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Coated heparin-immobilized hemoperfusion adsorbent and preparation method thereof

A technology of hemoperfusion and adsorbent, which is applied in the direction of blood circulation treatment, chemical instruments and methods, suction devices, etc., can solve problems such as shedding and poor blood compatibility, and achieve the effects of improving safety, reducing coagulation, and reducing particle shedding

Pending Publication Date: 2021-03-05
YUNNAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of this, in order to overcome at least one of the disadvantages of the above-mentioned prior art, the present invention provides a hemoperfusion adsorbent coated and immobilized with heparin and a preparation method thereof, wherein the hemoperfusion adsorbent is coated and simultaneously immobilized Heparin, to solve the problem of poor hemocompatibility and particle shedding of the adsorbent, and at the same time improve the anticoagulant performance of the adsorbent

Method used

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  • Coated heparin-immobilized hemoperfusion adsorbent and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0023] Add 3.0g of dopamine hydrochloride and 150mg of heparin sodium into 150mL of purified water to prepare 150mL of an aqueous solution containing 2.0% dopamine and 1g / L heparin, and put 100ml of hemoperfusion adsorbent (spherical resin, used for the adsorption of small and medium molecular toxins) into Soak in the solution and stir slowly for 24 hours, which is beneficial for dopamine and heparin to diffuse into the adsorbent. Then, 3.0 g of tris (Tris) was added to make the pH to 8.5, and the mixture was stirred slowly for 24 hours to obtain an adsorbent coated with polydopamine and immobilized with heparin. Finally, the adsorbent is collected by filtration, washed with purified water to remove uncoated heparin, and dried to obtain the finished adsorbent.

Embodiment 2

[0025] Add 1.5g of dopamine hydrochloride and 75mg of heparin sodium into 150mL of purified water to prepare 150mL of an aqueous solution containing 1.0% dopamine and 0.5g / L heparin, and place 100ml of hemoperfusion adsorbent (spherical resin, used for the adsorption of small and medium molecular toxins) Soak in the solution, and stir slowly for 12 hours, which is conducive to the diffusion of dopamine and heparin into the adsorbent. Then 1.5 mL of ammonia water was added to make the pH to 8.0, and the mixture was stirred slowly for 12 hours to obtain an adsorbent coated with polydopamine and immobilized with heparin. Finally, the adsorbent is collected by filtration, washed with purified water to remove uncoated heparin, and dried to obtain the finished adsorbent.

Embodiment 3

[0027] Add 0.75g of dopamine hydrochloride and 30mg of heparin sodium into 150mL of purified water to prepare 150mL of an aqueous solution containing 0.5% dopamine and 0.2g / L heparin, and place 100ml of hemoperfusion adsorbent (spherical resin, for small and medium molecular toxin adsorption) in Soak in the solution, and stir slowly for 12 hours, which is conducive to the diffusion of dopamine and heparin into the adsorbent. Then 1.5 g of sodium phosphate was added to make the pH 10, and the mixture was stirred slowly for 12 hours to obtain an adsorbent coated with polydopamine and immobilized with heparin. Finally, the adsorbent is collected by filtration, washed with purified water to remove uncoated heparin, and dried to obtain the finished adsorbent.

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Abstract

The invention relates to the technical field of blood purification, and discloses a coated heparin-immobilized hemoperfusion adsorbent and a preparation method thereof. The preparation method includesthe steps: soaking a hemoperfusion adsorbent in an aqueous solution of dopamine hydrochloride and heparin salt, and performing slow stirring at room temperature; and adjusting the pH value to be alkaline, continuously stirring at room temperature to realize coating of the polydopamine on the hemoperfusion adsorbent, and immobilizing the heparin on the adsorbent. The polydopamine generated in theinvention has strong adhesion and can be firmly coated on the hemoperfusion adsorbent to realize coating, the blood compatibility of the hemoperfusion adsorbent is improved, and the immobilized heparin has excellent anticoagulation performance and can reduce the blood coagulation phenomenon when blood is in contact with the adsorbent. The preparation method is simple and effective, is suitable forvarious hemoperfusion products clinically used at present, and improves the safety of clinical application.

Description

technical field [0001] The invention relates to the technical field of blood purification, more specifically, to a hemoperfusion adsorbent coated and immobilized with heparin and a preparation method thereof. Background technique [0002] Hemoperfusion adsorbent is a porous and high specific surface area medical consumable, which is mainly used for the adsorption of medium and large molecular toxins, the adsorption of bilirubin for liver diseases and the adsorption of pathogenic factors in the field of immunity. At present, the main application modes are single hemoperfusion mode, hemodialysis combined with hemoperfusion mode and plasma separation and adsorption mode. [0003] Hemoperfusion adsorbents are generally spherical resin or spherical activated carbon. During clinical use, blood cells (such as platelets) in the blood will adhere and gather on the surface of the adsorbent, causing coagulation. In addition, if the adsorbent is broken, it will also shed particles, cau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/32B01J20/20A61M1/36
CPCB01J20/3214B01J20/3285B01J20/3272B01J20/20A61M1/3679A61M1/3672A61M2202/0413A61M2202/0021
Inventor 张旭锋
Owner YUNNAN NORMAL UNIV
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