2results about How to "Long release" patented technology

The present application belongs to the technical field of soil microorganism regulation, and particularly relates to a regulator for promoting the symbiosis of alfalfa and rhizobium and a preparation method thereof. The regulator comprises the following raw materials in parts by weight: eugenol 0.58-1.16 parts, lactobacillus peptide 0.1-0.4 parts, emulsification aid 0.03-0.05 parts, and slow-release agent 0.07 parts. The slow-release agent is used to solve the problems of easy degradation of the antibacterial peptide lactobacillus peptide and easy volatilization of eugenol through a slow-release and emulsification process. The regulator can not only ensure the safe germination of alfalfa seeds, but also selectively inhibit the competing bacteria in the soil, significantly improve the niche competition advantage and symbiotic nitrogen fixation efficiency of the exogenous rhizobium, and has the advantages of high efficiency, environmental protection and long field persistence.

The invention discloses ROS (reactive oxygen species)-responsive macrophage-targeted 4OI-loaded hydrogel microspheres, a microneedle dressing, a preparation method of the ROS-responsive macrophage-targeted 4OI-loaded hydrogel microspheres and the microneedle dressing and novel medical application of the ROS-responsive macrophage-targeted 4OI-loaded hydrogel microspheres and the microneedle dressing in burn wounds, and belongs to the technical According to the adopted scheme, PLGA-TK-PEG-COOH is used as a carrier, 4OI is entrapped through a microemulsion ultrasonic method, and then mannose is connected through an amidation reaction for surface modification. According to the hydrogel microspheres, ROS response accurate drug release is realized by virtue of TK bonds, and advanced leakage of drugs is avoided; mannose can target a macrophage surface receptor, so that the delivery accuracy is improved. The hydrogel has the characteristics of high encapsulation efficiency, high ROS response and release at the diseased region, excellent biocompatibility of the used materials, and simple and controllable preparation process. The 4OI delivery system can be widely applied to treatment of related diseases such as inflammation and tumors, can also be compounded to prepare a microneedle dressing to realize local deep administration, effectively solves the pain points of poor targeting property, large toxic and side effects and the like of the existing 4OI delivery system, and has important clinical application value and industrialization prospect.