrane) is widely used in biomedical fields such as tissue engineering, controlled release, blood purification and purification because of its good mechanical properties and potential biocompatibility. However, its biocompatibility, especially hemocompatibility, is not enough for the application. [0003] In recent years, in order to improve the biocompatibility of cellulose membrane, especially good blood compatibility, there are a lot of reports on the surface modification of cellulose at home and abroad. For example, materials with good blood compatibility such as heparin (Heparin), polyethylene glycol (PEG) and other materials with good blood compatibility are fixed or grafted to the surface ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/16C08L1/02
Inventor 沈健陈强刘平生林思聪
Owner NANJING UNIV
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