Enzyme-responsive intelligent bacterial adhesion resistant and bactericidal layer-by-layer self-assembled multi-layer film coating and preparation method thereof
A layer-by-layer self-assembly, anti-bacterial adhesion technology, applied in coatings, pharmaceutical formulations, medical science, etc., can solve the problems of no anti-bacterial adhesion, poor biocompatibility, no sterilization, etc., to improve anti-bacteria The ability of bacteria to adhere, reduce frictional resistance, and improve the effect of bactericidal ability
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Embodiment 1
[0025] Add 100ml of deionized water or super ionized water (pH=7.0) to a 250ml small beaker, magnetically stir, slowly add 0.1g of hyaluronic acid, the concentration is 1mg / ml, while stirring, slowly add hydrochloric acid solution to adjust the pH to 2.9 and continue Stir until it dissolves, and also adjust the chitosan solution with pH=2.9 and polylysine with pH=9.5, which is the coating liquid, and at the same time adjust the corresponding washing liquid with the same pH. The silicone gel sheet is cut into 1.5×2.5cm by a blade 2 Size, used as a substrate, ultrasonic cleaning with water, N 2 Blow dry. Clamp the silicone gel sheet with tweezers and immerse it in 5mg / ml PEI solution for 2h for pretreatment. Take out the pretreated silicone gel and soak it back and forth in HA and CHI 10 times for 8 minutes each time. After taking it out, soak it in lotion for 1 ~2s, blow dry with N2, then soak it back and forth in HA and PLL solution 10 times, take it out, use N 2 Blow dry and p...
Embodiment 2
[0028] Add 100ml of deionized water (pH=7.0) to a 250ml small beaker, magnetically stir, slowly add 0.1g of hyaluronic acid to a concentration of 1mg / ml, while stirring, slowly add hydrochloric acid solution to adjust the pH to 2.9 and continue stirring Until it is dissolved, the chitosan solution with pH=2.9 and the polylysine with pH=9.5 are also adjusted, which is the coating liquid, and the corresponding washing liquid with the same pH is adjusted. The glass slide is used as the substrate. The glass slide is clamped with tweezers and immersed in a 5mg / ml PEI solution for 2h for pretreatment. The pretreated glass slides are immersed in HA and CHI for 10 times, each time for 8 minutes. Soak the lotion for 1~2s, dry it with N2, then soak it back and forth in HA and PLL solution 10 times, take it out, and use N 2 Blow dry and place on a glass plate. Dry at room temperature for 24h.
[0029] The static contact angle test film layer showed a certain degree of hydrophobicity, which...
Embodiment 3
[0031] Add 100ml of super-ionized water (pH=7.0) to a 250ml small beaker, magnetically stir, slowly add 0.1g of hyaluronic acid with a concentration of 1mg / ml, while stirring, slowly add hydrochloric acid solution to adjust the pH to 2.9 and continue stirring until it is dissolved. Also adjust the chitosan solution with pH=2.9 and polylysine with pH=9.5, which is the coating liquid. Glass is used as the substrate. The coating method adopts the spin coating method, first spin coating at 1000rad / min for 10s, then spin coating at 2500rad / min for 2min, repeat the operation, and spin coating 5 times. Finally, it was dried at room temperature for 24 hours. The thickness of the film tested by the cross-sectional field emission scanning electron microscope is 0.85±0.18μm. The static contact angle test film showed a certain degree of hydrophobicity, which was 95°±1.32°. Atomic force microscope observation revealed that the surface had very low roughness, and the RMS was 2.44±0.26 nm. ...
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