Method for constructing antifouling-sterilizing-releasing type surface coating by utilizing dopamine and product thereof

A technology of surface coating and dopamine, which is applied in the field of polymer coating preparation, can solve the problems of complex preparation methods of polymer brushes and single application substrate, achieve long-term anti-bacterial adhesion and kill bacteria, realize functional regeneration, Avoid complex effects with compositing methods

Active Publication Date: 2019-11-22
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In line with the above research trend, the invention patent application with publication number CN109232834A discloses an antibacterial polymer brush with tri

Method used

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  • Method for constructing antifouling-sterilizing-releasing type surface coating by utilizing dopamine and product thereof
  • Method for constructing antifouling-sterilizing-releasing type surface coating by utilizing dopamine and product thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Take a 50ml round bottom beaker, and add 0.57g of 3-(dimethyl(4-vinylbenzyl)amino)propanesulfonate (DVBAPS) and 0.07g of glycidyl methacrylate (GMA) to it in sequence With the mixed solvent (V:V=1:1) of 2.5ml trifluoroethanol and deionized water, stir 10 minutes and mix homogeneously, then add 0.004g initiator AIBN and stir for 15 minutes, then carry out nitrogen blowing for 15 minutes, then Place it in a water bath at 60°C for 6 hours. After the reaction is over, open the reaction flask and place it in an ice-water bath, then pour the reaction product into an ethanol solution, centrifuge and purify the precipitated polymer, and finally dry it in a vacuum oven to obtain Transparent polymer poly(GMA-co-DVBAPS).

[0033] (2) Weigh 0.06g dopamine hydrochloride and add 30ml Tris-HCl buffer solution, then add 0.18g poly(GMA-co-DVBAPS), 0.12g polylysine and 0.12g poly N-(2-hydroxyethyl) Acrylamide (pHEAA) was finally placed on a glass slide and co-deposited at room tempe...

Embodiment 2

[0035] (1) Take a 50ml round bottom beaker, add 0.314g of dimethylaminoethyl methacrylate (DMAEM), 0.07g of glycidyl methacrylate (GMA) and a mixture of 2.5ml of trifluoroethanol and deionized water to it Solvent (V:V=1:1), stirred for 10 minutes and mixed evenly, then added 0.004g initiator AIBN and stirred for 15 minutes, then carried out nitrogen blowing for 15 minutes, then placed in a water bath at 60°C for 6 hours, and waited After the reaction, the reaction flask was opened and placed in an ice-water bath, then the reaction product was poured into an ethanol solution, the precipitated polymer was purified by centrifugation, and finally dried in a vacuum oven to obtain a transparent polymer poly(GMA-co-DMAEMA).

[0036] (2) Weigh 0.06g dopamine hydrochloride and add 30ml Tris-HCl buffer solution, then add 0.18g poly(GMA-co-DMAEMA), 0.12g polylysine and 0.12g poly N-(2-hydroxyethyl) Acrylamide (pHEAA) was finally placed on a glass slide and co-deposited at room temperatur...

Embodiment 3

[0038](1) Take a 50ml round bottom beaker, add N-isopropylacrylamide (NIPAM) monomer 0.23g, glycidyl methacrylate (GMA) 0.07g and 2.5ml of trifluoroethanol and deionized water to it successively Mix the solvent (V:V=1:1), stir for 10 minutes and mix evenly, then add 0.004g initiator AIBN and stir for 15 minutes, then carry out nitrogen blowing for 15 minutes, and then place it in a water bath at 60°C for 6 hours. After the reaction is over, open the reaction flask and place it in an ice-water bath, then pour the reaction product into an ethanol solution, centrifuge and purify the precipitated polymer, and finally dry it in a vacuum oven to obtain a transparent polymer poly(GMA-co-NIPAM) .

[0039] (2) Weigh 0.06g of dopamine hydrochloride and add 30ml of Tris-HCl buffer solution, then add 0.18g of poly(GMA-co-NIPAM), 0.12g of polylysine and 0.12g of poly-N-(2-hydroxyethyl) Acrylamide (pHEAA) was finally placed on a glass slide and co-deposited at room temperature for 48 hours...

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Abstract

The invention discloses a method for constructing an antifouling-sterilizing-releasing type surface coating by using dopamine, which comprises the following steps: adding an epoxy group-containing stimuli-responsive polymer, a sterilization polymer and an anti-pollution polymer into a dopamine solution, and standing and co-depositing on a substrate to obtain the anti-pollution-sterilization-release surface coating. The method is simpler and more efficient and can be applied to any substrate, and the application range of antibacterial surfaces is greatly expanded. The invention further discloses the antifouling-sterilizing-releasing type surface coating prepared by the method, the coating can resist bacterial adhesion for a long time and kill bacteria, and when the adhesion amount of dead bacteria reaches a certain degree, the bacteria adhered to the surface can be released by changing external conditions, and functional regeneration is realized.

Description

technical field [0001] The invention relates to the field of preparation of polymer coatings, in particular to a method for using dopamine to construct a surface coating with triple functions of "anti-pollution-sterilization-release" and its products. Background technique [0002] With the wide application of medical implant materials, the problem of infection is becoming more and more serious. The reason is that the surface of the material provides conditions for the colonization of bacteria, and once the bacteria colonize and form bacterial biofilms, it will be difficult deal with. In order to prevent bacteria from adhering and kill the adhering bacteria, many antibacterial materials and antibacterial coatings have been continuously explored and studied. The antibacterial coating has the advantages of simple preparation method and strong structure controllability, and has shown broad application prospects in the fields of surface and interface modification, nano-hybrid ma...

Claims

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Application Information

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IPC IPC(8): C09D125/18C09D133/14C09D133/24C09D177/04C09D5/16
CPCC08L2205/025C08L2205/03C09D5/1668C09D5/1687C09D125/18C09D133/14C09D133/24C08L77/04C08L33/24C08K5/17
Inventor 杨晋涛毛世华王晓宇钟明强陈枫范萍
Owner ZHEJIANG UNIV OF TECH
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