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Engineered surfaces for reducing bacterial adhesion

An engineered, bacterial technology used in nanotechnology, cleaning methods and utensils, chemical instruments and methods for materials and surface science to solve problems such as increasing surface complexity, disrupting microbial adhesion, and clogging devices, Achieve improved method efficiency, high thermal uniformity, and reduced shrinkage

Inactive Publication Date: 2013-06-26
3M INNOVATIVE PROPERTIES CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

5) Sustained crystal formation and biofilm growth in alkaline urine lead to severe fouling and eventual blockage of the device requiring recannulation of the patient
This attempt raises the need for increased surface complexity to sufficiently disrupt microbial adhesion, suggesting that simpler patterns are insufficient
Although effective in reducing microbial adhesion in some cases, these surfaces can be expensive to replicate on a sufficient scale

Method used

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  • Engineered surfaces for reducing bacterial adhesion
  • Engineered surfaces for reducing bacterial adhesion
  • Engineered surfaces for reducing bacterial adhesion

Examples

Experimental program
Comparison scheme
Effect test

preparation example A

[0110] Generate first-level engineered surface (microstructure)

[0111] In order to manufacture a mother board for microstructures, a photoresist (PR) pattern is manufactured on a silicon wafer by optical lithography. Using the parameters listed in Table 1, a 1500nm-thick silicon dioxide layer was coated by plasma enhanced chemical vapor deposition (PECVD) using Model PlasmaLab System 100 available from Oxford Instruments, Yatton, UK PR microstructure. Use fast deposition rates to produce surface roughness.

[0112] Table 1. Used to deposit SiO 2 Layer condition

[0113] Reactants / conditions

Value

SiH 4

300sccm*

N 2 O

1600sccm

n2

600sccm

Stress

1600mTorr(=213Pa)

Temperature

60℃

High frequency (HF) power

ll0W

[0114] *Standard cubic centimeter

[0115] Then use double-sided tape to adhere the mother board prepared as above to the stainless steel pan. It is then made conductive by electroplating a thin layer of silver. Then at a temperature of 54.4°C (130...

preparation example B

[0124] Generate second-level engineered features on the first-level structure (nanostructure / nanostructure on microstructure) Feature structure)

[0125] Fabrication of nano-featured structures on the surface of parallel triangular rail array

[0126] The second-level topography (nanostructures or nanofeatures) is produced on the substrate (first-level) microstructure, which is first generated by the method described in Preparation Example A above. The base PDMS structure is Comparative Example 3, which is a PDMS surface formed into an array of parallel triangular rungs, wherein the peaks of the rungs have a spacing of 11 μm. PDMS replica first use O 2 Plasma (O 2 Flow: 40sccm, RF power: 75W, P: 65mTorr, time: 15s) processing. This step is followed by immersion of indium tin oxide (ITO) nanoparticles (ITONP, available from Advanced Nano Products Co., Ltd, Chungcheonbuk-do, Chungcheonbuk-do, Korea) at a coating speed of 65mm / min. ,Korea)) suspension in isopropanol (IPA) in a vo...

example 5

[0133] Example 5 was prepared by the same method as Example 4 above, except that the base PDMS structure was an array of parallel triangular rungs with a pitch of 6 μm between rung peaks. Example 5 is shown in Figure 11c-11d in.

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Abstract

Disclosed are surfaces for resisting and reducing biofilm formation, particularly on medical articles (100). The surfaces include a plurality of microstructures (120) including a plurality of nanofeatures (140) arranged according to at least one unit cell. Also disclosed are methods for creating anti - adherent surfaces.

Description

Background technique [0001] Biofilm is a structured population of microorganisms encased in an extracellular polymer matrix, which usually adheres firmly to the surface of biological materials and host tissues. Bacterial biofilms are a significant problem in the development of materials for several different applications that are exposed to aqueous body fluids for a long time: medical devices, filtration systems for food processing and other industrial applications, marine structures, and others Coating for antifouling applications. When compared to free "pathogens", bacteria living in biofilms are significantly more resistant to host defenses and antibiotic and antimicrobial treatments, thereby increasing the use of in-dwelling and other tissue contact devices Possibility of infection. [0002] It is believed that biofilms have a significant role in catheter-related urinary tract infections (CAUTI), catheter-related bloodstream infections, and ventilator-associated pneumonia (V...

Claims

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Application Information

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IPC IPC(8): B08B17/06B82Y30/00
CPCB08B17/065Y10T428/24355B08B17/06A61F13/00063
Inventor G·马尔科·博马里托马修·T·肖尔茨迈克尔·J·斯瓦罗夫斯基杰里米·M·亚伍德斯科特·M·施诺布里希罗伯特·J·德沃张俊颖特里·L·史密斯
Owner 3M INNOVATIVE PROPERTIES CO
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