Acrylic acid and sulfonated dihydroxypropyl chitosan modified polysulfone membrane and preparation method thereof

A technology of sulfonated dihydroxypropyl chitosan and branched sulfonated dihydroxypropyl shell, which is applied in the field of biomedical materials, can solve problems such as blood coagulation and protein adsorption, achieve improved hydrophilicity, simple preparation method, and maintain Effect of Mechanical Strength and Structural Stability

Active Publication Date: 2019-02-12
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention aims to solve the problems of protein adsorption and blood coagulation when polysulfone materials are used, and provides a modified polysulfone membrane with good blood compatibility and its preparation method

Method used

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  • Acrylic acid and sulfonated dihydroxypropyl chitosan modified polysulfone membrane and preparation method thereof
  • Acrylic acid and sulfonated dihydroxypropyl chitosan modified polysulfone membrane and preparation method thereof
  • Acrylic acid and sulfonated dihydroxypropyl chitosan modified polysulfone membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Add the polysulfone membrane (PSF membrane) to a mass concentration of 2% acrylic acid (AA) aqueous solution for 30 minutes; take out the polysulfone membrane or leave it in the original solution, and continue to irradiate it under a 160W ultraviolet lamp for 5 minutes. After taking it out, wash it with absolute ethanol and Wash with deionized water and dry in vacuum at 50°C to obtain AA-PSF membrane;

[0038] Add the above-mentioned AA-PSF membrane to 4°C, acetic acid buffer solution with a carbodiimide (EDC) concentration of 3mmoL / L for 4h to activate the carboxyl groups on the surface of the membrane; then wash with phosphate buffer and deionized water in sequence, Then add the activated membrane to 4°C, 0.1mg / mL SDHPCS acetic acid solution, stir for 20h; soak the obtained membrane in 2mmoL / L glutaraldehyde solution at 30°C for 60min, and then wash it with phosphate buffer saline Wash with deionized water, soak in deionized water for 12 hours, and dry in vacuum at re...

Embodiment 2

[0040] The polysulfone membrane (PSF membrane) was added to a mass concentration of 2% acrylic acid (AA) aqueous solution for 30 minutes; the polysulfone membrane was taken out or left in the original solution, and continuously irradiated under a 180W ultraviolet lamp for 10 minutes, and after taking it out, it was washed with absolute ethanol and Wash with deionized water and dry in vacuum at 50°C to obtain AA-PSF membrane;

[0041]Add the above-mentioned AA-PSF membrane to 4 ℃, acetic acid buffer solution with a carbodiimide (EDC) concentration of 3mmoL / L for 4h to activate the carboxyl groups on the surface of the membrane; then wash with phosphate buffer and deionized water in sequence, Then add the activated membrane to acetic acid solution of 0.2mg / mL SDHPCS at 4°C, and stir for 20h; soak the obtained membrane in 2mmoL / L glutaraldehyde solution at 30°C for 60min, and then rinse with phosphate buffer saline Wash with deionized water, soak in deionized water for 12 hours, ...

Embodiment 3

[0043] Add the polysulfone membrane (PSF membrane) into the aqueous solution of 3% acrylic acid (AA) for 30 minutes; take out the polysulfone membrane or leave it in the original solution, and continuously irradiate it under a 200W ultraviolet lamp for 8 minutes. Washed with deionized water and dried under vacuum at 50°C to obtain AA-PSF membrane;

[0044] Add the above-mentioned AA-PSF membrane to 4 ℃, acetic acid buffer solution with a carbodiimide (EDC) concentration of 3mmoL / L for 4h to activate the carboxyl groups on the surface of the membrane; then wash with phosphate buffer and deionized water in sequence, Then add the activated membrane to acetic acid solution of 0.2mg / mL SDHPCS at 4°C, and stir for 20h; soak the obtained membrane in 2mmoL / L glutaraldehyde solution at 30°C for 60min, and then rinse with phosphate buffer saline Wash with deionized water, soak in deionized water for 12 hours, and dry in vacuum at regular temperature to obtain SDHPCS-AA-PSF membrane.

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Abstract

The invention discloses an acrylic acid and sulfonated dihydroxypropyl chitosan modified polysulfone membrane and a preparation method thereof. The preparation method comprises the following steps: grafting acrylic acid (AA) on the surface of a polysulfone membrane (PSF membrane) through ultraviolet grafting to obtain an acrylic acid modified polysulfone membrane (AA-PSF membrane); grafting sulfonated dihydroxypropyl chitosan (SDHPCS) on the surface of the AA-PSF membrane through a condensation reaction of carboxyl and amino to obtain the acrylic acid and sulfonated dihydroxypropyl chitosan modified polysulfone membrane (SDHPCS-AA-PSF membrane). The invention is characterized by adopting the polysulfone membrane as a base membrane, grafting the acrylic acid on the membrane surface and thengrafting the sulfonated dihydroxypropyl chitosan to obtain the acrylic acid and sulfonated dihydroxypropyl chitosan modified polysulfone membrane which has good hydrophilcity and blood anticoagulation; moreover, the preparation technology is simple, and the conditions are mild and easy to control.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a polysulfone membrane modified by acrylic acid and sulfonated dihydroxypropyl chitosan and a preparation method thereof. Background technique [0002] As a blood-contact material with great application potential, polysulfone is constantly improving its anticoagulant properties. There are no hydrophilic groups and anticoagulant molecules in the polysulfone membrane structure, so polysulfone itself has poor blood compatibility. When it comes into contact with blood, proteins will quickly adsorb to the surface of the membrane, and the adsorbed protein layer can further cause platelets to Adhesion, aggregation and coagulation, etc. The invention aims to solve the problems of protein adsorption and blood coagulation when the polysulfone material is used, and provides a modified polysulfone membrane with good blood compatibility and a preparation method thereof. [0003] At prese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/82B01D67/00
CPCB01D67/0006B01D71/82
Inventor 邱运仁王灿
Owner CENT SOUTH UNIV
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