62results about How to "Long release" patented technology

Methods are provided for decreasing the amount of nitrogen oxides released to the atmosphere as a component of combustion emissions. The methods are carried out by forming a combustion flue gas in a combustion zone, the combustion flue gas including nitrogen oxides, injecting overfire air and droplets of a solution or a powder of a selective reducing agent into a burnout zone, and contacting the combustion flue gas with the overfire air and the selective reducing agent in the burnout zone to thereby decrease the concentration of nitrogen oxides therein. The selective reducing agent is provided in an aqueous solution or powder which is injected into the overfire air in optimized droplet or particle form prior to or concurrently with injection of the overfire air into the burnout zone.

The invention provides a material with multi-functional long-acting slow-release effective components. The material is prepared by a porous charcoal material, a health-care active substance with volatility and a functional material through mixing, adding a natural adhesive and forming, or is prepared by the porous charcoal material and the functional material through soaking in a health-care active substance solution with volatility or spraying the solution thereof after mixing, adding the natural adhesive, forming and drying. The material not only can widely and persistently release the effective components but also can adsorb noxious gas in the air. According to applications, the material can be applied to the purification of the air, the refreshing of space, sterilization, insect prevention, parasite expelling, long-acting medication, prevention, treatment, health care, humidity adjusting and the release of far infrared rays and negative ions which are beneficial to a human body.

Biodegradable resorbable drug delivery systems characterized by an electrospun biodegradable resorbable polymeric fiber matrix with at least one therapeutic agent incorporated into the fibers of the matrix, wherein the fiber matrix has an interfibrillar space of at least 65% by volume. Therapeutic methods for delivering a chemotherapeutic agent to body cavities from which a tumor has been excised and for strengthening weakened blood vessel walls are also disclosed.

Controlled release dosage formulations for the delivery of one or more HIF-1 inhibitors are provided. The controlled release formulations contain one or more HIF-1 inhibitors conjugated to or dispersed in a polymeric vehicle. The one or more HIF-1 inhibitors can be dispersed or encapsulated in a polymeric matrix. In some embodiments, the one or more HIF-1 inhibitors are covalently bound to a polymer, forming a polymer-drug conjugate. Polymeric vehicles can be formed into implants, microparticles, nanoparticles, or combinations thereof. Controlled release HIF-1 formulations provide prolonged therapeutic benefit while lowering side effects by releasing low levels of one or more HIF-1 inhibitors and / or HIF-1 inhibitor conjugates over a prolonged period of time. Controlled release dosage formulations can be used to treat or prevent a disease or disorder in a patient associated with vascularization, including cancer, obesity, and ocular diseases such as wet AMD.

A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as “hydrophobic compounds”) is integrated into a polymeric matrix for drug delivery to alter drug release kinetics. In embodiments where the drug is water soluble, the drug is released over longer periods of time as compared to release from the polymeric matrix not incorporating the hydrophobic compound into the polymeric material. In contrast to methods in which a surfactant or lipid is added as an excipient, the hydrophobic compound is actually integrated into the polymeric matrix, thereby modifying the diffusion of water into the microparticle and diffusion of solubilized drug out of the matrix. The integrated hydrophobic compound also prolongs degradation of hydrolytically unstable polymers forming the matrix, further delaying release of encapsulated drug.

The invention discloses a preparation method of an anticoagulant material with function of inducing and catalyzing release of endogenous NO. The method comprises the steps of: configuring an alkaline Tris-buffer buffer solution, and adding a compound with certain concentration and pyrogallol structure and a compound with disulfide bond or diselenium bond and containing amino or thiol at two ends; and placing the substrate materials in a reaction solution, controlling the reaction temperature, reacting for 1-24 h, removing the substrate, and cleaning and drying to obtain the objective material. The invention has the advantages of simple operation, mild reaction conditions and easy operation. The component unit of the compound with disulfide bond or diselenium bond and containing amino or thiol at two ends has controllable content; the modified coating prepared by the method has excellent adhesion, and catalyzes the blood NO donors to continuously release NO molecules through in situ catalysis, inhibits activation and aggregation of platelets, inhibits proliferation of smooth muscle cells, and protects vascular endothelium.

The invention relates to a method for preparing a small molecule hydrophilic drug-embedded sustained-release capsule. The method comprises the following steps: filtering a prepared'internal aqueous phase / oil phase / external aqueous phase' pre-multi-emulsion solution through a microporous membrane; and then removing a solvent, washing and drying to obtain the small molecule hydrophilic drug-embedded sustained-release capsule, wherein the internal aqueous phase comprises a small molecule hydrophilic drug and a thickening agent. The small molecule hydrophilic drug-embedded sustained-release capsule provided by the invention has the advantages of uniform grain diameter, high embedding rate, low burst-release rate, stable drug release and long action.

A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as “hydrophobic compounds”) is integrated into a polymeric matrix for drug delivery to alter drug release kinetics. In embodiments where the drug is water soluble, the drug is released over longer periods of time as compared to release from the polymeric matrix not incorporating the hydrophobic compound into the polymeric material. In contrast to methods in which a surfactant or lipid is added as an excipient, the hydrophobic compound is actually integrated into the polymeric matrix, thereby modifying the diffusion of water into the microparticle and diffusion of solubilized drug out of the matrix. The integrated hydrophobic compound also prolongs degradation of hydrolytically unstable polymers forming the matrix, further delaying release of encapsulated drug.

Agents for treating textiles or surfaces, which contain at least one fragrance and at least one esterquat with the general formula (I): [N+R1R2R3R4]X− that contains an OH group. The use of agents for treating textiles or surfaces to prolong the fragrant scent of detergents, cleaning agents, fabric softeners, or solid surfaces treated with these agents, and method for producing them.

The invention discloses a negative oxygen ion photocatalyst decomposition liquid for formaldehyde removal and a preparation method thereof. The liquid is prepared from 14 parts of a formaldehyde trapping agent, 3-5 parts of a nano photocatalyst, 3-5 parts of nano silver ions, 4-6 parts of negative ion powder, 6-10 parts of cellulose, 3-5 parts of ethanol, 0.3-0.7 part of essence and 75.3-80.5 parts of deionized water. The negative oxygen ion photocatalyst decomposition liquid for formaldehyde removal and the preparation method thereof have an excellent catalytic degradation function, can release negative oxygen ions for a long time and can thoroughly kill bacteria and microorganisms since the formaldehyde trapping agent, high-activity nano Ti02 and Ag+ with a high-efficiency sterilizationfunction are added. Harmful gas such as formaldehyde, benzene, VOC and the like brought by the bacteria, the microorganisms and decoration can be thoroughly caught and decomposed, spatial structures of organic molecules are changed and convert into tasteless and harmless molecules, negative oxygen ions are released, sterilization and disinfection are carried out, and therefore indoor air is thoroughly and effectively purified.

The invention discloses a method for preparing a hydrophobic medicament nuclear shell structure micro / nano granule-type solid dispersion by a high-voltage static electricity spraying method, relating to the pharmaceutics and biomedical field. The method comprises the following steps of: dissolving hydrophobic medicaments and fat soluble high polymer materials together into an organic solvent, and emulsifying and dispersing the mixture into an aqueous solution containing water soluble high polymer material; then placing oil-in-water emulsion into a trace propeller, and carrying out electrostatic spraying under the effect of high-voltage electrostatic field, thereby obtaining the hydrophobic medicament nuclear shell structure micro / nano granule-type solid dispersion finally. According to the preparation method, the operation is simple, the cost is low, environmental protection is realized and industrial production is facilitated. The particle size of the prepared hydrophobic medicament nuclear shell structure micro / nano granule-type solid dispersion is controllable, and the solid dispersion has tissue and organ targeting; and the granules of the nuclear shell structure is beneficial to prolonging the medicament action time.

Disclosed is a drug delivery system for delivering a drug at a sustained constant rate for a long period, which can be transplanted into an affected part safely and in a simple manner and can deliver a drug to the affected part for a long period. Specifically disclosed is a sustained drug delivery system in which an implant is implanted into a body, wherein the implant is a PEG capsule comprising a box-shaped PEG and a porous PEG sheet.

The invention discloses an environment-friendly negative-oxygen-ion nanofilm and a preparation method thereof. The environment-friendly negative-oxygen-ion nanofilm is mainly prepared from the following components by mass: 25 to 40 parts of bamboo charcoal powder, 18 to 30 parts of polyethylene glycol, 12 to 25 parts of extract of cactus with globular stem, 12 to 22 parts of extract of Scindapsus aureus, 13 to 30 parts of polycarbonate, 8 to 25 parts of dimethylammonium formate, 8 to 24 parts of methyl acrylate, 12 to 28 parts of polyacrylamide and 25 to 50 parts of water. Compared with the prior art, the invention has the following advantages: (1) the environment-friendly negative-oxygen-ion nanofilm prepared in the invention can release negative oxygen ion for a long time so as to increase the content of indoor negative ions, so the nanofilm is beneficial for human health; and (2) the environment-friendly negative-oxygen-ion nanofilm prepared in the invention can adsorb indoor bacteria, thereby achieving the purpose of purifying air.

The invention discloses a wild aloe health paint. The paint comprises the following components by weight percent: 8-18% of clean tap-water, 0.5-1.0% of dispersant, 0.1-0.2% of surfactant, 0.1-0.2% of pH regulator, 0.4-0.8% of antifoaming agent, 0.8-3.5% of ethylene glycol, 10-25% of titanium white powder, 0.2-5% of aloe powder, 5-25% of diatomite, 15-35% of emulsion, 2-5% of negative ion additive, 0.8-1.5% of polyurethane thickener, 0.2-0.7% of acrylic thickener, 0.1-0.2% of preservative, 0.2-0.7% of mildewproof agent and 1-2.5% of film forming additive. The invention aims to overcome the defects of the prior art and provide the wall paint for interior wall, wherein the wall paint can release negative ions persistently, absorb indoor formaldehyde, purify the air, have the effects of antibacterial property, mildew-proof property, algae-proof property, humidifying property, sound attenuating and antistatic property, integrate the water-proof property and alkali resistance of the paint film with the dicoration perfectly and create a comfortable human environment.

The invention relates to a fluoridated dental composite resin material contributing to resisting secondary caries, and belongs to the field of dental preparations. The conventional simple villiaumite-blended composite resin caries-filling material has the problems of too quick fluorine release, poor interfacial compatibility and no rigid support for a caries-filling body, and the scheme aims to solve the problems. The fluoridated dental composite resin material comprises the following components in percentage by weight: 20 to 85 percent of nano inorganic powder of which the surface is modified by a silane coupling agent, 8 to 70 percent of bisphenol A glycidyl methacrylate resin monomer, 5 to 25 percent of triethylene-glycol dimethacrylate diluent, 0.25 to 2 percent of camphorquinone photoinitiator, and 0.5 to 3 percent of dimethylamino ethyl methacrylate coinitiator; and importantly, the nano inorganic powder comprises 10 to 80 weight percent of fluorine-carrying mesoporous silica microspheres which can slowly release fluorine and strengthen the composite resin.

The invention discloses a long-acting hydrophobic anti-ice coating which comprises a material A, a material B and paraffin powder, wherein the material A includes polyurethane, a long-acting hydrophobic anti-ice agent and a polyurethane curing agent; the material B includes a water-borne epoxy resin and a water-borne epoxy resin curing agent. The long-acting hydrophobic anti-ice coating disclosedby the invention is capable of effectively preventing pavement from icing under frozen, rainy and snowy weather and is capable of achieving the effects of thawing and damaging the ice layer and thinning the ice layer under extremely severe weather; a snow thawing agent is continuously released under the vehicle load on pavement and is capable of exerting a long-acting stable effect; after such a long-acting hydrophobic anti-ice coating is directly adhered to the bituminous pavement or is roll-coated on the bituminous pavement, the freezing disaster of pavement can be effectively reduced; the long-acting hydrophobic anti-ice coating has a great significance in guaranteeing traffic safety under icy and snowy weather.

The invention relates to a venlafaxine hydrochloride sustained-release capsule and a preparation method thereof, wherein the sustained-release capsule is composed of a sustained-release pillet and a capsule shell; the substrate of the sustained-release pillet is an inert pillet core; and a fluidized bed respectively comprises a medicine layer, an isolation layer and a sustained-release layer. Compared with the traditional rolling extrusion method, the preparation method disclosed by the invention is simple; and simultaneously, because of optimal selection of a coating layer, long-term release of medicines can be realized.

The present invention provides a high inertia flywheel for a vehicle including a hub, a periphery of which is surrounded by a rim, and a housing, wherein at least one annular ring is provided on either side of the flywheel, whereby, on oscillation of the flywheel, a contact surface of the flywheel contacts against a contact surface of the annular ring, thus causing friction.

The invention provides a corn starch film containing rutin composite nanoparticles and a preparation method of the corn starch film. The rutin composite nanoparticles in the corn starch film are prepared by embedding rutin in corn prolamine. The rutin composite nanoparticles have the performance of slowly releasing the rutin, so that the corn starch film prepared by the method has long-acting oxidation resistance. According to the corn starch film disclosed by the invention, instruments of a physical property determinator, a Fourier transform infrared spectrum analyzer, a scanning electron microscope and the like are adopted for analyzing the representational structure of the corn starch film, and the light transmittance, the water solubility, the moisture permeability, the surface color, the mechanical performance, the slow release efficiency and the oxidation resistance of the corn starch film are determinated. A result shows that after the rutin composite nanoparticles are added in the corn starch film, the property of the corn starch film is improved to some extent; discovered by determination on the property of the corn starch film, hydrogen bonds and electrostatic interaction can be formed by the rutin composite nanoparticles and a starch substrate, the property of the corn starch film is strengthened to a certain degree, and the corn starch film is enabled to have a certain slow release ratio and stronger oxidation resistance.

The invention discloses a magnesium ammonium phosphate-urea slow-release fertilizer and a preparing method thereof, and belongs to the technical field of resource comprehensive utilization. The methodincludes the following steps of firstly, grinding magnesium ammonium phosphate and modified starch into small particles, and conducting evenly mixing to form a magnesium ammonium phosphate and modified starch mixture; secondly, placing the mixture obtained in the first step into a disc granulator; thirdly, spraying water on the rotating magnesium ammonium phosphate and modified starch particles through an atomizing method; fourthly, slowing adding the urea ground into small particles to the magnesium ammonium phosphate and modified starch particles in the third step; fifthly, spraying water for granulating; sixthly, repeatedly executing the second step, the third step, the fourth step and the fifth step through the slow adding mode after the material is converted into the particles with the granularity of about 1 mm; seventhly, conducting stable granulating to obtain the magnesium ammonium phosphate-urea slow-release fertilizer. The magnesium ammonium phosphate-urea slow-release fertilizer particles are formed with the magnesium ammonium phosphate particles and the urea particles through the layer-by-layer wrapping mode, and the releasing speed of the urea is effectively controlled.

The invention relates to a middle ear anti-adhesion medicine slow-release system and a preparation method and application thereof. The middle ear anti-adhesion medicine slow-release system comprises adiaphragm, a coating covering the diaphragm and medicines, wherein the medicines are loaded onto the diaphragm and the coating. The middle ear anti-adhesion medicine slow-release system has a structure of the internal diaphragm and the external coating, and both the diaphragm and the coating are loaded with the medicines so that the medicines can be released fast, and long-acting release can be achieved; by controlling intrinsic viscosity of diaphragm preparation raw materials and coating preparation raw materials and controlling a mass ratio of the medicines contained in the diaphragm and the coating, a medicine release curve can be made to be more smooth, and a medicine release process can be made to be more stable.

The invention relates to the technical field of cosmetics, and discloses a long-acting moisturizing sustained-release microsphere applied to a make-up base and a preparation method of the long-acting moisturizing sustained-release microsphere in order to solve the problems that an existing make-up base is poor in moisturizing and skin care persistence and a sustained-release condition of sustained-release microspheres in the make-up base is harsh. The sustained-release microsphere is internally filled with porous hydrogel and essence; the surface of the sustained-release microsphere is subjected to hole sealing by adopting a photolysis polymer, and the essence in the sustained-release microsphere is slowly released under the expansion and extrusion function of the porous hydrogel under the action of illumination; the essence comprises the following components in parts by weight: 2-5 parts of shea butter, 4-6parts of squalane, 10-15 parts of hyaluronic acid, 1-3 parts of vitamin E and 8-10 parts of n-butyl alcohol. The sustained-release microsphere is filled with the porous hydrogel which swells under an illumination condition, in addition, the porous hydrogel is full of the essence, a polymer which is cracked under the illumination condition is adopted for carrying out the hole sealing on the sustained-release microspheres, so that long-acting sustained release of the essence in the sustained-release microsphere is finally realized, and a relatively good moisturizing and skin-care effect is achieved.

The present invention provides sustained-release preparations from which a pharmacologically active substance can be released over a long time and a process for producing the same. Such a sustained-release preparation is produced by melt-granulating a low-melting-point substance and a pharmacologically active substance and melt-coating the surface of the thus obtained particles with (1) a fine powder of a water-insoluble polymer or (2) a fine powder of a water-insoluble polymer and at least one member selected from the group consisting of talc, magnesium stearate and titanium oxide.

The invention relates to a method for preparing an anti-secondary caries cavity repairing material, which belongs to the field of medical and dental preparations. The prior fluorine-containing anti-secondary caries composite resin caries filling material has the problems of over-quick fluorine dilution, poor interface compatibility and no rigid support to a caries filling body. The method in the invention aims to solve the problems and comprises the following steps: utilizing a silane coupling agent to perform surface modification on nanometer inorganic powder; under a dark condition, uniformly mixing the modified nanometer inorganic powder with monomers of a bisphenol A glycidyl methacrylate class, diluents of a dimethacrylate triethylene-glycol ester class, light triggers of a camphorquinone class, coinitiators of a dimethylamino ethyl methacrylate class and other materials; and removing bubbles under a vacuum condition. The method of the invention has the key point that the nanometer inorganic powder comprises a fluorine-containing zirconium dioxide nanometer tube which takes up 10 to 80 percent of the percent by weight of the nanometer inorganic powder, and the fluorine-containing zirconium dioxide nanometer tube integrates the functions of fluorine slow release of fluorine anti-secondary caries and structure reinforcement.

The invention relates to the field of pharmaceutical preparation, and in particular relates to a bionic lovastatin nano-structured lipid carrier and a preparation method thereof. The method is characterized in that endogenic lipid material is adopted so as to encapsulate medicines in the carrier, so that injection for intravenous injection can be produced. The prepared nano-structured lipid carrier has good biocompatibility and is biodegradable, and toxic and side effects are reduced; the bionic lovastatin nano-structured lipid carrier has small grain size, high dispersity, good stability and can long-lastingly and slowly release medicines; and lovastatin medicines and the bioactive lipid carrier can be combined together so as to achieve a collaborative treatment function, and the curative effect of the medicine in treating cardiovascular disease is increased.

The invention discloses a nanofiber-based biomedical non-woven fabric and a preparation method thereof. Firstly, phase-change temperature-adjusting microcapsules are added into nuclear layer liquid offirst fibers, a large number of hydrophilic groups are introduced into the nuclear layer liquid to prepare fibers A with super-hydrophilic performance, and alkali liquor is used for preparing multiple holes in the surfaces of the fibers A, so that the binding force of the fibers A and antibacterial capsules is increased; and a spinning solution is modified through an electrochemical method, modified ceramic with anti-radiation and anti-bacterial capacity is added, second fibers with super-hydrophobic performance are obtained, and a first non-woven fabric and a second non-woven fabric are bonded through a bonding agent to obtain the biomedical non-woven fabric which has the phase change temperature adjustment capacity, the moisture absorption capacity, the anti-bacterial capacity, the blood repelling capacity and the anti-radiation capacity, while the wearing comfort of medical staff is improved, invasion of microorganisms and pathogens can be effectively resisted, and high practicability is achieved.

The invention relates to a drug release mechanism based fluorine-containing dental restorative material, belonging to the field of dental preparation. The invention aims at solving the problem that the current cavity-filling compound resin materials in the simple fluorine doped salt are fast in fluorine release, poor in interfacial compatibility and have no rigid support for the cavity-filling bodies. The material comprises the following components in percentage by weight: 20-85% of inorganic nanopowder subjected to surface modification by silane coupling agents, 8-70% of resin monomers such as bisphenol A-glycidyl methacrylate, 5-25% of diluents such as triethylene-glycol dimethacrylate, 0.25-2% of photoinitiators such as camphorquinone and 0.5-3% of coinitiators such as dimethylaminoethyl methacrylate. The technical scheme is characterized in that the inorganic nanopowder contains fluorine-carrying zirconia nanotubes which account for 10-80% of the inorganic nanopowder by weight. The fluorine-carrying zirconia nanotubes have the functions of resisting secondary caries by releasing fluorine and reinforcing structures.

The invention discloses a slow-release moisturizing face cream and a preparation method thereof. The face cream is prepared from the following components in percentage by mass of 5-15% of polyhydric alcohol, 1-5% of fatty alcohol, 2% of polydimethylsiloxane, 1-25% of grease, 0.1-10% of a skin-care active ingredient, 0.5-2% of an emulsifier, 0.2-2.8% of a pH regulator, 0.2-1.5% of an antioxidant, 0.2-2% of a thickening agent and the balance of water. The preparation method comprises the following steps of S1, weighing the raw materials; S2, mixing the grease, the fatty alcohol and the emulsifier, mixing a mixture with 30% of the total amount of the skin-care active ingredient, and carrying out heating and stirring until a mixture is dissolved to obtain an oil phase; S3, mixing the polyhydric alcohol, the pH regulator, the antioxidant, the thickening agent and the water, mixing a mixture with 30% of the total amount of the skin-care active ingredient, carrying out stirring until a mixture is completely dispersed, heating to 85 DEG C, and cooling to 80 DEG C after 5 minutes to obtain a water phase; S4, pouring the water phase into the oil phase, carrying out homogenizing, and cooling to 65 DEG C to obtain a dispersed phase; S5, adding silicone oil, and carrying out homogenizing to obtain a fourth mixture; and S6, cooling the fourth mixture to 45 DEG C, adding the remaining skin-care active ingredient, and cooling to 25 DEG C to obtain the face cream.