22 results about "Blood proteins" patented technology

The invention discloses a blood protein precise active peptide capable of tonifying qi and blood, improving microcirculation and promoting vasodilation and a preparation method and application thereof, and belongs to the technical field of blood protein peptide. The blood protein precision active peptide comprises at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII or FPHFD. The prepared blood protein precision active peptide has multiple biological activities: an antihypertensive effect is achieved by inhibiting ACE and vasoconstriction substances; vasodilation is promoted by activating a PI3K / AKT / eNOS signal channel; a zebra fish model proves that the traditional Chinese medicine composition has the effects of remarkably improving microcirculation and tonifying qi and blood. The preparation method is low in equipment requirement, simple in process, easy to operate and convenient for industrial large-scale production. The method enriches a bioactive peptide library, and is of great significance in promoting technical progress and industrial upgrading in the field of hemoglobulin peptides.

Compounds, systems, kits, methods, and / or apparatuses may be operative to reduce amyloid beta (Aβ) peptide in a patient, including a central nervous system (CNS) of the patient and / or a periphery (non-CNS portion) of the patient. In some embodiments, a displacer fluid comprising a Aβ displacer may be introduced to the patient to bind to a blood protein, such as albumin, that binds Aβ (for instance, Aβ peptide or non-plaque Aβ) in the patient periphery. Binding of the displacer to the blood protein may facilitate more free Aβ peptide (for instance, Aβ monomers) in the periphery for clearance via natural processes, such as through the liver or kidneys, and / or artificial processes, such as dialysis. Increased removal of the free Aβ peptide in the periphery may ultimately lead to less Aβ peptide in the CNS, which may decrease Aβ plaque formation in Alzheimer's Disease (AD) patients. Other embodiments are described.

The invention belongs to the field of biological detection, and particularly relates to a blood protein characteristic polypeptide, a detection kit and application of the blood protein characteristic polypeptide to identification of adulteration and weight gain of hirudo nipponia. And the sequence of the blood protein marker polypeptide is LLGNVIVVVLAR. On the basis of constructing a species marker polypeptide identification method, a heterologous blood protein traceability analysis strategy is introduced, beta globin in blood of common livestock such as pigs, cattle, sheep, horses, donkeys and the like is subjected to multiple sequence alignment, and highly conservative species-independent marker polypeptide is screened out as a chemical marker; and a multi-reaction monitoring (MRM) non-standard quantitative peak area ratio judgment and detection method based on a liquid chromatography-triple quadrupole mass spectrometry technology is established, so that a scientific judgment basis is provided for the problem of blood doping and weight increment.

This application discloses a precise active peptide of hemoglobin with the functions of replenishing qi and blood, improving microcirculation, and promoting vasodilation, as well as its preparation method and application, belonging to the field of hemoglobin peptide technology. The precise active peptide of hemoglobin contains at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII, or FPHFD. The prepared precise active peptide of hemoglobin exhibits multiple biological activities: it exerts a hypotensive effect by inhibiting ACE and vasoconstrictive substances; it promotes vasodilation by activating the PI3K / AKT / eNOS signaling pathway; and it has been shown to significantly improve microcirculation and replenish qi and blood in a zebrafish model. The preparation method has low equipment requirements, is simple and easy to operate, and is suitable for large-scale industrial production. This invention enriches the bioactive peptide library and is of great significance for promoting technological progress and industrial upgrading in the field of hemoglobin peptides.

The application relates to the technical field of blood protein detection, in particular to a blood protein detection kit for early diagnosis of new-onset diabetes and pancreatic cancer, which comprises a kit and test tubes, a water tank is arranged on the upper portion of the kit, a plurality of guide cylinders are arranged in the water tank, the top end of the guide cylinder is provided with a boss mounted on the top wall of the kit, the boss is in communication with the inside of the guide cylinder, and the outer surface of the test tube is provided with flexible spiral leaves and is inserted into the boss and the guide cylinder. Through five core advantages of accurate temperature control, efficient mixed coating, intelligent pollution washing, closed-loop gas path design and structure optimization, the stability, efficiency, precision and convenience of detection are comprehensively improved; the automatic design reduces human errors, the environment-friendly closed-loop design takes into account practicability and safety, and is suitable for the precise detection requirements of early diagnosis of diabetes and pancreatic cancer.

The present application belongs to the field of food technology, and particularly relates to a qi and blood nourishing compound composition, a preparation method and application thereof. The raw materials of the qi and blood nourishing compound composition include 10-20 parts of red ginseng powder, 5-20 parts of mulberry powder, 5-20 parts of Chinese wolfberry powder, 5-15 parts of tremella polysaccharide, 5-15 parts of blood protein polypeptide and 0.5-2 parts of ferrous gluconate by weight. The composition of the present application promotes the generation of qi and blood, regulates the running of qi and blood, and at the same time enhances the antioxidant and anti-fatigue ability of the body, thereby providing a more effective solution for improving the qi and blood deficiency type sub-health state.

The present application relates to compost fermentation technical field, especially to a kind of compost fermentation device using duck blood protein enzyme.The technical scheme includes: support, jar body and top end top cover rotationally installed on support;Worm, worm wheel are arranged between jar body and support, worm engages worm wheel and one end is provided with hand wheel, can drive jar body rotation angle adjustment.The inner container of jar body is divided into two parts by drain plate;Top cover is provided with motor-driven stirring blade, air inlet pipe and air outlet pipe.The drain valve with elastic plugging element is arranged in the drain outlet of jar body bottom;It is also provided with air pressure control mechanism, including pressure valve on top cover and adjusting valve on air outlet pipe, can be raised by switching adjusting valve state The air pressure in jar, realize air pressure auxiliary drainage.The present application is through angle-adjustable jar body, stirring mixing, air pressure auxiliary drainage and ventilation heat preservation and other structures synergies, make duck blood protein enzyme and material fully contact, maintain stable fermentation environment, realize efficient enzymatic fermentation and percolate convenient discharge, improve compost efficiency and quality, reduce operating intensity.

The invention provides a protein data analysis and processing method and system and a server, and relates to the field of protein data analysis and processing, the scheme realizes a standardized and automatic analysis process, and the whole process from original mass spectrum data import, database searching and matching, quantitative analysis, annotation enrichment, visual display to report generation is automatically completed, so that the analysis efficiency is improved. An efficient closed-loop analysis system of'delivery after off-machine 'is realized, and the efficiency, depth and stability of blood protein data processing are remarkably improved.

The application belongs to the technical field of food, and particularly relates to a blood protein oligopeptide solid beverage and a preparation method and application thereof. The blood protein oligopeptide solid beverage is mainly prepared from the following components by weight: 30-50 parts of blood protein oligopeptide; 15-25 parts of resistant dextrin and ferrous lactate complex; 20-30 parts of pH and enzyme double-response microsphere carrier; 8-12 parts of sea buckthorn fruit powder and vitamin C liposome; 15-25 parts of collagen peptide; and 0.5-1 part of silicon dioxide. The pH and enzyme double-response microsphere carrier is mainly composed of chitosan, pectin and trypsin cut polypeptide. The collagen peptide, blood protein oligopeptide and pH and enzyme double-response microsphere carrier are used to prepare microspheres. The blood protein oligopeptide is prepared by a fermentation method, and the pH and enzyme double-response microsphere carrier method is combined, so that the iron absorption rate and the stability of active ingredients are significantly improved.

The utility model provides a kind of oscillation device for blood protein detection, it is related to blood protein detection field, including oscillation unit, including the oscillation generation box for generating oscillation movement, the cover fixedly connected in the top of the oscillation generation box, the spring fixedly connected in the bottom of the inner chamber of the cover four around, the oscillation platform fixedly connected in the top of the spring, and the tube groove for limiting placement test tube being opened in the top of the oscillation platform;The utility model is through the design of limiting component, especially the cooperation of screw rod, pressing plate, pad and rubber pad, can effectively close and limit the top of test tube, prevent blood leakage due to oscillation force and liquid inertia in the process of oscillation, to avoid sample waste and experimental environment pollution, by the cooperation of the oscillation generation box in oscillation unit, oscillation platform and spring, can make oscillation more stable and uniform, help to improve the mixing effect of blood sample, ensure the accuracy and reliability of detection result.

This invention provides a low-temperature storage device for blood protein detection, relating to the field of blood protein detection. It includes a storage unit comprising a cabinet, six storage cavities located on the front of the cabinet, a placement platform movably connected to the inner cavity of each storage cavity, and a test tube slot located on the top of the placement platform for positioning and placing sample tubes. This invention designs six independent storage cavities, each with its own placement platform, capable of holding different types of blood protein samples. Personnel can differentiate and control the temperature according to the sample's needs, facilitating later retrieval and preventing the uniform internal temperature problem caused by a monolithic design, thus improving storage efficiency. Furthermore, a microcontroller can independently control the operating state of the corresponding semiconductor cooling chip based on temperature information from the temperature sensor in each storage cavity, achieving precise temperature control and meeting the diverse storage temperature requirements of different blood protein samples.

The invention relates to the technical field of blood protein detection, in particular to a blood protein detection kit for early diagnosis of new diabetes pancreatic cancer, which comprises a kit and a test tube, a water tank is arranged at the upper part in the kit, a plurality of guide cylinders are arranged in the water tank, the top ends of the guide cylinders are provided with bosses mounted on the top wall of the kit, and the test tube is arranged on the test tube. The boss is communicated with the interior of the guide cylinder, and a flexible spiral blade is arranged on the outer surface of the test tube and is inserted into the boss and the guide cylinder. According to the invention, through five core advantages of accurate temperature control, efficient mixed coating, intelligent pollution discharge washing, closed-loop gas circuit design and structure optimization, the stability, efficiency, precision and convenience of detection are comprehensively improved; the automatic design reduces personal errors, the environment-friendly closed-loop design gives consideration to practicability and safety, and the system is suitable for accurate detection requirements of early diagnosis of diabetic pancreatic cancer.

The invention discloses a pet nutritional composition capable of reducing peculiar smell of excrements and a preparation method of the pet nutritional composition. The pet nutritional composition is prepared by the following steps: performing pre-emulsification and high-shear emulsification on functional components such as ethyl lactate, pig blood protein peptide, a pericarpium citri reticulatae extract, a yucca extract and phytic acid; the microcapsule is encapsulated in a sodium alginate-calcium chloride gel network integrated with nano zeolite powder and agaro-oligosaccharide through ionic gelation to form a functional microcapsule base material; meanwhile, the lactobacillus is embedded in the sodium alginate-chitosan composite gel microcapsule by adopting an emulsification-internal gelation technology. And finally, mixing the prebiotics with mannan oligosaccharide and fructo-oligosaccharide compounded prebiotics. Through split type embedding and differentiated wall material design, the problems that probiotics are prone to inactivation and components interfere with one another are solved, intestinal tract targeted rapid release of functional components and sequential precise delivery of the probiotics are achieved, a triple deodorization mechanism of source inhibition, efficient adsorption and micro-ecological regulation is synergistically exerted, and the deodorization effect is good. The deodorization efficiency and the action durability are obviously improved.

The invention relates to an aquatic feed additive for resisting nocardia infection and a preparation method thereof, and belongs to the technical field of aquaculture, the aquatic feed additive comprises 2-8% by weight of polypeptide, and the polypeptide has an amino acid sequence as shown in SEQ ID NO: 1. According to the application, the efficient, safe and sustainable nocardia-resistant feed additive is successfully developed by using the polypeptide derived from fish blood protein enzymolysis, an ideal alternative scheme is provided for solving intractable bacterial infection in aquaculture, and the nocardia-resistant feed additive has remarkable economic benefits and ecological benefits.

The invention belongs to the technical field of in-vitro diagnosis, and particularly relates to a sample diluent as well as a preparation method, application and a product thereof. The invention provides a sample diluent. The sample diluent is composed of a stabilizer, glucose, poloxamer, a nonionic surfactant, a biological preservative, a metal ion salt and a buffer solution. The sample diluent provided by the invention can effectively solve the problems of high background, poor detection specificity, low stability and the like caused by binding of EDTA and quantum dot divalent metal ions in an EDTA anticoagulant plasma sample, and the detection sensitivity and specificity are remarkably improved. The sample diluent is suitable for preparing Alzheimer's disease diagnostic reagents, kits or chips, can accurately detect beta amyloid protein, phosphorylated Tau protein, blood protein and other markers in plasma, is especially suitable for EDTA anticoagulant plasma sample detection, and provides reliable basis for clinical diagnosis.

The invention relates to a composite peptide nutritional composition as well as a preparation method and application thereof, and belongs to the technical field of functional foods. The composite peptide nutritional composition comprises a hematopoietic function regulating system (such as cattle spleen peptide, blood protein polypeptide and salmon hydrolyzed protein peptide), an iron metabolism balance regulating system (concentrated hawthorn clear juice) and a nutrition absorption promoting system (endothelium corneum gigeriae galli peptide and pericarpium citri reticulatae powder) which have a synergistic effect. The traditional Chinese medicine composition does not contain an exogenous iron agent, and aims to improve malnutrition caused by chronic hemolytic diseases such as thalassemia. The uniformity and the stability of the product are guaranteed through a specific proportioning and a staged mixing preparation process. Animal experiments show that the composition can significantly improve hemoglobin and red blood cell count of beta-thalassemia model mice, effectively control serum iron and liver iron accumulation levels of the mice, show unique advantages of efficient hematopoiesis and low iron accumulation, and has broad application prospects. And a new nutrition support scheme is provided for improving anemia and abnormal iron metabolism conditions caused by chronic hemolysis.

The invention discloses rhizoma polygonati blood protein polypeptide oral liquid as well as a preparation method and application thereof, and relates to the technical field of functional food. The health-care beverage is prepared from the following raw materials in parts by weight: 10-25 parts of a rhizoma polygonati extract, 5-15 parts of blood protein polypeptide, 3-10 parts of a fructus lycii extract, 2-8 parts of a red date extract, 1-5 parts of honey and 50-80 parts of purified water. The rhizoma polygonati extract is prepared through the following steps that fresh rhizoma polygonati is cleaned and sliced, then a 70%-80% ethanol solution with the mass 3-5 times that of the rhizoma polygonati is added, reflux extraction is conducted 2-3 times at the temperature of 50-65 DEG C, each time of reflux extraction lasts for 1.5-2.5 h, extracting solutions are combined, vacuum concentration is conducted till no alcohol smell exists, and the rhizoma polygonati extract is obtained. According to the application, the rhizoma polygonati extract, the fructus lycii extract, the red date extract and the blood protein polypeptide with specific molecular weight are compounded, so that the combined action of plant nourishing ingredients and animal-derived nutritional ingredients is realized, polygonatum sibiricum polysaccharide in the polygonatum sibiricum extract, lycium barbarum polysaccharide in the lycium barbarum extract and red date polysaccharide in the red date extract can jointly regulate the immune function and relieve physical fatigue.

The invention belongs to the technical field of biological peptide extraction, and particularly discloses blood protein polypeptide as well as a preparation method and application thereof. Comprising the following steps: S1, collecting fresh animal blood, adding a sodium citrate solution, centrifuging, discarding plasma, and collecting blood cells; s2, adding the blood cells obtained in the step S1 into purified water, performing uniform mixing, adjusting the pH value to be acidic, adding papain, performing first enzymolysis, after enzymolysis is finished, performing heating for enzyme deactivation, performing centrifugation, and taking supernate, so as to obtain enzymatic hydrolysate; and S3, adjusting the pH value of the enzymatic hydrolysate obtained in S2 to be alkaline, adding alkaline protease, carrying out secondary enzymolysis, and after the enzymolysis is finished, carrying out heating enzyme deactivation, centrifugation, sediment discarding, ultrafiltration, centrifugation, supernatant taking and freeze-drying to obtain the blood protein polypeptide. The invention discloses a blood protein polypeptide as well as a preparation method and application thereof. The blood protein polypeptide is applied to food or health care products and can effectively improve anemia and recover the number of red blood cells.

The invention relates to the field of biotechnology and food, in particular to deep-sea bacillus amyloliquefaciens Y0902, protease thereof, a preparation method and application of the deep-sea bacillus amyloliquefaciens Y0902 in the field of functional active peptide preparation. The preservation number of the bacillus amyloliquefaciens Y0902 provided by the invention is CCTCC (China Center for Type Culture Collection) NO: M 20252209, and the preservation number of the bacillus amyloliquefaciens Y0902 provided by the invention is CCTCC NO: M 20252209. The invention also provides an application method for producing protease by using the protease-producing strain and preparing various functional active peptides such as collagen peptide, blood protein peptide, chlorella peptide and the like. Compared with the prior art, the strain for producing protease is derived from deep sea cold spring and has the characteristics of pressure resistance, salt resistance and the like; the fermentation method is simple, the enzyme production cost is low, the potential of large-scale production and application is achieved, and particularly the potential application prospect is achieved in the field of functional active peptide preparation.

The application relates to a blood protein peptide for promoting hair follicle reconstruction and application thereof, and belongs to the technical field of bioactive peptides. The blood protein peptide disclosed by the application is selected from one or more of MLL peptide segments and WDL peptide segments; the amino acid sequence of the MLL peptide segment is methionine-leucine-leucine; and the amino acid sequence of the WDL peptide segment is tryptophan-aspartic acid-leucine. The application also provides a preparation method of the blood protein peptide and application of the blood protein peptide in hair follicle reconstruction. The blood protein peptide prepared by using the technical scheme of the application can significantly improve local blood supply around hair follicles, and has a wide application prospect in the field of treating alopecia.

The application relates to a blood protein peptide composition for improving body shape and body posture symptoms, and belongs to the field of bioactive peptides. The blood protein peptide composition disclosed by the application comprises an LMN polypeptide and an LTL polypeptide; the amino acid sequence of the LMN polypeptide is Leu-Met-Asn; and the amino acid sequence of the LTL polypeptide is Leu-Thr-Leu. The blood protein peptide composition prepared by using the technical scheme of the application can improve the body shape and body posture symptoms caused by lymphedema, and good economic benefits and social benefits are exhibited.