Stability-enhanced compound antibacterial coating as well as preparation method and application thereof

A compound antibacterial and stability technology, applied in the field of antibacterial, can solve the problems such as the antibacterial coating that has not yet been known, and achieve the effect of excellent stability and excellent antibacterial performance.

Active Publication Date: 2018-04-13
SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Within the scope of the inventor's knowledge, there is no known report of an antibacterial coating that can meet the above requirements

Method used

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  • Stability-enhanced compound antibacterial coating as well as preparation method and application thereof
  • Stability-enhanced compound antibacterial coating as well as preparation method and application thereof
  • Stability-enhanced compound antibacterial coating as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The collagen substrate is soaked in an acidic aqueous solution of chitosan with a molecular weight of 200,000, and the concentration of chitosan is 5 mg / ml. After soaking for 4 hours, the substrate was taken out, fully washed with deionized water, and the physically adsorbed chitosan was washed away, and after drying under vacuum conditions, the first layer of chitosan coating was constructed on the collagen substrate. Its SEM picture is as follows figure 2 As shown, the SEM of the collagen substrate as figure 1 shown. figure 1 The collagen fiber bundles in the middle are loose and porous, with obvious three-dimensional effect; while figure 2 Due to the deposition and wrapping of CS in the medium collagen fiber bundles, the collagen fiber bundles are bonded together, making the collagen fiber bundles relatively figure 1 Flattened, it can be inferred that a chitosan coating was built on the collagen substrate.

Embodiment 2

[0040] Preparation of nano-silver: according to the molar concentration ratio of 5:1, place azlactone and dopamine in dimethyl sulfoxide, and react at 110°C for 1 hour under nitrogen atmosphere to obtain product A, then add gallic acid, Product A is mixed with silver nitrate solution at a molar ratio of 0.5:0.1:1, and then added dropwise to NaBH with a concentration of 6 times that of silver nitrate solution after the ice-water bath. 4 In the solution, stir quickly, and age after the dropwise addition, to obtain.

[0041]Soak the collagen substrate prepared in Example 1 into the nano silver aqueous solution, the concentration of nano silver is 100ug / mL. After soaking for 2 hours, the substrate was taken out, fully washed with deionized water to wash off the physically adsorbed nano-silver, and dried under vacuum conditions to form a second layer of nano-silver coating on the collagen substrate. Its SEM picture is as follows image 3 as shown in (a), image 3 (a) Granules of...

Embodiment 3

[0043] Soak the collagen substrate prepared in Example 2 into a mixed aqueous solution of EDC / NHS, wherein the molar ratio of EDC to NHS is 1:1.2, and the mass concentration of EDC is 1.5 mg / mL. After soaking and crosslinking for 8 hours, fully use Rinse with ion water and dry in vacuum to finally obtain a cross-linked chitosan / nano-silver composite antibacterial coating.

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Abstract

The invention provides a preparation method of a stability-enhanced compound antibacterial coating. The method comprises the following steps that (1) a chitosan water solution is used for soaking a collagen substrate; then, water washing is performed to remove uncombined chitosan, wherein the molecular weight of the chitosan is 50 thousand to 500 thousand; (2) a nano-silver water solution is usedfor soaking the matter obtained in the step (1); then, water washing is performed to remove uncombined nano-silver; (3) an EDC and NHS mixed solution is used for soaking the matter obtained in the step (2); then, water washing is performed; next, drying is performed to obtain the stability-enhanced compound antibacterial coating. The obtained compound antibacterial coating has three kinds of antibacterial functions of resisting the bacterial adhesion, releasing bactericides for sterilization and realizing contact sterilization; the antibacterial performance is excellent; meanwhile, the compound antibacterial coating also has excellent stability, is applicable to various kinds of complicated environment and is particularly applicable to medical instrument surface anti-bacterium.

Description

technical field [0001] The invention belongs to the field of antibacterial technology, and in particular relates to a composite antibacterial coating with enhanced stability, a preparation method and application thereof. Background technique [0002] Collagen-based medical devices are favored clinically due to their excellent biocompatibility and degradability. Collagen-based medical devices listed in China mainly include: collagen-based hemostatic sponges, wound dressings, collagen-based bone repair materials and collagen-based tissue engineering scaffolds. However, these medical devices often cause bacterial infections during clinical use, which are called biomaterial-related infections, which cause hundreds of thousands of deaths from such related infections worldwide every year, and have become a serious problem in the field of biomedicine . The adhesion and reproduction of bacteria on the surface of medical devices and the formation of biofilms with the extracellular ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/34A61L27/50A61L27/54
CPCA61L27/306A61L27/34A61L27/50A61L27/54A61L2300/104A61L2300/404A61L2300/606A61L2400/18A61L2420/02A61L2420/04C08L5/08
Inventor 刘公岩向俊余玲李开军夏琼芬
Owner SICHUAN UNIV
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