Citric acid and chitosan modified biocompatible polyurethane and preparation method thereof

A chitosan modification and biocompatibility technology, applied in the field of biomedical materials, can solve the problems of durability of heparin effect, expensive modification materials, and blood protein pollution on the membrane surface, etc. The effect of improving protein contamination performance, improving anticoagulant performance, and improving chemical stability

Inactive Publication Date: 2015-08-12
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the traditional polyurethane is in direct contact with blood, there are the following problems: the membrane surface is easily polluted by blood proteins, and long-term contact easily leads to the formation of thrombus
However, they have the following disadvantages: the modified materials are expensive and the process is cumbersome, and the use of heparin tends to cause excessive release, which causes the problem of durability of the effect and the problem of blood loss

Method used

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  • Citric acid and chitosan modified biocompatible polyurethane and preparation method thereof
  • Citric acid and chitosan modified biocompatible polyurethane and preparation method thereof
  • Citric acid and chitosan modified biocompatible polyurethane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Add 10 parts (mass, the same below) of diphenylmethane diisocyanate (MDI) and 8 parts of polyethylene glycol (PEG) into a double-necked flask, and then add 42 parts of N,N-dimethylacetamide ( DMAc) solvent and 0.5 parts of stannous octoate catalyst, mechanically stirred until all reactants were dissolved. Under the protection of nitrogen, react at 75°C for 2h to obtain a modified polyurethane precursor (PU). Add 9 parts of citric acid (CA), react at 80°C for 4h; continue to heat up to 85°C for 12h. The product was washed successively with deionized water and absolute ethanol, and dried under constant temperature and vacuum to obtain citric acid-modified polyurethane (CA-PU).

[0035] The above-mentioned citric acid-modified polyurethane (CA-PU) was activated by immersing it in a citric acid buffer solution (pH=4.8) containing 2 mmol / L carbodiimide at 4 °C for 2 h, and then washed with phosphate buffer and deionized water in sequence. , filtered to obtain activated cit...

Embodiment 2

[0037]Add 10 parts (mass, the same below) of diphenylmethane diisocyanate (MDI) and 8 parts of polyethylene glycol (PEG) into a double-necked flask, and then add 60 parts of N,N-dimethylacetamide ( DMAc) solvent and 0.5 parts of stannous octoate catalyst, mechanically stirred until all reactants were dissolved. Under the protection of nitrogen, react at 75°C for 25h to obtain a modified polyurethane precursor (PU). Add 10 parts of citric acid (CA), react at 80°C for 4h; continue to heat up to 85°C for 12h. The product was washed successively with deionized water and absolute ethanol, and dried under constant temperature and vacuum to obtain citric acid-modified polyurethane (CA-PU).

[0038] The above-mentioned citric acid-modified polyurethane (CA-PU) was activated by immersing it in a citric acid buffer solution (pH=4.8) containing 2 mmol / L carbodiimide at 4 °C for 3 h, and then washed with phosphate buffer and deionized water in sequence. , filtered to obtain activated ci...

Embodiment 3

[0040] Add 10 parts (mass, the same below) of diphenylmethane diisocyanate (MDI) and 5 parts of polyethylene glycol (PEG) into a double-necked flask, and then add 42 parts of N,N-dimethylacetamide ( DMAc) solvent and 0.5 parts of stannous octoate catalyst, mechanically stirred until all reactants were dissolved. Under the protection of nitrogen, react at 75°C for 2h to obtain a modified polyurethane precursor (PU). Add 15 parts of citric acid (CA), react at 80°C for 4h; continue to heat up to 85°C for 18h. The product was washed successively with deionized water and absolute ethanol, and dried under constant temperature and vacuum to obtain citric acid-modified polyurethane (CA-PU).

[0041] The above-mentioned citric acid-modified polyurethane (CA-PU) was activated by immersing it in a citric acid buffer solution (pH=4.8) containing 2 mmol / L carbodiimide at 4 °C for 4 h, and then washed with phosphate buffer and deionized water in sequence. , filtered to obtain activated ci...

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Abstract

The invention discloses a citric acid and chitosan modified biocompatible polyurethane and a preparation method thereof. A main chain of the polyurethane disclosed by the invention is a polyurethane long chain, the two ends of the long chain are respectively an anticoagulative citric acid structure covalently grafted with the long chain, and a chitosan structure is selectively grafted on the citric acid structure. The preparation method comprises the following steps: firstly, adding isocyanate, polyethylene glycol and a catalyst into a reactor, and carrying out stirring reaction for 2-5 h in the presence of nitrogen; then, adding a citric acid, and heating for reacting for 12-18 h, so that a citric acid modified polyurethane is obtained; and activating the citric acid modified polyurethane by using carbodiimide, and soaking the obtained object into a chitosan-acetic acid solution to carry out acid-amide condensation reaction, so that the modified biocompatible polyurethane is obtained. According to the citric acid and chitosan modified biocompatible polyurethane disclosed by the invention, the citric acid structures with biocompatibility and the chitosan structure are covalently bonded in the polyurethane long chain, so that the polyurethane has good chemical stability and biocompatibility, and can be used as a biomedical material; and the preparation method has the advantages of simple and easily-controlled process, low cost, and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to biocompatible polyurethane modified by citric acid and chitosan and a preparation method thereof. Background technique [0002] Polyurethane has good wear resistance, elasticity and biocompatibility, and is widely used in the manufacture of various internal and external replacement organs and surface coatings of various catheters and medical materials in interventional operations. However, when conventional polyurethanes are in direct contact with blood, there are problems as follows: the membrane surface is easily polluted by blood proteins, and prolonged contact easily leads to the formation of thrombus. The invention aims to solve the problems of protein adsorption and thrombus generated when the polyurethane material is used, and provides a polyurethane material with good hemocompatibility and biocompatibility and a preparation method thereof. [0003] At present, convent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08G18/83C08G18/48C08J3/24
Inventor 邱运仁吴兴泽吴定宇
Owner CENT SOUTH UNIV
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