Preparation method of hyperstable endovascular stent anticoagulant coatings

An anticoagulant and internal stent technology, applied in the field of biomedical materials, can solve problems such as poor stability, achieve the effects of increasing flexibility, reducing adhesion and aggregation, and improving anticoagulant performance

Inactive Publication Date: 2008-04-09
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the problem that the concentration of covalently bonded monolayer heparin is too low, and the ion-bonded polycation / heparin multilayer film prepared by electrostatic attraction layer-by-layer self-assembly technology has poor stability in polar solvents. Disadvantages: replace traditional polycations with diazo resins or multivalent cations, and use electrostatic attraction layer-by-layer self-assembly to modify the surface of intravascular stents to make them have good blood compatibility and tissue compatibility

Method used

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  • Preparation method of hyperstable endovascular stent anticoagulant coatings
  • Preparation method of hyperstable endovascular stent anticoagulant coatings
  • Preparation method of hyperstable endovascular stent anticoagulant coatings

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specific Embodiment approach 1

[0030] Specific implementation mode one: this implementation mode is realized in this way:

[0031] 1) Cleaning the intravascular stent material: Soak the Ni-Ti alloy in an organic solvent, sonicate for 1-120 min, and rinse with deionized water.

[0032] 2) use H 2 o 2 Boil the solution for 1-120 minutes, rinse with deionized water; etch with KOH solution for 1-120 minutes, rinse with deionized water.

[0033] 3) Electrostatic attraction self-assembled layer by layer diazo resin / heparin coating: put Ni-Ti alloy in 0.001-100mg / ml positively charged diphenylamine diazo resin solution, absorb for 0.5-30min, remove the solution and use Washing with deionized water; then putting the alloy into 0.001-100mg / ml negatively charged polyanion solution, absorbing for 0.5-30min, removing the solution and washing with deionized water. Repeat the above steps to assemble the diazo resin and polyanions alternately on the surface of the Ni-Ti alloy sheet until the required number of layers i...

specific Embodiment approach 2

[0043] Specific implementation mode two: this implementation mode is realized in this way:

[0044] 1) Electrostatic attraction layer-by-layer self-assembly of diphenylamine diazo resin and polyanion ultra-thin film including sodium alginate and heparin: put the Ni-Ti alloy sheet that has been oxidized and pretreated into 0.001~100mg / ml to be positively charged In the diphenylamine diazo resin solution, absorb for 0.5-30min, remove the solution and wash it with deionized water; then put the alloy sheet into 0.001-100mg / ml negatively charged polymer solution (sodium alginate or heparin), Adsorb for 0.5-30min, remove the solution and wash it with deionized water. Repeat the above steps to alternately assemble the diphenylamine diazo resin and polyanions on the surface of the Ni-Ti alloy sheet until the required number of layers is reached (the thickness is generally 1-1000 nm). After the reaction, the solution was taken out, washed with deionized water, and dried with nitrogen....

specific Embodiment approach 3

[0057] Specific implementation mode three: this implementation mode is realized in this way:

[0058] Electrostatic attraction layer by layer self-assembled multivalent metal cation solution and polyanion ultra-thin film including heparin: put the pretreated Ni-Ti alloy into 0.001-100mg / ml positively charged multivalent metal cation solution, Adsorb for 0.5-30min, remove the solution and shake and wash with deionized water; then put the alloy Ni-Ti into 0.001-100mg / ml negatively charged polyanion solution, the adsorption time is 0.5-30min, and wait for the adsorption of a layer of polyanion After anionization, the solution was removed and washed with deionized water, at which point the surface became negatively charged. Repeat the above steps to assemble metal ions and polyanions alternately on the surface of the Ni-Ti alloy sheet until the required number of layers is reached (the thickness is generally 1-10000nm). To prove that Fe 3+ And Hep can form a uniform multi-layer ...

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Abstract

The invention takes diazo-resin or multivalence metal ion solution as cross-linking agent. Through the electrostatic attraction LBL self-assembly technology, overstable endovascular stent graft anti-coagulation coating is prepared to lead the anti-coagulation coating to have good blood compatibility and tissue compatibility. The invention is realized in the following steps: a, the surface of an endovascular stent graft is cleaned, firstly, the surface of the endovascular stent graft is ultrasonically cleaned with multiple organic solvents for 1 to 120 minutes, and then the surface thereof is rinsed to be clean with water; b, oxidation treatment: H2O2 is boiled for 1 to 120 minutes, and then is rinsed with fresh water, KOH solution is etched for 1 to 120 minutes and then flushed to be clean with a large amount of fresh water; c, the preparation of the anti-coagulation coating: the diazo-resin with positive electricity and a polymer with anti-coagulation reactivity and / or the other polyanion solution are alternately deposited on the surface of the material through the electrostatic attraction function, ultraviolet light or visible light is adopted to irradiate surface coating of the material, through the photochemical reaction, ionic linkage between the inner layers of the coating is converted into covalent linkage, so as to attain the overstable anti-coagulation coating; or multivalence metal positive ion and the polymer or polyanion with anti-coagulation reactivity are alternately deposited on the surface of the stent graft material through the electrostatic attraction function, so as to attain the stable anti-coagulation coating.

Description

Technical field: [0001] The invention belongs to the field of biomedical materials, and relates to a method for modifying and modifying the anticoagulant surface of a stent in a blood vessel to make it have good blood compatibility and tissue compatibility. Background technique: [0002] According to reports, 3 million people around the world receive cardiovascular stent implantation every year. Among them, atherosclerotic heart disease is one of the causes of morbidity and death. This disease narrows the diameter of arteries and eventually blocks blood vessels. my country is a country with a large population, and the vascular defects and functional disorders caused by trauma and disease rank first in the world. Insertion of intravascular stents is an important method for the treatment of cardiovascular diseases. Percutaneous transluminal angioplasty (PTA), especially percutaneous transluminal coronary angioplasty (PTCA), is gradually becoming the basic method of vascular ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L33/10A61L29/02
Inventor 戴志飞刘萌岳秀丽于路邢雷
Owner HARBIN INST OF TECH
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