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Method for constructing hemocompatible material surface with bionic periodic structure

A blood compatibility and construction method technology, applied in the design and manufacture of bionic micro-nano structures, can solve problems such as blood coagulation, achieve the effects of improving material surface friction, reducing side effects, and safe and reliable use

Inactive Publication Date: 2012-06-20
EAST CHINA JIAOTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The surface of the material should avoid blood stagnation or eddy currents. The higher the roughness of the material, the greater the area exposed to the blood, and the greater the possibility of coagulation; but on the contrary, the smooth surface of the glass is also very serious.

Method used

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  • Method for constructing hemocompatible material surface with bionic periodic structure
  • Method for constructing hemocompatible material surface with bionic periodic structure
  • Method for constructing hemocompatible material surface with bionic periodic structure

Examples

Experimental program
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Effect test

Embodiment 1

[0034] 1. Periodic surface structure design. According to the designed geometric model, the apparent contact angle calculation formula of the periodic structure surface is deduced based on the classical wetting theory, and the appropriate geometric structure size is determined according to the formula to meet the ideal superhydrophobic surface requirements. take side length a 10 mm, square column spacing b 20 mm, height h The apparent contact angle of the lower surface of the structure of this size is greater than 150°, which is superhydrophobic.

[0035] 2. Production of silicon-based hard (rigid) templates. Use photolithography to carve a periodic array of square pillars on the silicon substrate according to a pre-designed periodic microstructure pattern, and the side length of the micropillars a 10 mm, square column spacing b 20 mm, height his 5mm. First, clean the silicon wafer sample, and treat it at 180°C for more than 4 hours to remove surface water molecules, an...

Embodiment 2

[0041] 1. Periodic surface structure design. take side length a 20 mm, square column spacing b 50 mm, height h The apparent contact angle of the lower surface of this size structure is greater than 150°, which is superhydrophobic.

[0042] 2. Production of K9 glass hard template. Use photolithography to carve a periodic array of square pillars on the silicon substrate according to a pre-designed periodic microstructure pattern, and the side length of the micropillars a 20 mm, square column spacing b 50 mm, height h is 20mm. First, clean the K9 glass sample, and treat it at 180°C for more than 4 hours to remove surface water molecules, and use a thick glue spinner (Karl Suss, Germany, RC8) to spin-coat SU with the required thickness on the surface of K9 glass. -8 photosensitive resin, the thickness of the SU-8 layer can be controlled by adjusting the speed and time of glue rejection. Then, pre-baking the SU-8 glue was performed in a programmed oven, and a photoresist mo...

Embodiment 3

[0048] 1. Periodic surface structure design. take side length a 50 mm, square column spacing b 100 mm, height h The apparent contact angle of the lower surface of this size structure is greater than 150°, which is superhydrophobic.

[0049] 2. Production of titanium dioxide hard template. Use photolithography to carve a periodic array of square pillars on the silicon substrate according to a pre-designed periodic microstructure pattern, and the side length of the micropillars a 50 mm, square column spacing b 100 mm, height h is 25 mm. Firstly, the titanium dioxide sample was cleaned and treated at 180°C for more than 4 hours to remove surface water molecules, and the surface of the silicon wafer was spin-coated with SU- 8 Photosensitive resin, the thickness of the SU-8 layer can be controlled by adjusting the speed and time of glue rejection. Then, pre-baking the SU-8 glue was performed in a programmed oven, and a photoresist model was obtained by contact exposure on a...

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Abstract

The invention relates to a method for constructing a hemocompatible material surface with a bionic periodic structure. The method comprises the following steps of: deducing a theoretical prediction formula of surface appearance contact angle of the periodic micro-structure surface according to a micro-pillar surface model, and determining whether the designed micro-structure surface has ideal super-hydrophobicity according to the formula; etching to form a micro-pillar hard template with array structure according to the periodic micro-structure, casting PDMS (polydimethylsiloxane) on the hard template, allowing cross-linking and curing of the PDMS, and stripping off the cured film as an elastic template; and casting a prepolymer on the elastic template, and curing to form a micro-pattern on the polymer surface, which is complementary to the elastic template but similar to the original template. The bionic hemocompatible material constructed by the invention can effectively inhibit adhesion and deformation of platelets, prevent activation of coagulation pathway and increase duration of anticoagulation. Besides, the wetting property of the interface is improved by reasonable regulation of surface geometric dimension, so that the hemocompatibility of the material is improved.

Description

technical field [0001] The invention relates to a method for constructing a blood-compatible material surface with a bionic periodic structure, and belongs to the technical field of design and manufacture of bionic micro-nano structures. Background technique [0002] Contact between blood and materials can lead to adverse consequences such as hemolysis and thrombosis. Over the years, researchers have been developing new biomaterials and surface modification of existing biomaterials through various approaches. For the former, such ideal blood-compatible materials have not been found yet. For the latter, it is often modified by coating antithrombotic drugs (anticoagulants) on the surface of materials without blood compatibility or poor compatibility, in order to reduce the occurrence of blood coagulation, but this method uses After anticoagulants such as heparin enter the blood circulation, they will interfere with the self-stabilization of the blood coagulation system and b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C39/02B29C39/22B29C33/38C08J7/12C08L83/04
Inventor 李刚
Owner EAST CHINA JIAOTONG UNIVERSITY
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