135 results about "Large population" patented technology

The invention relates to a method for identifying inherited point mutations in a targeted region of the genome in a large population of individuals and determining which inherited point mutations are deleterious, harmful or beneficial. Deleterious mutation are identified directly by a method of recognition using the set of point mutations observed in a large population of juveniles. Harmful mutations are identified by comparison of the set of point mutation observed in a large set of juveniles and a large set of aged individuals of the same population. Beneficial mutations are similarly identified.

A cell analysis and sorting apparatus is capable of monitoring over time the behavior of each cell in a large population of cells. The cell analysis and sorting apparatus contains individually addressable cell locations. Each location is capable of capturing and holding a specified number of cells, and selectively releasing that specified number of cells from that particular location. In one aspect of the invention, the cells are captured and held in wells, and released using vapor bubbles as a means of cell actuation. Disclosed are: a cell manipulation apparatus design; various resistive heater configurations for nucleating microbubbles; various well designs, each in communication with a nucleation chamber or channel, for capturing a specified number of cells; and methods of fabrication and cell population manipulation.

The present invention provides methods of designing PCR primers that allow the efficient and simultaneous amplification of a large number of different desired DNA fragments in a single multiplex PCR and minimize the formation of nonspecific extensions of undesired DNA fragments. The present invention allows a multiplex PCR to use at least 50 pairs of primers and produce at least 50 DNA fragments of interest. The present invention significantly broadens the application of multiplex PCR in the identification of multiple genes related to multifactorial diseases, the genome-scale detection of genetic alterations, the studies in large-scale pharmacogenetic reactions, the genotyping genetic polymorphism in a large population, the gene expression profiling in various samples, and high throughput genotyping technologies.

The subject invention relates to probabilistic models that are trained from transitions among various topics of pages visited by a sample population of search users. In one aspect, probabilistic models of topic transitions are learned for individual users and groups of users. Topic transitions for individuals versus larger groups are analyzed, wherein the relative accuracies of personal models of topic dynamics with models constructed from sets of pages drawn from similar groups and from a larger population of users are compared. To exploit temporal dynamics, the accuracy of these models are tested for predicting transitions in topics of visits at increasingly more distant times in the future. The models can be applied to search topic dynamics of tagged pages, and then utilized to predict topics of subsequent pages visited by users.

Fast and detailed match techniques for speaker recognition are combined into a hybrid system in which speakers are associated in groups when potential confusion is detected between a speaker being enrolled and a previously enrolled speaker. Thus the detailed match techniques are invoked only at the potential onset of saturation of the fast match technique while the detailed match is facilitated by limitation of comparisons to the group and the development of speaker-dependent models which principally function to distinguish between members of a group rather than to more fully characterize each speaker. Thus storage and computational requirements are limited and fast and accurate speaker recognition can be extended over populations of speakers which would degrade or saturate fast match systems and degrade performance of detailed match systems.

Disclosed is a system and method for generating a universally usable, completely automated public turing test to tell a computer and a human apart (CAPTCHA). The universally usable CAPTCHA uses contextually related pictures and sounds to present concepts to a user. The pictures allow the CAPTCHA to be used by someone who could see, and the audio would allow the CAPTCHA to be used by someone who could not see. This combination of sound and images should make the CAPTCHA more universally usable for a larger population of users than previously known CAPTCHAs.

An auto focus image system that includes an image sensor coupled to a controller. The image sensor captures an image that has at least one edge with a width. The controller generates a focus signal that is a function of the edge width. A lens receives the focus signal and adjust a focus. The edge width can be determined by various techniques including the use of gradients. A histogram of edge widths can be used to determine whether a particular image is focused or unfocused. A histogram with a large population of thin edge widths is indicative of a focused image.

A hybrid evolutionary algorithm (“HEA”) technique is described for automatically calculating well and drainage locations in a field. The technique includes planning a set of wells on a static reservoir model using an automated well planner tool that designs realistic wells that satisfy drilling and construction constraints. A subset of these locations is then selected based on dynamic flow simulation using a cost function that maximizes recovery or economic benefit. In particular, a large population of candidate targets, drain holes and trajectories is initially created using fast calculation analysis tools of cost and value, and as the workflow proceeds, the population size is reduced in each successive operation, thereby facilitating use of increasingly sophisticated calculation analysis tools for economic valuation of the reservoir while reducing overall time required to obtain the result. In the final operation, only a small number of full reservoir simulations are required for the most promising FDPs.

The effectiveness of advertisements with respect to a group of panelists is measured. Based on the results of such analysis, advertisements and/or variants thereof are selected for presentation to consumers. Effectiveness of advertisements is measured, in one embodiment, by detecting exposure to advertisements, and then monitoring panelist behavior following exposure to an advertisement. In one embodiment, the group of panelists is a representative sample of a larger population, so that observations of panelist behavior can be used as a basis for making decisions regarding presentation of advertisements to a larger audience having characteristics similar to those of the panelists.

Once the relative effectiveness for various audiences has been determined, advertisements can be selected for presentation to individual consumers or to groups of consumers, so as to maximize effectiveness. In one embodiment, such analysis and selection is performed substantially in real-time.

An auto focus image system that includes a pixel array coupled to a focus signal generator. The pixel array captures an image that has at least one edge with a width. The focus signal generator may generate a focus signal that is a function of the edge width and/or statistics of edge widths. A processor receives the focus signal and/or the statistics of edge widths and adjust a focus position of a focus lens. The edge width can be determined by various techniques including the use of gradients. A histogram of edge widths may be used to determine whether a particular image is focused or unfocused. A histogram with a large population of thin edge widths is indicative of a focused image.

The invention relates to a disinfector, and particularly relates to a traditional Chinese medicinal bactericidal freshening preparation for sterilizing a library. The traditional Chinese medicinal extracts of the traditional Chinese medicinal bactericidal freshening preparation are extracted from the following raw materials: astragalus membranaceus, coptis chinensis, cortex phellodendri, honeysuckle, agastache rugosus, folium eucalypti, mother chrysanthemum, liquorice, cordate houttuynia, folium artemisiae argyi, radix angelicae, angelica sinensis, gentiana lutea, rhizoma atractylodis, Eupatorium fortunei, cyrtomium fortune, fructus cnidii, rheum officinale, pepper, schizonepeta, mint and polygala tenuifolia. The traditional Chinese medicinal bactericidal freshening preparation also plays a role of freshening air when sterilizing and disinfecting. The effective components of the traditional Chinese medicinal bactericidal freshening preparation are the traditional Chinese medicinal extracts, so that the traditional Chinese medicinal bactericidal freshening preparation is free of toxic and side effects on a human body, also has the effects of clearing away heat and toxic materials, improving immune capability and the like, and is especially suitable for use in the library with large population flow and long detention time.

The invention discloses a method for mining user commuting OD in mobile phone call data. The number of calls of each mobile phone number in different base station locations; 3) Combine adjacent call base stations with overlapping coverage into one base station area, and count the number of calls of each mobile phone number in the base station area; 4) According to the number of calls of each mobile phone number in the base station area The number of calls determines the residence and work of the user of the mobile phone number, and the base station area with a high number of calls is the residence or work of the user. The method of the invention can obtain the commuting OD information of large-scale people, and has a wide coverage; because the data used is mobile phone call data, the cost is low; because the base station is used as the location unit, and the coverage of the base station is small, the obtained data information The granularity of the information obtained by the method of traditional commuter OD survey is finer.

The invention relates to a construction method of a cylindrical underground garage, belongs to the technology field of underground buildings, and aims to solve the technical problems of constructing an underground garage in an area with large population, small space and crowed buildings. The construction method comprises the following steps of: (1) performing preparation work including reinforcing the soil in a certain range around a well mouth, preparing a well mouth ring beam and a well drilling platform, and placing equipment and leveling; (2) drilling an underground vertical well pit; (3) performing slurry replacement when the drilled well reaches a designed depth and diameter; (4) installing a reinforced concrete well wall by sinking according to a suspension method; (5) correcting the verticality of the well wall after the well is sunk to a predetermined position, and backfilling the wall; (6) pumping out the counterweight water in the well pit; and (7) installing the in-well equipment and the ground appurtenant facilities. The inventive construction method has the advantages of low construction cost, short construction period, low construction difficulty, wide application range, and low influence on peripheral environment.

A method includes determining team participant members for one or more wellness teams. The method includes aggregating participant medical data for each of the one or more wellness teams from one or more networked physiologic stations configured to receive the medical data. The method includes analyzing the medical data to determine wellness information for the one or more wellness teams associated with the aggregated participant medical data. The method can be operated on a system where the system includes at least one physiologic station to generate participant medical information from a plurality of participants. This can include an identification component to facilitate trust in collected data. A storage medium collects the medical information over a network from the plurality of participants and an analyzer determines group wellness information from the collected medical information.

The present invention relates to the field of stem cell biology, in particular the lineage specific differentiation of pluripotent or multipotent stem cells, which can include, but is not limited to, human embryonic stem cells (hESC) in addition to nonembryonic human induced pluripotent stem cells (hiPSC), somatic stem cells, stem cells from patients with a disease, or any other cell capable of lineage specific differentiation. Specifically described are methods to direct the lineage specific differentiation of hESC and/or hiPSC into floor plate midbrain progenitor cells and then further into large populations of midbrain fate FOXA2+LMX1A+TH+ dopamine (DA) neurons using novel culture conditions. The midbrain fate FOXA2+LMX1A+TH+ dopamine (DA) neurons made using the methods of the present invention are further contemplated for various uses including, but not limited to, use in in vitro drug discovery assays, neurology research, and as a therapeutic to reverse disease of, or damage to, a lack of dopamine neurons in a patient. Further, compositions and methods are provided for differentiating midbrain fate FOXA2+LMX1A+TH+ dopamine (DA) neurons from human pluripotent stem cells for use in disease modeling, in particular Parkinson's disease. Additionally, authentic DA neurons are enriched for markers, such as CD142, and A9 type neuronal cells.

An advanced combat clothing system for military medics and medical professionals actively involved in the field of combat while providing acute emergency care for wounded soldiers. The Advanced Combat Uniform for Medics also referred to as the ACUM consists of a pair of trousers, a long sleeve shirt and a unique pocket receptacle invention which stabilizes the content within the pockets. The ACUM was invented to replace the use of roll-up bags and back packs used to carry the tools and supplies of the military medics during combat zone engagements.

The ACUM invention was strategically designed to disburse the weight of the medical gear over the entire body, therefore, decreasing the entire weight load from exerting pressure over the lumbar and thoracic spinal locations. Additionally, by disbursing the pay-load or weight over the entire body, the military medic will be able to maneuver and combat with more accuracy and precision.

The ACUM invention has a unique pull cord system in which the military medic can access lifesaving medicines and triage supplies at the pull of a cord. The ACUM can be made using any fabric including the digital camouflage material used and preferred by military personnel. The ACUM can hold over 100 required medical items while providing extremely fast easy access to the medical supplies carried by the military medics.

The ACUM invention was designed to systematically place all of the medical supplies carried by the military medic in strategic areas around the wearer's body. The ACUM can be made to fit any size, male or female. This combat uniform can be produced relatively quick and easy using a line production clothing protocol. Lumbar and spinal injury affects a large population of military personnel at one time or another, by disbursing the weight or load of the military medics gear; this will significantly reduce the risk of developing lumbar spinal disease in general.

A method and apparatus are disclosed for performing software guided prostate biopsy to extract cancerous tissue. The method significantly improves on the current system by accelerating all computations using a graphical processing unit (GPU) keeping the accuracy of biopsy target locations within tolerance. The result is the computation of target locations to guide biopsy using statistical priors of cancers from a large population, as well as based on previous biopsy locations for the same patient, and finally via mapping protocols with predefined needle configurations onto the patient's current ultrasound image.

An auto focus image system that includes a pixel array coupled to a focus signal generator. The pixel array captures an image that has at least one edge with a width. The focus signal generator may generate a focus signal that is a function of the edge width and/or statistics of edge widths. A processor receives the focus signal and/or the statistics of edge widths and adjust a focus position of a focus lens. The edge width can be determined by various techniques including the use of gradients. A histogram of edge widths may be used to determine whether a particular image is focused or unfocused. A histogram with a large population of thin edge widths is indicative of a focused image. Edge corruption/partial corruption may be detected. Partially corrupted edge may have edge width calculated by relying more on the side that is not corrupted and less on the side that is corrupted. Edge or edge side corruption may be detected by detecting a presence of an adjacent edge of the opposite sign.

The invention provides a safety monitoring method for a universal aerial vehicle and an unmanned aerial vehicle. The safety monitoring method aims at problems of single safety monitoring facility and low strength in existing low-altitude flight. Beidou RNSS and GPSL1 combined passive positioning technology, RDSS and ground cellular network communication technology are used for finishing flight state reporting and flight route service pushing of the universal aerial vehicle and the unmanned aerial vehicle. The safety monitoring method is characterized in that in cities and areas with large population density and ground cellular network coverage, comprehensive monitoring is performed through a ground secondary surveillance radar, ADS-B ground station equipment and Beidou/GPS double-mode positioning technology, thereby ensuring high accuracy of an aerial vehicle track; and in undeveloped and remote mountainous regions and areas without secondary surveillance radar or ADS-B ground station coverage, a lowest monitoring performance standard of the aerial vehicle is kept by means of Beidou/GPS double-mode positioning and Beidou RDSS communication. The safety monitoring method according to the invention is the low-altitude space domain safety monitoring method which has advantages of high universality, easy disposition and Chinese proprietary intellectual property right.

A large population of mass-produced devices (80) such as a particular model of computer hard disk drive, are distributed around the world. Each device (80) includes an arrangement for collecting failure analysis data of the device (50). Each device (80) is arranged to transmit this data to the device manufacturers server (10) via the internet (20). The server (10) analyses the data in order to determine trends in failure performance of the population of devices in order to improve future designs and to provide updated software for distribution to the devices (80) via the internet (20).

The invention relates to the technical field of classification treatment of plastic bottle materials, in particular to an automatic bottle cap separation machine for plastic bottles. The automatic bottle cap separation machine comprises a rack, a machine box, a direct-current drive motor, a driving intermittent gear, a driven intermittent gear, a center transmission shaft, a rotary disc, rotary arms, locating front concave plates, locating rear concave plates, springs, locking devices, a cam, a variable-speed motor, a spiral cutter, a claw-shaped bent hook, an arc-shaped sliding groove, an arc-shaped baffle, an arc-shaped pressing plate and the like. The combination manner of manual feeding and mechanical automatic machining is adopted for production, so that locating clamping, cutting, bottle cap and bottle mark separation, automatic recycling and a series of actions on the plastic bottles can be completed through the mechanical device. The automatic bottle cap separation machine is mainly used for regions with large population density and mobility such as shopping malls, supermarkets and schools; consumed empty bottles are directly put into the machine, the machine is started and conducts automatic machining, the machined bottle marks, bottle caps and bottle bodies automatically fall into corresponding collection boxes on the lower portion, no specially-assigned person is needed for operation, and manual handling is conducted after the collection boxes are full.