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Medical macromolecular three-dimensional structural composite material and preparation method thereof

A three-dimensional structure, composite material technology, applied in the field of nanocomposite materials and bionic modification, can solve the problems of affecting cell adhesion and growth, lack of cell recognition sites, insufficient hydrophilicity and cell affinity, etc., to achieve hydrophilicity. and improved biocompatibility, simple preparation process, and low equipment requirements

Inactive Publication Date: 2019-07-19
THE SECOND HOSPITAL AFFILIATED TO SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Poly(lactic-co-glycolic acid) (PLGA) has been widely used in medical biomaterials due to its excellent degradability. However, due to the lack of cell recognition sites on its surface, and insufficient hydrophilicity and cell affinity, etc. Disadvantage, which affects the adhesion and growth of cells on its surface

Method used

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preparation example Construction

[0026] The embodiment of the present invention discloses a preparation method of a degradable medical polymer three-dimensional structure composite material with antibacterial and osteogenic properties, including the following steps:

[0027] Step 1: Place 0.1-1 g of degradable medical polymer in 1-10 ml of organic solvent and stir for 2-12 hours; wherein, in this embodiment, the medical polymer mainly includes medical-grade aliphatic One or more combinations of polyester, polylactic acid, polycaprolactone, chitosan, cellulose, polyvinyl alcohol, etc. The organic solvent is one or more combinations of trifluoroethanol, acetone, hexafluoroisopropanol, dimethylformamide or tetrahydrofuran;

[0028] Step 2: preparing the mixed solution into a film with a three-dimensional structure; the method for preparing the three-dimensional structure mainly includes 3D printing, electrospinning, etc.;

[0029] Step 3: placing the three-dimensional structure material in a dopamine solution t...

specific example 1

[0034] Weigh 1 g of polycaprolactone and 1 g of chitosan, add them into 6 ml of hexafluoroisopropanol solvent, and stir evenly on a magnetic stirrer to prepare a polymer solution. After mixing evenly and electrospinning, the electrospinning conditions are: the voltage is 20kv, the distance is 30cm, and the flow rate is 0.5ml / h. Put the electrospun membrane into a vacuum drying oven to remove the solvent and dry it.

[0035] Prepare a Tris-HCl solution, adjust the pH value to 8.0, weigh 400mg of dopamine and add it to 10ml of Tris-HCl solution to prepare a dopamine solution with a concentration of 40mg / ml, soak the electrospun membrane in the solution, and pass oxygen for 1h , take the material out and rinse it with distilled water for 2 to 3 times, and dry it in a vacuum oven.

[0036] Prepare a blend solution of DMAPS zwitterionic polymer and collagen type II at a ratio of 30% and 70%, soak the electrospun membrane coated with dopamine in the solution, react for 12 hours, ta...

specific example 2

[0039] Use AutoCAD 2013 software to design 3D printed scaffolds, send 2gPCL into the 3D printer, PCL is stretched and melted and extruded filaments through the printing tip, and processed into up to three individual lengths with a diameter of 0.2mm and a gap of 1.0mm Silk, layer thickness 0.2 mm.

[0040] Prepare a Tris-HCl solution, adjust the pH value to 8.5, weigh 100mg of dopamine and add it to 10ml of Tris-HCl solution to prepare a dopamine solution with a concentration of 10mg / ml, soak the electrospun membrane in the solution, and pass oxygen for 5 hours , take the material out and rinse it with distilled water for 2 to 3 times, and dry it in a vacuum oven.

[0041] Prepare a blend solution of PSBMA zwitterionic polymer and collagen type II at a ratio of 50% and 50%, soak the electrospun membrane coated with dopamine in the solution, react for 24 hours, take out the material, and rinse with distilled water 2 to 3 times, dry and save.

[0042] The prepared thin film of ...

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Abstract

The invention provides a medical macromolecular three-dimensional structural composite material and a preparation method thereof. The method comprises the following steps that a degradable medical macromolecular polymer with the weight ratio of 1-10% is placed in an organic solvent and stirred for 2-12 hours; a mixed solution is prepared into a thin film with a three-dimensional structure; the three-dimensional structural material is placed in a dopamine solution for surface functionalization treatment; the three-dimensional structural material is taken out and placed in a zwitterionic polymerand collagen blended solution for a reaction of 12-48 hours; the three-dimensional structural material is taken out, washed with distilled water twice, dried under vacuum overnight and stored for use. The method is simple, feasible and high in controllability; the prepared composite material can resist bacterial adhesion, has good adhesion to cells and good biocompatibility, stability and mechanical properties, and is suitable for surface modification of three-dimensional stent materials.

Description

technical field [0001] The invention relates to the technical fields of nanocomposite materials and bionic modification, and in particular to a method for improving the adhesion of osteoblasts and having good antibacterial properties for degradable medical polymer three-dimensional materials. Background technique [0002] Biomedical polymer materials have their unique efficacy and characteristics in medicine, and have become one of the most extensive fields of research and application of biomaterials. Medical composite materials are biological materials composed of two or more materials, and most of the tissues of the human body can be considered as composite materials. Using bionics research methods, composite materials are used to simulate the organization, structure and function of the human body. It opens up broad prospects for the development of biomedical materials. [0003] Dental implant technology has been widely used in the restoration of dentition defect and loss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M15/37D06M15/00D06M15/15D06M101/32D06M101/02D06M101/30D06M101/06D06M101/24
CPCD06M15/00D06M15/15D06M15/37D06M2101/02D06M2101/06D06M2101/24D06M2101/30D06M2101/32
Inventor 钱蕴珠邢曈杨建新
Owner THE SECOND HOSPITAL AFFILIATED TO SUZHOU UNIV
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