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Anticoagulation medical device, and preparation method thereof

A medical device and anti-coagulation technology, which is applied in anti-coagulation treatment, medical packaging, packaging, etc., can solve the problems that medical devices cannot be modified, cannot meet medical devices, and the preparation process is complicated, so as to avoid polyelectrolyte agglomeration , Improve anticoagulation, simple process effect

Inactive Publication Date: 2016-01-13
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these surface modification methods generally have weaknesses such as solvent toxicity, complicated preparation process, and poor controllability, which not only greatly limit the designability of the material surface, but also cannot realize the modification of medical devices with complex geometric shapes. Meet the needs of the rapid development of medical devices

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1) Prepare a positively charged polyelectrolyte citrate solution, the pH value of the positively charged polyelectrolyte solution is preferably 3.5-4.5, and the concentration of the polyelectrolyte is preferably 0.015mg / mL-0.15mg / ml; Negatively charged polyelectrolyte citrate solution, the pH value of the negatively charged polyelectrolyte solution is preferably 2.5-4.5, and the concentration of the polyelectrolyte is preferably 0.10 mg / mL-1.00 mg / mL. The charged polyelectrolyte solutions are respectively subjected to ultrasonic treatment; the operating frequency of the ultrasonic treatment is preferably 25 kHz, and the ultrasonic time is preferably 2-5 minutes.

[0031] 2) Circulate the positively charged polyelectrolyte citrate solution over the surface of the device body for 15-30 minutes, and then rinse with purified water with a pH value of 4.5 for 2 minutes.

[0032] 3) The negatively charged polyelectrolyte citrate solution is circulated over the surface of the d...

Embodiment 2

[0038] A peristaltic pump was used to circulate albumin citrate solution (pH 3.5) with a concentration of 0.15 mg / ml through the bipolar femoral venous cannula for 15 minutes, and then rinsed with purified water (pH 4.5) for 2 minutes to obtain albumin physisorption. Surface; 0.10mg / ml heparin sodium citrate solution (pH4.5) was circulated through the bipolar femoral vein catheter with a surface of positively charged albumin for 30min, and purified water (pH4.5) was rinsed for 2min to obtain The surface of negatively charged anticoagulant heparin; albumin citrate solution (pH3.5) at a concentration of 0.15 mg / ml was circulated through the bipolar femoral vein cannula with negatively charged heparin sodium for 15 min, purified water ( pH 4.5) rinsed for 2 min to obtain a bipolar femoral vein cannula with positively charged albumin on the surface, thereby obtaining a 3-layer alternating coating surface of positively charged albumin and negatively charged heparin sodium; 1-ethyl-(...

Embodiment 3

[0041] A peristaltic pump was used to circulate albumin citrate solution (pH 4.5) with a concentration of 0.10 mg / ml through the oxygenation chamber of the membrane oxygenator for 15 minutes, and then rinsed with purified water (pH 4.5) for 2 minutes to obtain a positively charged white The surface of protein physical adsorption; the concentration of 0.15mg / ml heparin sodium citrate solution (pH4.5) was circulated through the membrane oxygenator oxygenation chamber whose surface was positively charged albumin for 20min, purified water (pH4. 5) Rinse for 2 min to obtain the surface of negatively charged polyanionic anticoagulant heparin; circulate the albumin citrate solution (pH 4.5) with a concentration of 0.10 mg / ml through the membrane of the negatively charged polyanionic sodium heparin on the surface The oxygenation chamber of the type oxygenator was used for 15 minutes, and the purified water (pH 4.5) was rinsed for 2 minutes to obtain the oxygenation chamber of the membr...

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Abstract

The invention discloses an anticoagulation medical device, and a preparation method thereof. The preparation method comprises following steps: a, a device main body of the anticoagulation medical device is prepared; and b, the surface of the device main body is coated with a positively charged polyelectrolyte and a negatively charged polyelectrolyte via alternate adsorption so as to form a coating layer and obtain the anticoagulation medical device. The preparation method also comprises a step of crosslinking of the positively charged polyelectrolyte with the negatively charged polyelectrolyte using a cross-linking agent. The preparation method is simple; preparation can be realized using a simple solution circulating device; a stable coating structure can be obtained via crosslinking; preparation can be carried out at mild aqueous environment; no toxic solvent is used; the preparation method is friendly to the environment; no special requirement on the shape structure of the anticoagulation medical device is required by the preparation method; and preparation can be realized on the surfaces of a plurality of medical devices with complex structures.

Description

technical field [0001] The invention relates to a medical device and a preparation method thereof, in particular to an anticoagulation medical device and a preparation method thereof. Background technique [0002] Biomaterials are a class of materials that have special properties and functions, and are used in artificial organs, surgical repair, diagnosis, examination, treatment of diseases and other medical and health care fields without adverse effects on human tissue and blood. As a biological material, it must have good biocompatibility, which includes blood compatibility and histocompatibility. Among them, hemocompatibility has more stringent requirements on biomaterials than histocompatibility. [0003] For devices in contact with blood, such as extracorporeal circulation devices, interventional therapy systems, artificial blood vessels and artificial organs such as artificial hearts, blood compatibility is particularly important. Contact of these devices and related...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/14A61L27/34A61L27/50A61L33/12A61L33/10A61L33/08
Inventor 陈大凯杜广武梁灿权闫冬环刘鹏罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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