Preparation method of surface-heparinized anticoagulation medical device based on ionic bond-covalent bond synergistic action

A medical device, ionic bonding technology, applied in the direction of coating, etc., to achieve the effect of reducing adsorption behavior, prolonging the path of contact, and reducing biocompatibility

Active Publication Date: 2019-07-19
JIANGSU STMED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Covalently bonded heparin is relatively stable, but it also has certain defects, mainly because heparin is easily bound to the surface of the material at multiple points, making its conformation difficult to change and affecting its anticoagulant effect

Method used

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  • Preparation method of surface-heparinized anticoagulation medical device based on ionic bond-covalent bond synergistic action
  • Preparation method of surface-heparinized anticoagulation medical device based on ionic bond-covalent bond synergistic action
  • Preparation method of surface-heparinized anticoagulation medical device based on ionic bond-covalent bond synergistic action

Examples

Experimental program
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Effect test

Embodiment 1

[0038] Example 1 A method for preparing an anticoagulant medical device based on ionic bond-covalent bond synergistic surface heparinization

[0039] An anticoagulant medical device based on ionic bond-covalent bond cooperative surface heparinization, the preparation method of which is as follows:

[0040] (1) Based on the hydrophilic polymer with a large amount of double bonds in the side chain, prepare the hydrophilic polymer with low molecular weight hyperbranched PEI in the side chain: 5g ethylene oxide and 2g allyl glycidyl ether are separated by anion Cyclocopolymerization reaction to obtain a hydrophilic polyethylene oxide (PEO) polymer containing a large number of double bonds; add 2g mercaptoethanol and 1g AIBN, and carry out addition reaction at 80°C for 48h, so that all the double bonds in the side chain are converted into hydroxyl groups ; Use 2g 4-NC to activate the hydroxyl group in the hydrophilic polymer to obtain a hydrophilic PEO polymer with a side chain mod...

Embodiment 2

[0045] Example 2 A method for preparing an anticoagulant medical device based on ionic bond-covalent bond synergistic surface heparinization

[0046] An anticoagulant medical device based on ionic bond-covalent bond cooperative surface heparinization, the preparation method of which is as follows:

[0047] (1) Based on the hydrophilic polymer with a large number of double bonds in the side chain, prepare a hydrophilic polymer with a low molecular weight hyperbranched PEI in the side chain: 2g ethylene glycol and 0.5g allyl glycidyl ether are opened by anion Copolymerization reaction to obtain a hydrophilic polyethylene glycol (PEG) polymer with a large number of double bonds in the side chain; add 0.5g mercaptoethanol and 1g AIBN, and carry out addition reaction at 50°C for 24h, so that all the double bonds in the side chain are converted into Hydroxyl; use 0.2g 4-NC to activate the hydroxyl group in the hydrophilic polymer to obtain a hydrophilic PEG polymer with NC-modified ...

Embodiment 3

[0052] Example 3 A method for preparing an anticoagulant medical device based on ionic bond-covalent bond synergistic surface heparinization

[0053] An anticoagulant medical device based on ionic bond-covalent bond cooperative surface heparinization, the preparation method of which is as follows:

[0054] (1) Based on the hydrophilic polymer with a large number of double bonds in the side chain, prepare a hydrophilic polymer with a low molecular weight hyperbranched PEI side chain: 10g α, ω-aminopropyl-ethylene glycol and 5g allyl shrink Glyceryl ether was obtained by anionic ring-opening copolymerization reaction to obtain a hydrophilic α, ω-aminopropyl-polyethylene glycol polymer modified with double bonds; adding 10 g mercaptoethanol and 5 g AIBN, and carried out the addition reaction at 100 ° C for 48 h, so that The double bonds of the side chains are all converted into hydroxyl groups; 5g of 4-NC is used to activate the hydroxyl groups in the hydrophilic polymer to obtai...

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Abstract

The invention relates to the field of medical devices, in particular to a preparation method of a surface-heparinized anticoagulation medical device based on ionic bond-covalent bond synergistic action. The method comprises the following steps: firstly, fixing heparin on the surface of a medical device by utilizing a hydrophilic polymer modified by low-molecular-weight hyperbranched polyethyleneimine as a side chain in an ionic bond combination manner; and furthermore, grafting a stable heparin coating through covalent bonds, so as to obtain the anticoagulant biomedical device with high anticoagulant activity and high anticoagulant stability. The device has a wide application value in the field of biomedical treatment. The method is simple in preparation process, high in controllability and low in material price, does not involve toxic reagents in the experiment process, has universality for various medical device structures, and is suitable for industrial production.

Description

[0001] Technical field: [0002] The invention relates to the field of medical devices, in particular to a method for preparing an anticoagulant medical device based on ionic bond-covalent bond synergistic surface heparinization. [0003] Background technique: [0004] Biomaterials are a class of materials applied to living organisms (mainly the human body), which need to be in contact with blood, organs, tissues, etc. of the human body during use. When the blood comes into contact with the surface of the material, plasma proteins (including some coagulation factors and anticoagulation factors) are easily adsorbed on the surface of the material to generate denaturation or activation, causing platelet coagulation reaction, resulting in the interaction of insoluble fibrin and platelets to form thrombus. Therefore, biomedical polymer materials must not only have good physical and mechanical properties, chemical stability, non-toxicity, and easy processability, but also must have g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08J7/04C08L101/00
CPCC08J7/12C08J2300/00C08J2405/10C08J7/0427
Inventor 王维宁张晓红陈大竞魏晨杰黄赋
Owner JIANGSU STMED TECH CO LTD
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