Lysine polyurethane medical material with surface modified by carboxymethyl chitosan and preparing method of lysine polyurethane medical material

Abstract

The invention discloses a lysine polyurethane medical material with the surface modified by carboxymethyl chitosan. A base layer is formed with a medical polyurethane material or a synthesized polyurethane material, and a modification layer is formed on the surface of the base layer through a chemical modification method. The modification layer contains carboxymethyl chitosan linked with a polyurethane substrate material through a covalent bond and lysine linked with carboxymethyl chitosan through a covalent bond by means of an active group on carboxymethyl chitosan. The invention further discloses a preparing method of the lysine polyurethane medical material with the surface modified by carboxymethyl chitosan. Reactivity points are generated on the surface of polyurethane through pre-activating treatment, then polyurethane and carboxymethyl chitosan are grafted and copolymerized, and the hydrophilia and biocompatibility of polyurethane as the medical material are improved; by introducing a second modification layer of lysine to the system, the anticoagulation property of polyurethane as the medical material is improved, production is simple, cost is low, and industrial popularization is easy.

Description

technical field [0001] The invention belongs to the technical field of medical macromolecule and its preparation, and specifically relates to a lysine polyurethane medical material with carboxymethyl chitosan surface modification and a preparation method thereof. Background technique [0002] Medical polyurethanes mostly refer to non-foaming elastomers with structural features of segmented polyurethane (SPU). Compared with other interventional catheter materials (such as PE, PVC, PTFE and silicone rubber), it has excellent mechanical properties and blood compatibility, and is currently an ideal material for making interventional catheters. SPU is composed of soft segment formed by polyether diol and hard segment formed by diisocyanate and chain extender low molecular weight diamine or diol. The domains of rigid hard segments are dispersed in the continuous phase of soft segments to form sea-island structures. Its hard segment is hydrophobic and partially crystalline, and t...

AI Technical Summary

Problems solved by technology

[0003] Although polyurethane has certain histocompatibility and blood compatibility, it still cannot fully meet the requirements of clinical application: for example, long-term implantation of polyurethane medical products in the body is likely to cause inflammatory reactions in the body, and direct contact with blood will inevitably different degrees of coagulation; in addition, polyurethane medical inserts or implants may also be accompanied by bacterial infection, body damage, etc.