39 results about "Blood proteins" patented technology

The invention discloses an abdominal aortic aneurysm progress prediction method and system based on cross-modal knowledge distillation. The method comprises the following steps: collecting blood of a target object; the method comprises the following steps: detecting the concentration of blood protein fingerprint markers of blood of a target object, wherein the blood protein fingerprint markers comprise matrix metalloproteinase-12, calcitonin-related polypeptide-alpha, uromodulin, nerve injury induction protein-1, glycosylated hemoglobin A1c and fibroblast growth factor-9; carrying out abdominal aortic aneurysm risk calculation by calling Student-net of cross-modal knowledge distillation based on the blood protein fingerprint marker concentration; wherein the input of the Teaser-net of the cross-modal knowledge distillation comprises a CTA image feature and a pathological section feature, and a category probability vector output by the Student-net is aligned with a category probability vector output by the Teaser-net; and outputting the risk level of the abdominal aortic aneurysm and the probability of occurrence / progress / rupture of the abdominal aortic aneurysm in the preset year. And the development of the aortic aneurysm disease is accurately predicted.

The invention discloses a blood protein precise active peptide capable of tonifying qi and blood, improving microcirculation and promoting vasodilation and a preparation method and application thereof, and belongs to the technical field of blood protein peptide. The blood protein precision active peptide comprises at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII or FPHFD. The prepared blood protein precision active peptide has multiple biological activities: an antihypertensive effect is achieved by inhibiting ACE and vasoconstriction substances; vasodilation is promoted by activating a PI3K / AKT / eNOS signal channel; a zebra fish model proves that the traditional Chinese medicine composition has the effects of remarkably improving microcirculation and tonifying qi and blood. The preparation method is low in equipment requirement, simple in process, easy to operate and convenient for industrial large-scale production. The method enriches a bioactive peptide library, and is of great significance in promoting technical progress and industrial upgrading in the field of hemoglobulin peptides.

The invention relates to the technical field of tumor markers, in particular to a pancreatic cancer early screening marker combination based on blood protein and application of the pancreatic cancer early screening marker combination. Through proteomics analysis and bioinformatics screening, 12 kinds of proteins such as NME3, HPGDS, CEACAM5, TNFSF12, SCG3, VTCN1, GFRA1, KRT19, TMPRSS12, NELL2, KAZALD and MMP12 are determined to serve as the potential early screening markers of the pancreatic cancer. Researches show that the combination of the proteins can effectively distinguish pancreatic cancer patients from non-pancreatic cancer patients, and has good sensitivity and specificity. A screening model constructed based on the protein combination can be applied to auxiliary diagnosis, risk assessment and population screening of pancreatic cancer, and has important clinical transformation value.

The invention belongs to the technical field of medical nutritional food, and particularly relates to a composite peptide nutritional composition for promoting wound healing and a preparation process and application thereof. The composite peptide nutritional composition for promoting wound healing is prepared from the following preparation raw materials in percentage by weight: 15%-25% of fish collagen peptide, 0.03%-0.05% of cattle spleen peptide, 0.10%-0.30% of blood protein oligopeptide, 0.10%-0.30% of albumin peptide, 0.01%-0.03% of ginseng powder, 15%-20% of a composite fermentation extract, 10%-20% of a plant extract, 20%-25% of prebiotics and the balance of whey protein matrix, totaling 100%. The self-made fish collagen peptide, the compound fermentation extract and other raw materials are adopted, the content of various active ingredients such as healing-promoting peptide fragments and anti-inflammatory repair is increased, the bioavailability of the plant extract is improved through the embedding technology, and therefore the wound healing rate and quality are remarkably improved.

Compounds, systems, kits, methods, and / or apparatuses may be operative to reduce amyloid beta (Aβ) peptide in a patient, including a central nervous system (CNS) of the patient and / or a periphery (non-CNS portion) of the patient. In some embodiments, a displacer fluid comprising a Aβ displacer may be introduced to the patient to bind to a blood protein, such as albumin, that binds Aβ (for instance, Aβ peptide or non-plaque Aβ) in the patient periphery. Binding of the displacer to the blood protein may facilitate more free Aβ peptide (for instance, Aβ monomers) in the periphery for clearance via natural processes, such as through the liver or kidneys, and / or artificial processes, such as dialysis. Increased removal of the free Aβ peptide in the periphery may ultimately lead to less Aβ peptide in the CNS, which may decrease Aβ plaque formation in Alzheimer's Disease (AD) patients. Other embodiments are described.

The invention belongs to the field of biological detection, and particularly relates to a blood protein characteristic polypeptide, a detection kit and application of the blood protein characteristic polypeptide to identification of adulteration and weight gain of hirudo nipponia. And the sequence of the blood protein marker polypeptide is LLGNVIVVVLAR. On the basis of constructing a species marker polypeptide identification method, a heterologous blood protein traceability analysis strategy is introduced, beta globin in blood of common livestock such as pigs, cattle, sheep, horses, donkeys and the like is subjected to multiple sequence alignment, and highly conservative species-independent marker polypeptide is screened out as a chemical marker; and a multi-reaction monitoring (MRM) non-standard quantitative peak area ratio judgment and detection method based on a liquid chromatography-triple quadrupole mass spectrometry technology is established, so that a scientific judgment basis is provided for the problem of blood doping and weight increment.

This application discloses a precise active peptide of hemoglobin with the functions of replenishing qi and blood, improving microcirculation, and promoting vasodilation, as well as its preparation method and application, belonging to the field of hemoglobin peptide technology. The precise active peptide of hemoglobin contains at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII, or FPHFD. The prepared precise active peptide of hemoglobin exhibits multiple biological activities: it exerts a hypotensive effect by inhibiting ACE and vasoconstrictive substances; it promotes vasodilation by activating the PI3K / AKT / eNOS signaling pathway; and it has been shown to significantly improve microcirculation and replenish qi and blood in a zebrafish model. The preparation method has low equipment requirements, is simple and easy to operate, and is suitable for large-scale industrial production. This invention enriches the bioactive peptide library and is of great significance for promoting technological progress and industrial upgrading in the field of hemoglobin peptides.

The application relates to the technical field of blood protein detection, in particular to a blood protein detection kit for early diagnosis of new-onset diabetes and pancreatic cancer, which comprises a kit and test tubes, a water tank is arranged on the upper portion of the kit, a plurality of guide cylinders are arranged in the water tank, the top end of the guide cylinder is provided with a boss mounted on the top wall of the kit, the boss is in communication with the inside of the guide cylinder, and the outer surface of the test tube is provided with flexible spiral leaves and is inserted into the boss and the guide cylinder. Through five core advantages of accurate temperature control, efficient mixed coating, intelligent pollution washing, closed-loop gas path design and structure optimization, the stability, efficiency, precision and convenience of detection are comprehensively improved; the automatic design reduces human errors, the environment-friendly closed-loop design takes into account practicability and safety, and is suitable for the precise detection requirements of early diagnosis of diabetes and pancreatic cancer.

The invention relates to a blood protein peptide composition for improving body type and posture symptoms, and belongs to the field of bioactive peptides. The blood protein peptide composition disclosed by the invention comprises an LMN polypeptide and an LTL polypeptide, the amino acid sequence of the LMN polypeptide is Leuu-Met-Asn; the amino acid sequence of the LTL polypeptide is Leuu-Thr-Leu (Leu-Thr-Leu). The blood protein peptide composition prepared by using the technical scheme of the invention can improve body type and posture symptoms caused by lymphedema, and shows good economic benefits and social benefits.

The present application belongs to the field of food technology, and particularly relates to a qi and blood nourishing compound composition, a preparation method and application thereof. The raw materials of the qi and blood nourishing compound composition include 10-20 parts of red ginseng powder, 5-20 parts of mulberry powder, 5-20 parts of Chinese wolfberry powder, 5-15 parts of tremella polysaccharide, 5-15 parts of blood protein polypeptide and 0.5-2 parts of ferrous gluconate by weight. The composition of the present application promotes the generation of qi and blood, regulates the running of qi and blood, and at the same time enhances the antioxidant and anti-fatigue ability of the body, thereby providing a more effective solution for improving the qi and blood deficiency type sub-health state.

The present application relates to compost fermentation technical field, especially to a kind of compost fermentation device using duck blood protein enzyme.The technical scheme includes: support, jar body and top end top cover rotationally installed on support;Worm, worm wheel are arranged between jar body and support, worm engages worm wheel and one end is provided with hand wheel, can drive jar body rotation angle adjustment.The inner container of jar body is divided into two parts by drain plate;Top cover is provided with motor-driven stirring blade, air inlet pipe and air outlet pipe.The drain valve with elastic plugging element is arranged in the drain outlet of jar body bottom;It is also provided with air pressure control mechanism, including pressure valve on top cover and adjusting valve on air outlet pipe, can be raised by switching adjusting valve state The air pressure in jar, realize air pressure auxiliary drainage.The present application is through angle-adjustable jar body, stirring mixing, air pressure auxiliary drainage and ventilation heat preservation and other structures synergies, make duck blood protein enzyme and material fully contact, maintain stable fermentation environment, realize efficient enzymatic fermentation and percolate convenient discharge, improve compost efficiency and quality, reduce operating intensity.

The invention belongs to the technical field of food, and particularly relates to a qi-reinforcing and blood-nourishing compound composition as well as a preparation method and application thereof. The compound composition for reinforcing qi and nourishing blood comprises the following raw materials in parts by weight: 10-20 parts of red ginseng powder, 5-20 parts of mulberry powder, 5-20 parts of Chinese wolfberry fruit powder, 5-15 parts of tremella polysaccharide, 5-15 parts of blood protein polypeptide and 0.5-2 parts of ferrous gluconate. The composition provided by the invention provides a more effective solution for improving the qi-blood deficiency type sub-health status by promoting the generation of qi and blood, regulating the running of qi and blood and enhancing the self anti-oxidation and anti-fatigue capabilities at the same time.

The invention provides a protein data analysis and processing method and system and a server, and relates to the field of protein data analysis and processing, the scheme realizes a standardized and automatic analysis process, and the whole process from original mass spectrum data import, database searching and matching, quantitative analysis, annotation enrichment, visual display to report generation is automatically completed, so that the analysis efficiency is improved. An efficient closed-loop analysis system of'delivery after off-machine 'is realized, and the efficiency, depth and stability of blood protein data processing are remarkably improved.

The application belongs to the technical field of food, and particularly relates to a blood protein oligopeptide solid beverage and a preparation method and application thereof. The blood protein oligopeptide solid beverage is mainly prepared from the following components by weight: 30-50 parts of blood protein oligopeptide; 15-25 parts of resistant dextrin and ferrous lactate complex; 20-30 parts of pH and enzyme double-response microsphere carrier; 8-12 parts of sea buckthorn fruit powder and vitamin C liposome; 15-25 parts of collagen peptide; and 0.5-1 part of silicon dioxide. The pH and enzyme double-response microsphere carrier is mainly composed of chitosan, pectin and trypsin cut polypeptide. The collagen peptide, blood protein oligopeptide and pH and enzyme double-response microsphere carrier are used to prepare microspheres. The blood protein oligopeptide is prepared by a fermentation method, and the pH and enzyme double-response microsphere carrier method is combined, so that the iron absorption rate and the stability of active ingredients are significantly improved.

The utility model provides a kind of oscillation device for blood protein detection, it is related to blood protein detection field, including oscillation unit, including the oscillation generation box for generating oscillation movement, the cover fixedly connected in the top of the oscillation generation box, the spring fixedly connected in the bottom of the inner chamber of the cover four around, the oscillation platform fixedly connected in the top of the spring, and the tube groove for limiting placement test tube being opened in the top of the oscillation platform;The utility model is through the design of limiting component, especially the cooperation of screw rod, pressing plate, pad and rubber pad, can effectively close and limit the top of test tube, prevent blood leakage due to oscillation force and liquid inertia in the process of oscillation, to avoid sample waste and experimental environment pollution, by the cooperation of the oscillation generation box in oscillation unit, oscillation platform and spring, can make oscillation more stable and uniform, help to improve the mixing effect of blood sample, ensure the accuracy and reliability of detection result.

This invention provides a low-temperature storage device for blood protein detection, relating to the field of blood protein detection. It includes a storage unit comprising a cabinet, six storage cavities located on the front of the cabinet, a placement platform movably connected to the inner cavity of each storage cavity, and a test tube slot located on the top of the placement platform for positioning and placing sample tubes. This invention designs six independent storage cavities, each with its own placement platform, capable of holding different types of blood protein samples. Personnel can differentiate and control the temperature according to the sample's needs, facilitating later retrieval and preventing the uniform internal temperature problem caused by a monolithic design, thus improving storage efficiency. Furthermore, a microcontroller can independently control the operating state of the corresponding semiconductor cooling chip based on temperature information from the temperature sensor in each storage cavity, achieving precise temperature control and meeting the diverse storage temperature requirements of different blood protein samples.

The present application relates to the field of beverage technology and specifically discloses a blood protein polypeptide beverage that increases oxygen carrying capacity. The blood protein polypeptide beverage that increases oxygen carrying capacity is mainly made from the following raw materials: blood protein polypeptide microcapsule powder, red date extract, rhodiola rosea powder, red ginseng powder, acerola cherry powder, honeysuckle pollen, collagen peptide powder, taurine, vitamins, acidulant, sweetener, compound thickener, and water; the blood protein polypeptide microcapsule powder is mainly made from the following raw materials: blood protein polypeptide powder, maltitol, modified starch, phospholipids, water, mono- and diglycerol fatty acid esters, 1,3-acetone dicarboxylic acid, and an organic solvent. This blood protein polypeptide beverage that increases oxygen carrying capacity has the advantages of good blood-tonifying effect, high absorption rate, and high safety. It can effectively improve the body's anemia indicators and enhance erythropoiesis.

The invention relates to the technical field of blood protein detection, in particular to a blood protein detection kit for early diagnosis of new diabetes pancreatic cancer, which comprises a kit and a test tube, a water tank is arranged at the upper part in the kit, a plurality of guide cylinders are arranged in the water tank, the top ends of the guide cylinders are provided with bosses mounted on the top wall of the kit, and the test tube is arranged on the test tube. The boss is communicated with the interior of the guide cylinder, and a flexible spiral blade is arranged on the outer surface of the test tube and is inserted into the boss and the guide cylinder. According to the invention, through five core advantages of accurate temperature control, efficient mixed coating, intelligent pollution discharge washing, closed-loop gas circuit design and structure optimization, the stability, efficiency, precision and convenience of detection are comprehensively improved; the automatic design reduces personal errors, the environment-friendly closed-loop design gives consideration to practicability and safety, and the system is suitable for accurate detection requirements of early diagnosis of diabetic pancreatic cancer.

The invention belongs to the technical field of food, and particularly relates to a blood protein oligopeptide solid beverage as well as a preparation method and application thereof. The composition is mainly prepared from the following components in parts by weight: 30-50 parts of blood protein oligopeptide; 15-25 parts of a resistant dextrin and ferrous lactate compound; 20 to 30 parts of a pH and enzyme dual-response microsphere carrier; 8-12 parts of sea buckthorn fruit powder and vitamin C liposome; 15 to 25 parts of collagen peptide; 0.5 to 1 part of silicon dioxide; the pH and enzyme dual-response microsphere carrier is mainly prepared from chitosan, pectin and trypsin cut polypeptide; the collagen peptide, the blood protein oligopeptide and the pH and enzyme double-response microsphere carrier are prepared into microspheres. The blood protein oligopeptide is prepared through a fermentation method, and a pH and enzyme double-response microsphere carrier method is combined, so that the iron absorption rate and the stability of active ingredients are remarkably improved.

The invention discloses a pet nutritional composition capable of reducing peculiar smell of excrements and a preparation method of the pet nutritional composition. The pet nutritional composition is prepared by the following steps: performing pre-emulsification and high-shear emulsification on functional components such as ethyl lactate, pig blood protein peptide, a pericarpium citri reticulatae extract, a yucca extract and phytic acid; the microcapsule is encapsulated in a sodium alginate-calcium chloride gel network integrated with nano zeolite powder and agaro-oligosaccharide through ionic gelation to form a functional microcapsule base material; meanwhile, the lactobacillus is embedded in the sodium alginate-chitosan composite gel microcapsule by adopting an emulsification-internal gelation technology. And finally, mixing the prebiotics with mannan oligosaccharide and fructo-oligosaccharide compounded prebiotics. Through split type embedding and differentiated wall material design, the problems that probiotics are prone to inactivation and components interfere with one another are solved, intestinal tract targeted rapid release of functional components and sequential precise delivery of the probiotics are achieved, a triple deodorization mechanism of source inhibition, efficient adsorption and micro-ecological regulation is synergistically exerted, and the deodorization effect is good. The deodorization efficiency and the action durability are obviously improved.

The invention provides a biomarker combination for detecting brain functional diseases. The biomarker combination comprises four protein markers, namely a glial fibrillary acidic protein (GFAP), an interleukin-6 (IL-6), an interleukin-1beta (IL-1beta) and a tumor necrosis factor alpha (TNF-alpha). The combined detection sensitivity of GFAP, IL-6, IL-1beta and TNF-alpha in a training column set can reach 85.26%, the specificity can reach 88.04%, and the area (AUC) under an ROC curve can reach 0.866. When the blood protein marker combination is used for preparing a reagent for detecting and evaluating the brain function of a patient, the disease diagnosis sensitivity can be improved, and the blood protein marker combination has the advantages of high specificity, good stability, rapid detection and the like. The biomarker combination disclosed by the invention can be applied to products for disease risk prediction, screening, prognosis evaluation, treatment effect monitoring or relapse monitoring and the like of brain function related diseases.

The invention relates to an aquatic feed additive for resisting nocardia infection and a preparation method thereof, and belongs to the technical field of aquaculture, the aquatic feed additive comprises 2-8% by weight of polypeptide, and the polypeptide has an amino acid sequence as shown in SEQ ID NO: 1. According to the application, the efficient, safe and sustainable nocardia-resistant feed additive is successfully developed by using the polypeptide derived from fish blood protein enzymolysis, an ideal alternative scheme is provided for solving intractable bacterial infection in aquaculture, and the nocardia-resistant feed additive has remarkable economic benefits and ecological benefits.

1. The name of the product of this design: Packaging box (blood protein oligopeptide Codonopsis pilosula and Astragalus paste plant beverage). 2. Purpose of this design product: used as outer packaging box for articles. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: main view.

The invention relates to the technical field of blood protein polypeptides, in particular to a pig blood polypeptide with an effect of relieving myelosuppression as well as a preparation method and application of the pig blood polypeptide. The preparation method of the pig blood polypeptide comprises the following steps: carrying out enzymolysis on a mixture of pig blood globulin powder and water at 50-60 DEG C under the action of enzyme for 2-8 hours, and carrying out enzyme deactivation treatment; the enzyme comprises at least one of alkaline protease, papain and neutral protease. According to the preparation method of the pig blood polypeptide, the spray-dried blood cells are used as a raw material to prepare the pig blood polypeptide, so that the dependence of a traditional process on fresh pig blood is broken through, and secondary high-value utilization of the spray-dried blood cells is realized; the pig blood polypeptide provided by the invention can be used for relieving the myelosuppression effect induced by 5-FU.

The application discloses a kind of abdominal aortic aneurysm progression prediction method and system based on cross-modal knowledge distillation, by collecting the blood of target object;The blood of target object is detected by blood protein fingerprint marker concentration, and blood protein fingerprint marker includes matrix metalloproteinase-12, calcitonin related polypeptide-alpha, urine regulator, nerve injury induced protein-1, glycosylated hemoglobin A1c, fibroblast growth factor-9;Based on blood protein fingerprint marker concentration, Student-net of cross-modal knowledge distillation is called to calculate abdominal aortic aneurysm risk;Wherein, the input of Teacher-net of cross-modal knowledge distillation includes CTA image feature and pathological section feature, and the category probability vector output by Student-net is aligned with the category probability vector output by Teacher-net;Output abdominal aortic aneurysm risk grade and preset year abdominal aortic aneurysm occurrence / progression / rupture three event probability.Precise prediction is carried out to the development of aortic aneurysm disease.

The utility model discloses an automatic bottle arranging and collecting machine which comprises a clamping conveying device, an arranging conveying device, a buffering box and a stop positioning device. The clamping and conveying device is installed in the clean workshop, the output end of the clamping and conveying device extends out of the clean workshop, and the conveying direction of the clamping and conveying device is perpendicular to the conveying direction of the arranging and conveying device. An arranging and conveying device is installed outside the clean workshop, the arranging and conveying device is located beside the clamping and conveying device, the arranging and conveying device comprises a first conveying belt body, a second conveying belt body, a driving roller, a driven roller, a roller rotation driving mechanism, a first installation frame and a second installation frame, and the first conveying belt body and the second conveying belt body are parallel to each other; the first conveying belt body and the second conveying belt body surround the driving roller and the driven roller. The automatic arranging and bottle collecting machine solves the problem that in the prior art, blood protein bottles produced in a clean workshop cannot be arranged and cached in rows after being output.

The invention belongs to the technical field of in-vitro diagnosis, and particularly relates to a sample diluent as well as a preparation method, application and a product thereof. The invention provides a sample diluent. The sample diluent is composed of a stabilizer, glucose, poloxamer, a nonionic surfactant, a biological preservative, a metal ion salt and a buffer solution. The sample diluent provided by the invention can effectively solve the problems of high background, poor detection specificity, low stability and the like caused by binding of EDTA and quantum dot divalent metal ions in an EDTA anticoagulant plasma sample, and the detection sensitivity and specificity are remarkably improved. The sample diluent is suitable for preparing Alzheimer's disease diagnostic reagents, kits or chips, can accurately detect beta amyloid protein, phosphorylated Tau protein, blood protein and other markers in plasma, is especially suitable for EDTA anticoagulant plasma sample detection, and provides reliable basis for clinical diagnosis.

The present invention provides a drying and collecting device for blood protein powder, which relates to the field of pig blood powder production. The drying and collecting device for blood protein powder includes a main shell, an air heating structure, an atomizing structure, and a feeding mechanism. A first hot air port, a second hot air port, and a spray head are provided in the inner cavity of the main shell; the first hot air port and the second hot air port are respectively arranged on opposite side walls of the main shell, and the airflow direction of the first hot air port is parallel to the airflow direction of the second hot air port and is staggered to form a vortex airflow zone in the inner cavity of the main shell; the spray head is arranged at one axial end of the vortex airflow zone, and the main shell is also provided with a discharge port located at the other axial end of the vortex airflow zone, and the feeding mechanism is installed at the discharge port. The mist enters the vortex airflow zone and is fully contacted and mixed with the hot air. The mist generates a synchronous vortex motion as the hot air moves, which prolongs the heating time of the mist in the inner cavity of the main shell, resulting in a good drying effect and higher powder production efficiency.

The invention relates to a composite peptide nutritional composition as well as a preparation method and application thereof, and belongs to the technical field of functional foods. The composite peptide nutritional composition comprises a hematopoietic function regulating system (such as cattle spleen peptide, blood protein polypeptide and salmon hydrolyzed protein peptide), an iron metabolism balance regulating system (concentrated hawthorn clear juice) and a nutrition absorption promoting system (endothelium corneum gigeriae galli peptide and pericarpium citri reticulatae powder) which have a synergistic effect. The traditional Chinese medicine composition does not contain an exogenous iron agent, and aims to improve malnutrition caused by chronic hemolytic diseases such as thalassemia. The uniformity and the stability of the product are guaranteed through a specific proportioning and a staged mixing preparation process. Animal experiments show that the composition can significantly improve hemoglobin and red blood cell count of beta-thalassemia model mice, effectively control serum iron and liver iron accumulation levels of the mice, show unique advantages of efficient hematopoiesis and low iron accumulation, and has broad application prospects. And a new nutrition support scheme is provided for improving anemia and abnormal iron metabolism conditions caused by chronic hemolysis.

The invention discloses rhizoma polygonati blood protein polypeptide oral liquid as well as a preparation method and application thereof, and relates to the technical field of functional food. The health-care beverage is prepared from the following raw materials in parts by weight: 10-25 parts of a rhizoma polygonati extract, 5-15 parts of blood protein polypeptide, 3-10 parts of a fructus lycii extract, 2-8 parts of a red date extract, 1-5 parts of honey and 50-80 parts of purified water. The rhizoma polygonati extract is prepared through the following steps that fresh rhizoma polygonati is cleaned and sliced, then a 70%-80% ethanol solution with the mass 3-5 times that of the rhizoma polygonati is added, reflux extraction is conducted 2-3 times at the temperature of 50-65 DEG C, each time of reflux extraction lasts for 1.5-2.5 h, extracting solutions are combined, vacuum concentration is conducted till no alcohol smell exists, and the rhizoma polygonati extract is obtained. According to the application, the rhizoma polygonati extract, the fructus lycii extract, the red date extract and the blood protein polypeptide with specific molecular weight are compounded, so that the combined action of plant nourishing ingredients and animal-derived nutritional ingredients is realized, polygonatum sibiricum polysaccharide in the polygonatum sibiricum extract, lycium barbarum polysaccharide in the lycium barbarum extract and red date polysaccharide in the red date extract can jointly regulate the immune function and relieve physical fatigue.